Natural inhibitors targeting osteoclast-mediated bone resorption
Zeng, Guang-Zhi; Tan, Ning-Hua; Hao, Xiao-Jiang; Mu, Quan-Zhang; Li, Rong-Tao
2006-12-15
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume16Issue:24Pages:6178-6180
AbstractHuman cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3) integrin are the key regulators in osteoclast-mediated bone resorption. In this paper, we found natural inhibitors 1-10 for them by enzyme inhibition assays. Inhibitors 1-7, 8-9, and 10 are novel inhibitors of human cathepsin K, matrix metalloproteinase 9, and alpha(V)beta(3), respectively. (c) 2006 Elsevier Ltd. All rights reserved.
KeywordCathepsin k Matrix Metalloproteinase 9 Alpha v Beta(3) Natural Inhibitor Bone Resorption
Subject AreaChemistry ; Medicinal ; Chemistry ; Organic
DOI10.1016/j.bmcl.2006.09.042
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy ; Chemistry
WOS SubjectChemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000242674100006
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/2133
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China
2.Chinese Acad Sci, Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Zeng, Guang-Zhi,Tan, Ning-Hua,Hao, Xiao-Jiang,et al. Natural inhibitors targeting osteoclast-mediated bone resorption[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2006,16(24):6178-6180.
APA Zeng, Guang-Zhi,Tan, Ning-Hua,Hao, Xiao-Jiang,Mu, Quan-Zhang,&Li, Rong-Tao.(2006).Natural inhibitors targeting osteoclast-mediated bone resorption.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,16(24),6178-6180.
MLA Zeng, Guang-Zhi,et al."Natural inhibitors targeting osteoclast-mediated bone resorption".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16.24(2006):6178-6180.
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