Effects of three diterpenoids on tumour cell proliferation and telomerase activity
Yang, Yunshan1; Sun, Handong2; Zhou, Yiping1; Ji, Shuyu1; Li, Malin1
2009
Source PublicationNATURAL PRODUCT RESEARCH
Volume23Issue:11Pages:1007-1012
AbstractXerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10-4-10-8 mol L-1, three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs.
KeywordXb Mb Eb Cell Proliferation Telomerase Activity
DOI10.1080/14786410802295149
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Applied ; Chemistry, Medicinal
WOS IDWOS:000266918100005
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/23882
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yunshan,Sun, Handong,Zhou, Yiping,et al. Effects of three diterpenoids on tumour cell proliferation and telomerase activity[J]. NATURAL PRODUCT RESEARCH,2009,23(11):1007-1012.
APA Yang, Yunshan,Sun, Handong,Zhou, Yiping,Ji, Shuyu,&Li, Malin.(2009).Effects of three diterpenoids on tumour cell proliferation and telomerase activity.NATURAL PRODUCT RESEARCH,23(11),1007-1012.
MLA Yang, Yunshan,et al."Effects of three diterpenoids on tumour cell proliferation and telomerase activity".NATURAL PRODUCT RESEARCH 23.11(2009):1007-1012.
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