Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines
Liu, Chin-Yu1; Cheng, Yung-Yi1; Chang, Ling-Chu1; Huang, Li-Jiau1; Chou, Li-Chen1,2; Huang, Chi-Hung2; Tsai, Meng-Tung1; Liao, Chih-Chang1; Hsu, Mei-Hua1; Lin, Hui-Yi1; Wu, Tian-Shung3; Wen, Yen-Fang4; Zhao, Yu5,6; Kuo, Sheng-Chu1,6; Lee, Kuo-Hsiung6,7; Kuo,SC (reprint author),China Med Univ,Grad Inst Pharmaceut Chem,91 Hsueh Shih Rd,Taichung 40402,Taiwan.; sckuo@mail.cmu.edu.tw; khlee@unc.edu
2015-01-27
发表期刊EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷号90页码:775-787
摘要To develop new anticancer drug candidates from 2-arylnaphthyridin-4-one (AN), we have designed and synthesized a series of 3'-hydroxy and 6-hydroxy derivatives of AN. The results of cytotoxicity screening indicated that the replacement of the 3'-methoxy moiety on the C-ring phenyl group of AN (6a-e) with 3'-hydroxy (7a-e) made no significant effect on the inhibitory activity against HL-60, Hep3B and NCI-H460 cancer cell lines. On the other hand, replacing the 6-methoxy group on the A-ring of AN (6g-i) with a 6-hydroxy group (7g-i) resulted in reduced inhibitory activity against the above three cancer cell lines. Among the above-mentioned target compounds, 2-(3-hydroxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (7a) demonstrated the greatest potency and the best selectivity toward tumorigenic cancer cell lines. In a 7a preliminary mechanism of action study in Hep3B hepatoma cells, 7a showed the effects on microtubules followed by cell cycle arrest and sequentially led to apoptosis.
关键词2-arylnaphthyridin-4-ones Antitumor Agents Phosphate Prodrug
资助信息National Science Council of the Republic of China [NSC101-2320-B-039-008]; National Cancer Institute, NIH [CA177584]
学科领域Chemistry, Medicinal
DOI10.1016/j.ejmech.2014.11.062
收录类别SCI ; IC
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Chemistry, Medicinal
WOS记录号WOS:000348951900061
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/20665
专题中国科学院东亚植物多样性与生物地理学重点实验室
通讯作者Kuo,SC (reprint author),China Med Univ,Grad Inst Pharmaceut Chem,91 Hsueh Shih Rd,Taichung 40402,Taiwan.; sckuo@mail.cmu.edu.tw; khlee@unc.edu
作者单位1.China Med Univ, Grad Inst Pharmaceut Chem, Taichung 40402, Taiwan
2.Hung Kuang Univ, Grad Sch Biotechnol, Taichung 43302, Taiwan
3.Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan
4.Ind Technol Res Inst, Hsinchu 31040, Taiwan
5.Chinese Acad Sci, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
6.Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA
7.China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan
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Liu, Chin-Yu,Cheng, Yung-Yi,Chang, Ling-Chu,et al. Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2015,90:775-787.
APA Liu, Chin-Yu.,Cheng, Yung-Yi.,Chang, Ling-Chu.,Huang, Li-Jiau.,Chou, Li-Chen.,...&khlee@unc.edu.(2015).Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,90,775-787.
MLA Liu, Chin-Yu,et al."Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 90(2015):775-787.
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