Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells

doi:10.1158/1535-7163.MCT-07-0073

	Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells
	Efferth, Thomas 1; Kah, Stefan 2,3,6; Paulus, Kerstin 4; Adams, Michael 2; Rauh, Rolf 5; Boechzelt, Herbert 3; Hao, Xiaojiang6 ; Kaina, Bernd 5; Bauer, Rudolf 2
	2008
发表期刊	MOLECULAR CANCER THERAPEUTICS
卷号	7 期号:1 页码:152-161
摘要	The cure from cancer is still not a reality for all patients, which is mainly due to the limitations of chemotherapy (e.g., drug resistance and toxicity). Apart from the high-throughput screening of synthetic chemical libraries, natural products represent attractive alternatives for drug development. We have done a systematic bioactivity-based screening of natural products derived from medicinal plants used in traditional Chinese medicine. Plant extracts with growth-inhibitory activity against tumor cells have been fractionated by chromatographic techniques. We have isolated the bioactive compounds and elucidated the chemical structures by nuclear magnetic resonance and mass spectrometry. By this strategy, we identified 25-O-acetyl-23,24-dihydro-cucurbitacin F as a cytotoxic constituent of Quisqualis indica. Another promising compound identified by this approach was miltirone from Salvia miltiorrhiza. The IC50 values for miltirone of 60 National Cancer Institute cell lines were associated with the micro-array-based expression of 9,706 genes. By COMPARE and hierarchical cluster analyses, candidate genes were identified, which significantly predicted sensitivity or resistance of cell lines to miltirone.
DOI	10.1158/1535-7163.MCT-07-0073
收录类别	SCI
语种	英语
WOS记录号	WOS:000252580900016
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/23874
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.German Canc Res Ctr, D-69120 Heidelberg, Germany 2.Graz Univ, Inst Pharmaceut Sci, A-8010 Graz, Austria 3.Joanneum Res, Graz, Austria 4.Univ Dusseldorf, Inst Pharmaceut Biol, Dusseldorf, Germany 5.Johannes Gutenberg Univ Mainz, Inst Toxicol, D-6500 Mainz, Germany 6.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming, Peoples R China
推荐引用方式 GB/T 7714	Efferth, Thomas,Kah, Stefan,Paulus, Kerstin,et al. Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells[J]. MOLECULAR CANCER THERAPEUTICS,2008,7(1):152-161.
APA	Efferth, Thomas.,Kah, Stefan.,Paulus, Kerstin.,Adams, Michael.,Rauh, Rolf.,...&Bauer, Rudolf.(2008).Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.MOLECULAR CANCER THERAPEUTICS,7(1),152-161.
MLA	Efferth, Thomas,et al."Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells".MOLECULAR CANCER THERAPEUTICS 7.1(2008):152-161.

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