中国科学院昆明植物研究所机构知识库
Advanced  
KIB OpenIR  > 中国科学院东亚植物多样性与生物地理学重点实验室  > 期刊论文
题名: Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish
作者: Lee,Ik-Soo ; Kim,Young Sook ; Jung,Seung-Hyun ; Yu,Song Yi ; Kim,Joo-Hwan ; Sun,Hang ; Kim,Jin Sook
刊名: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
出版日期: 2015
卷号: 79, 期号:4, 页码:581-586
关键词: lignans ; Scrophulariaceae ; vascular endothelial growth factor ; zebrafish ; Brandisia hancei
学科分类: Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Chemistry, Applied; Food Science & Technology
DOI: 10.1080/09168451.2014.991687
通讯作者: Kim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Dev Grp,Taejon,South Korea. ; jskim@kiom.re.kr
文章类型: Article
英文摘要: In our continuing search for novel antiangiogenic agents, a new lignan glycoside, (7R,8R)-1-(4-O-beta-d-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (1), along with three known lignans (2-4), were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-4) were subjected to an in vitro bioassay to evaluate their effects on vascular endothelial growth factor (VEGF)-induced vascular permeability and migration of human retinal endothelial cells (HRECs). Of the compounds tested, compound 1 resulted in the greatest reduction in VEGF-induced vascular permeability by about 31.5% at 10 mu M compared to the VEGF-treated control. In the migration assay, compounds 1 and 2 significantly decreased VEGF-induced HREC migration. Furthermore, zebrafish embryos treated with compounds 1 and 2 showed mild reductions of dorsal longitudinal anastomotic vessel (DLAV) formation.
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; PHENYLETHANOIDS ; ANGIOGENESIS ; NEOLIGNANS ; ACTEOSIDE
收录类别: SCI
项目资助者: Korea Institute of Oriental Medicine [K14040]
语种: 英语
WOS记录号: WOS:000353479000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/20639
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Lee-2015-Lignans from the stems and leaves of.pdf(373KB)----开放获取View Download
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Lee,Ik-Soo]'s Articles
[Kim,Young Sook]'s Articles
[Jung,Seung-Hyun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Lee,Ik-Soo]‘s Articles
[Kim,Young Sook]‘s Articles
[Jung,Seung-Hyun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Lee-2015-Lignans from the stems and leaves of.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院昆明植物研究所 - Feedback
Powered by CSpace