Li,XL (reprint author),Chinese Acad Sci,Kunming Inst Bot,Inst Tibetan Plateau Res Kunming,Germplasm Bank Wild Species Southwest China,Key L,Kunming 650201,Peoples R China.
Two novel heterodimers, denticulatains A (1) and B (2), were isolated from the fronds of Macaranga denticulata. They possess an unprecedented stilbene-diterpene-type skeleton, which represents a unique class of prenylated stilbene. Their structures were elucidated by comprehensive analyses of extensive NMR and MS spectroscopic data. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase with the inhibition ratios of 22.1% and 27.5%, respectively, at a concentration of 50 mu M.
National Natural Science Foundation of China [31300293, 81422046]
; General Project of Applied Foundation Research, Yunnan Province [2013FB067]
; Ministry of Science and Technology of China [2012FY110300]
; Major State Basic Research Development Program [2010CB951704]
1.Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Germplasm Bank Wild Species Southwest China,Key L, Kunming 650201, Peoples R China 2.Shandong Acad Sci, Inst Biol, Jinan 250014, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China