Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa

	Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa
	Shen, ZQ ; Chen, ZH ; Li, L; Lei, WY ; Hao, XJ
	2000-04-01
发表期刊	PLANTA MEDICA
卷号	66 期号:3 页码:287-289
摘要	Spiramine Q, a diterpene, was isolated from a Chinese herbal plant Spiraea japonica var. incisa Yu. Born's and Wan HY's methods were used to investigate effects of spiramine Q on rabbit platelet aggregation and serotonin release, respectively. Its antithrombotic effect in mice was also evaluated by Myers' method. Spiramine Q selectively inhibited arachidonic acid-induced platelet aggregation in vitro or ex vivo, and decreased serotonin secretion from rabbit platelets. Spiramine Q (5 mg/kg) decreased the mouse mortality caused by injection of 80 mg/kg arachidonic acid in the tail vein. The results suggested that spiramine Q showed potent antiplatelet and antithrombotic activites.
收录类别	SCI
语种	英语
WOS记录号	WOS:000086893900021
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23964
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Kunming Med Coll, Yunnan Pharmaceut Labs Nat Prod, Kunming 650031, Yunnan Province, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Shen, ZQ,Chen, ZH,Li, L,et al. Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa[J]. PLANTA MEDICA,2000,66(3):287-289.
APA	Shen, ZQ,Chen, ZH,Li, L,Lei, WY,&Hao, XJ.(2000).Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa.PLANTA MEDICA,66(3),287-289.
MLA	Shen, ZQ,et al."Antiplatelet and antithrombotic effects of the diterpene spiramine Q from Spiraea japonica var. incisa".PLANTA MEDICA 66.3(2000):287-289.

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