Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae
Zhu, Kevin Y.1,2; Fu, Q.1,2; Xie, Heidi Q.1,2; Xu, Sherry L.1,2; Cheung, Anna W. H.1,2; Zheng, Ken Y. Z.1,2; Luk, Wilson K. W.1,2; Choi, Roy C. Y.1,2; Lau, David T. W.1,2; Dong, Tina T. X.1,2; Jiang, Zhi Y.3; Chen, Ji J.3; Tsim, Karl W. K.1,2
2010-12-01
Source PublicationJOURNAL OF SEPARATION SCIENCE
Volume33Issue:23-24Pages:3666-3674
AbstractKaixinsan is an ancient Chinese herbal decoction mainly prescribed for patients suffering from mental depression. This decoction was created by Sun Si-miao of Tang Dynasty (A.D. 600) in ancient China, and was composed of four herbs: Radix and Rhizome Ginseng, Radix Polygalae, Rhizoma Acori Tatarinowii and Poria. Historically, this decoction has three different formulations, each recorded at a different point in time. In this study, the chemical compositions of all three Kaixinsan formulae were analyzed. By using rapid resolution LC coupled with a diode-array detector and an ESI triple quadrupole tandem MS (QQQ-MS/MS), the Radix and Rhizome Ginseng-derived ginsenosides including Rb(1), Rd, Re, Rg(1), the Radix Polygalae-derived 3,6'-disinapoyl sucrose, the Rhizoma Acori Tatarinowii-derived alpha-and beta-asarone and the Poria-derived pachymic acid were compared among the three different formulations. The results showed variations in the solubility of different chemicals between one formula and the others. This systematic method developed could be used for the quality assessment of this herbal decoction.
KeywordChemical Assessment Depression Herbal Mixture Lc-ms Tcm
DOI10.1002/jssc.201000498
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000285312700007
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/23929
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, Hong Kong, Hong Kong, Peoples R China
2.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
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GB/T 7714
Zhu, Kevin Y.,Fu, Q.,Xie, Heidi Q.,et al. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae[J]. JOURNAL OF SEPARATION SCIENCE,2010,33(23-24):3666-3674.
APA Zhu, Kevin Y..,Fu, Q..,Xie, Heidi Q..,Xu, Sherry L..,Cheung, Anna W. H..,...&Tsim, Karl W. K..(2010).Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae.JOURNAL OF SEPARATION SCIENCE,33(23-24),3666-3674.
MLA Zhu, Kevin Y.,et al."Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae".JOURNAL OF SEPARATION SCIENCE 33.23-24(2010):3666-3674.
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