| Effects of three diterpenoids on tumour cell proliferation and telomerase activity | |
Yang, Yunshan1 ; Sun, Handong2; Zhou, Yiping1; Ji, Shuyu1; Li, Malin1
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| 2009 | |
| 发表期刊 | NATURAL PRODUCT RESEARCH
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| 卷号 | 23期号:11页码:1007-1012 |
| 摘要 | Xerophilusin B (XB), macrocalin B (MB) and eriocalyxin B (EB) belong to ent-kaurene diterpenoids. The inhibition effects of three ent-kaurane compounds on the proliferation of six tumour lines (K562, HL-60, A549, MKN, HCT and CA) were estimated by methyl-thiazol-tetrazolium, and the telomerase activity in K562 cells was measured by the telomeric repeat amplification protocol-enzyme-linked immunosorbent assay. We found that XB, MB and EB could significantly inhibit the proliferation of tumour cells. Within the concentration range of 10-4-10-8 mol L-1, three ent-kaurane compounds could markedly inhibit the telomerase activity in K562 cells, and their effects on telomerase were exhibited in a dose-dependent manner. Our results demonstrate that XB, MB and EB can inhibit the proliferation of tumour cells and the telomerase activity, which provides data for developing ent-compounds as antitumour drugs. |
| 关键词 | Xb Mb Eb Cell Proliferation Telomerase Activity |
| DOI | 10.1080/14786410802295149 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000266918100005 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/23882 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Kunming Med Coll, Yunnan Pharmacol Lab Nat Prod, Kunming, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Yunshan,Sun, Handong,Zhou, Yiping,et al. Effects of three diterpenoids on tumour cell proliferation and telomerase activity[J]. NATURAL PRODUCT RESEARCH,2009,23(11):1007-1012. |
| APA | Yang, Yunshan,Sun, Handong,Zhou, Yiping,Ji, Shuyu,&Li, Malin.(2009).Effects of three diterpenoids on tumour cell proliferation and telomerase activity.NATURAL PRODUCT RESEARCH,23(11),1007-1012. |
| MLA | Yang, Yunshan,et al."Effects of three diterpenoids on tumour cell proliferation and telomerase activity".NATURAL PRODUCT RESEARCH 23.11(2009):1007-1012. |
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