Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population
Li, X-L.1; Yu, H.2; Wu, G. -S.3; Wu,GS (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,134 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; wuguisheng@mail.kib.ac.cn
2014-12-01
发表期刊INTERNATIONAL JOURNAL OF IMMUNOGENETICS
ISSN1744-3121
卷号41期号:6页码:503-507
产权排序第一
摘要Psoriasis is a chronic inflammatory skin disease occurred under the interaction of genetic and environmental factors. The genes HLA complex P5 (HCP5), spermatogenesis associated 2 (SPATA2), tumour necrosis factor alpha-induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TNIP1) and the component of oligomeric Golgi complex 6 (COG6) were reported to be associated with psoriasis in western populations by genome-wide association studies. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. One single nucleotide polymorphism (SNP) from each gene was evaluated using Chinese patients with psoriasis (n=201) and controls (n=300). The results demonstrated that SNPs rs2395029, rs17728338 and rs610604 from the HCP5, TNIP1 and TNFAIP3 genes, respectively, were associated with psoriasis in the studied population at both genotype level and allelic level (P<0.05). Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations. These results provide potential makers for diagnosing, treating and preventing the psoriasis.
关键词Nmr-spectroscopy H-1-nmr Metabolites Joint 1d Qnmr Universal Concentration Reference Trimethylphosphine Oxide
资助信息National Natural Science Foundation of China [31300403]; National Natural Science Foundation of China [31300403]; China Postdoctoral Science Foundation [2013M540722]; China Postdoctoral Science Foundation [2013M540722]
学科领域Genetics & Heredity ; Immunology
DOI10.1111/iji.12150
收录类别SCI
语种英语
WOS研究方向Genetics & Heredity ; Immunology
WOS类目Genetics & Heredity ; Immunology
WOS记录号WOS:000345297600009
引用统计
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/18445
专题中国科学院东亚植物多样性与生物地理学重点实验室
通讯作者Wu,GS (reprint author),Chinese Acad Sci,State Key Lab Phytochem & Plant Resources West Ch,Kunming Inst Bot,134 Lanhei Rd,Kunming 650201,Yunnan,Peoples R China.; wuguisheng@mail.kib.ac.cn
作者单位1.Kunming Med Univ, Dept Dermatol & Rheumatol, Affiliated Yanan Hosp, Kunming, Yunnan, Peoples R China
2.Foshan Univ, Coll Life Sci, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
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Li, X-L.,Yu, H.,Wu, G. -S.,et al. Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population[J]. INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2014,41(6):503-507.
APA Li, X-L.,Yu, H.,Wu, G. -S.,Wu,GS ,&wuguisheng@mail.kib.ac.cn.(2014).Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population.INTERNATIONAL JOURNAL OF IMMUNOGENETICS,41(6),503-507.
MLA Li, X-L.,et al."Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population".INTERNATIONAL JOURNAL OF IMMUNOGENETICS 41.6(2014):503-507.
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