Natural biflavones as novel inhibitors of cathepsin B and K

doi:10.1016/j.ejmech.2006.06.002

	Natural biflavones as novel inhibitors of cathepsin B and K
	Zeng, G. -Z.; Pan, X. -L.; Tan, N. -H.; Xiong, J.; Zhang, Y. M.
	2006-11-01
发表期刊	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN	0223-5234
卷号	41 期号:11 页码:1247-1252
摘要	Cathepsin B and K, two important members in lysosomal proteases, involve in many serious human diseases, such as tumor and osteoporosis. In order to find their novel inhibitors, we performed the inhibition assays of cathepsin B and cathepsin K in vitro, randomly screened compounds from plants, and found six biflavones, named AMF1-5 and HIF, can potently inhibit cathepsin B and cathepsin K, especially AMF4 and HIF with IC50 of 0.62 and 0.58 W against cathepsin B. They are novel inhibitors for cathepsin B and K. Inhibition and flexible docking studies indicated that these biflavones are reversible inhibitors of cathepsin B, and their binding patterns and interaction modes with cathepsin B made them more specific to cathepsin B endopeptidase. (c) 2006 Elsevier Masson SAS. All rights reserved.
关键词	Biflavones Inhibitors Cathepsin b Cathepsin k Docking
学科领域	Chemistry ; Medicinal
DOI	10.1016/j.ejmech.2006.06.002
收录类别	SCI
语种	英语
WOS记录号	WOS:000242454100003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/2149
专题	植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Zeng, G. -Z.,Pan, X. -L.,Tan, N. -H.,et al. Natural biflavones as novel inhibitors of cathepsin B and K[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2006,41(11):1247-1252.
APA	Zeng, G. -Z.,Pan, X. -L.,Tan, N. -H.,Xiong, J.,&Zhang, Y. M..(2006).Natural biflavones as novel inhibitors of cathepsin B and K.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,41(11),1247-1252.
MLA	Zeng, G. -Z.,et al."Natural biflavones as novel inhibitors of cathepsin B and K".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 41.11(2006):1247-1252.

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