Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish
Lee,Ik-Soo; Kim,Young Sook; Jung,Seung-Hyun; Yu,Song Yi; Kim,Joo-Hwan; Sun,Hang; Kim,Jin Sook; Kim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Dev Grp,Taejon,South Korea.; jskim@kiom.re.kr
2015
Source PublicationBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume79Issue:4Pages:581-586
Abstract

In our continuing search for novel antiangiogenic agents, a new lignan glycoside, (7R,8R)-1-(4-O-beta-d-glucopyranosyl-3-methoxyphenyl)-2-{2-methoxy-4-[1-(E)-propene-3-ol]-phenoxyl}-propane-1,3-diol (1), along with three known lignans (2-4), were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-4) were subjected to an in vitro bioassay to evaluate their effects on vascular endothelial growth factor (VEGF)-induced vascular permeability and migration of human retinal endothelial cells (HRECs). Of the compounds tested, compound 1 resulted in the greatest reduction in VEGF-induced vascular permeability by about 31.5% at 10 mu M compared to the VEGF-treated control. In the migration assay, compounds 1 and 2 significantly decreased VEGF-induced HREC migration. Furthermore, zebrafish embryos treated with compounds 1 and 2 showed mild reductions of dorsal longitudinal anastomotic vessel (DLAV) formation.

KeywordLignans Scrophulariaceae Vascular Endothelial Growth Factor Zebrafish Brandisia Hancei
Subject AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry, Applied ; Food Science & Technology
DOI10.1080/09168451.2014.991687
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Chemistry ; Food Science & Technology
WOS IDWOS:000353479000008
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Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/20639
Collection中国科学院东亚植物多样性与生物地理学重点实验室
Corresponding AuthorKim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Dev Grp,Taejon,South Korea.; jskim@kiom.re.kr
Recommended Citation
GB/T 7714
Lee,Ik-Soo,Kim,Young Sook,Jung,Seung-Hyun,et al. Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish[J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2015,79(4):581-586.
APA Lee,Ik-Soo.,Kim,Young Sook.,Jung,Seung-Hyun.,Yu,Song Yi.,Kim,Joo-Hwan.,...&jskim@kiom.re.kr.(2015).Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,79(4),581-586.
MLA Lee,Ik-Soo,et al."Lignans from the stems and leaves of Brandisia hancei and their effects on VEGF-induced vascular permeability and migration of HRECs and DLAV formation in zebrafish".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 79.4(2015):581-586.
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