| Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus | |
Zhang, Ji-Xia1; He, Zhi-An1; Chen, Zheng-Yue1; Wang, Yong-Xue1; Bai, Su-Ping1; Sun, Han-Dong2
| |
| 2009 | |
| 发表期刊 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
 |
| 卷号 | 11期号:8页码:693-697 |
| 摘要 | Two new ent-kaurane diterpenoids, dayecrystals D-E (1-2), together with nine known compounds, isojaponin A (3), rabdosin A (4), lushanrubescensin J (5), wikstroemioidin B (6), maoyecrystal C (7), rabdosin B (8), isodonal (9), shikokianin (10), and effusanin A (11), were isolated from the leaves of Isodon macrophyllus. The structures of the new compounds were elucidated using 1D and 2D NMR spectroscopy. The (13)C-NMR spectral data of compound 4 are reported for the first time. All of the compounds were tested for their cytotoxicities against DU145 and LoVo human tumor cells. Compounds 4, 10, and 11 showed inhibitory effects on DU145 cells with IC(50) values 5.90, 4.24, and 3.16 mu M, and LoVo cells with IC(50) values 14.20, 17.55, and 3.02 mu M, respectively. |
| 关键词 | Isodon Macrophyllus Ent-kauranoids Diterpene Dayecrystals D-e Cytotoxicity |
| DOI | 10.1080/10286020802361271 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268666300002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/23878 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Xinxiang Med Univ, Pharmaceut Lab, Xinxiang, Henan Province, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ji-Xia,He, Zhi-An,Chen, Zheng-Yue,et al. Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2009,11(8):693-697. |
| APA | Zhang, Ji-Xia,He, Zhi-An,Chen, Zheng-Yue,Wang, Yong-Xue,Bai, Su-Ping,&Sun, Han-Dong.(2009).Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,11(8),693-697. |
| MLA | Zhang, Ji-Xia,et al."Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 11.8(2009):693-697. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| 10286020802361271.pd（257KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论