| Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans | |
Duan, Lin1; Tao, Hong-Wen1; Hao, Xiao-Jiang2 ; Gu, Qian-Qun1; Zhu, Wei-Ming1
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| 2009-09-01 | |
| 发表期刊 | PLANTA MEDICA
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| 卷号 | 75期号:11页码:1241-1245 |
| 摘要 | Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3'-methoxy-8- methyl-1'-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Delta 8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7'R,8'S)-4,5'-diliydroxy-3,3'-dimethoxy-7,7'-epoxylignan (4) showed the corresponding activities with IC(50) values of 39.4 and 2.11 mu M, respectively. |
| 关键词 | Myristica Fragrans Myristicaceae Cytotoxicity Antioxidative Activity Phenylpropanoids |
| DOI | 10.1055/s-0029-1185506 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000270401600012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/23889 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,et al. Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans[J]. PLANTA MEDICA,2009,75(11):1241-1245. |
| APA | Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,Gu, Qian-Qun,&Zhu, Wei-Ming.(2009).Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans.PLANTA MEDICA,75(11),1241-1245. |
| MLA | Duan, Lin,et al."Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans".PLANTA MEDICA 75.11(2009):1241-1245. |
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| s-0029-1185506.pdf（134KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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