Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans
Duan, Lin1; Tao, Hong-Wen1; Hao, Xiao-Jiang2; Gu, Qian-Qun1; Zhu, Wei-Ming1
2009-09-01
发表期刊PLANTA MEDICA
卷号75期号:11页码:1241-1245
摘要Two new phenolic compounds were isolated from the fruits of Myristica fragrans and their structures were elucidated as (-)-1-(2,6-dihydroxyphenyl)-9-[4-hydroxy-3-(p-menth-1-en-8-oxy)phenyl]-1-nonanone (1) and (7R,8R)-7,8-dihydro-7-(3,4-dihydroxyphenyl)-3'-methoxy-8- methyl-1'-(E-propenyl)benzofuran (2). In addition, the absolute configuration of (+)-Delta 8'-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan (3) was determined for the first time through spectroscopic and chemical methods. Their antioxidative activities against 2,2-diphenyl-1-picrylhydrazyl radical and cytotoxicity against K-562 cells were tested, and (7S,8S,7'R,8'S)-4,5'-diliydroxy-3,3'-dimethoxy-7,7'-epoxylignan (4) showed the corresponding activities with IC(50) values of 39.4 and 2.11 mu M, respectively.
关键词Myristica Fragrans Myristicaceae Cytotoxicity Antioxidative Activity Phenylpropanoids
DOI10.1055/s-0029-1185506
收录类别SCI
语种英语
WOS记录号WOS:000270401600012
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/23889
专题植物化学与西部植物资源持续利用国家重点实验室
作者单位1.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources, Kunming, Peoples R China
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Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,et al. Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans[J]. PLANTA MEDICA,2009,75(11):1241-1245.
APA Duan, Lin,Tao, Hong-Wen,Hao, Xiao-Jiang,Gu, Qian-Qun,&Zhu, Wei-Ming.(2009).Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans.PLANTA MEDICA,75(11),1241-1245.
MLA Duan, Lin,et al."Cytotoxic and Antioxidative Phenolic Compounds from the Traditional Chinese Medicinal Plant, Myristica fragrans".PLANTA MEDICA 75.11(2009):1241-1245.
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