Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae

doi:10.1002/jssc.201000498

	Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae
	Zhu, Kevin Y.1,2; Fu, Q.1,2; Xie, Heidi Q.1,2; Xu, Sherry L.1,2; Cheung, Anna W. H.1,2; Zheng, Ken Y. Z.1,2; Luk, Wilson K. W.1,2; Choi, Roy C. Y.1,2; Lau, David T. W.1,2; Dong, Tina T. X.1,2; Jiang, Zhi Y.3; Chen, Ji J.3; Tsim, Karl W. K.1,2
	2010-12-01
发表期刊	JOURNAL OF SEPARATION SCIENCE
卷号	33 期号:23-24 页码:3666-3674
摘要	Kaixinsan is an ancient Chinese herbal decoction mainly prescribed for patients suffering from mental depression. This decoction was created by Sun Si-miao of Tang Dynasty (A.D. 600) in ancient China, and was composed of four herbs: Radix and Rhizome Ginseng, Radix Polygalae, Rhizoma Acori Tatarinowii and Poria. Historically, this decoction has three different formulations, each recorded at a different point in time. In this study, the chemical compositions of all three Kaixinsan formulae were analyzed. By using rapid resolution LC coupled with a diode-array detector and an ESI triple quadrupole tandem MS (QQQ-MS/MS), the Radix and Rhizome Ginseng-derived ginsenosides including Rb(1), Rd, Re, Rg(1), the Radix Polygalae-derived 3,6'-disinapoyl sucrose, the Rhizoma Acori Tatarinowii-derived alpha-and beta-asarone and the Poria-derived pachymic acid were compared among the three different formulations. The results showed variations in the solubility of different chemicals between one formula and the others. This systematic method developed could be used for the quality assessment of this herbal decoction.
关键词	Chemical Assessment Depression Herbal Mixture Lc-ms Tcm
DOI	10.1002/jssc.201000498
收录类别	SCI
语种	英语
WOS记录号	WOS:000285312700007
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23929
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Hong Kong Univ Sci & Technol, Div Life Sci, Sect Marine Ecol & Biotechnol, Hong Kong, Hong Kong, Peoples R China 2.Hong Kong Univ Sci & Technol, Ctr Chinese Med, Hong Kong, Hong Kong, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Kevin Y.,Fu, Q.,Xie, Heidi Q.,et al. Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae[J]. JOURNAL OF SEPARATION SCIENCE,2010,33(23-24):3666-3674.
APA	Zhu, Kevin Y..,Fu, Q..,Xie, Heidi Q..,Xu, Sherry L..,Cheung, Anna W. H..,...&Tsim, Karl W. K..(2010).Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae.JOURNAL OF SEPARATION SCIENCE,33(23-24),3666-3674.
MLA	Zhu, Kevin Y.,et al."Quality assessment of a formulated Chinese herbal decoction, Kaixinsan, by using rapid resolution liquid chromatography coupled with mass spectrometry: A chemical evaluation of different historical formulae".JOURNAL OF SEPARATION SCIENCE 33.23-24(2010):3666-3674.

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