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题名: Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population
作者: Li, X-L.1; Yu, H.2; Wu, G. -S.3
刊名: INTERNATIONAL JOURNAL OF IMMUNOGENETICS
关键词: NMR-SPECTROSCOPY ; H-1-NMR ; METABOLITES ; joint 1D qNMR ; universal concentration reference ; trimethylphosphine oxide
英文摘要: Psoriasis is a chronic inflammatory skin disease occurred under the interaction of genetic and environmental factors. The genes HLA complex P5 (HCP5), spermatogenesis associated 2 (SPATA2), tumour necrosis factor alpha-induced protein 3 (TNFAIP3), TNFAIP3-interacting protein 1 (TNIP1) and the component of oligomeric Golgi complex 6 (COG6) were reported to be associated with psoriasis in western populations by genome-wide association studies. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. One single nucleotide polymorphism (SNP) from each gene was evaluated using Chinese patients with psoriasis (n=201) and controls (n=300). The results demonstrated that SNPs rs2395029, rs17728338 and rs610604 from the HCP5, TNIP1 and TNFAIP3 genes, respectively, were associated with psoriasis in the studied population at both genotype level and allelic level (P<0.05). Thus, the data suggested that HCP5, TNIP1 and TNFAIP3 may play a role in common pathogenic of psoriasis in Chinese and confer risk factors for psoriasis in various ethnic populations. These results provide potential makers for diagnosing, treating and preventing the psoriasis.
出版日期: 2014-12-01
卷号: 41, 期号:6, 页码:503-507
语种: 英语
收录类别: SCI
学科分类: Genetics & Heredity;Immunology
ISSN号: 1744-3121
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18445
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

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作者单位: 1.Kunming Med Univ, Dept Dermatol & Rheumatol, Affiliated Yanan Hosp, Kunming, Yunnan, Peoples R China
2.Foshan Univ, Coll Life Sci, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

Recommended Citation:
Li,X-L.;Yu,H.;Wu,G-S..Investigating the genetic association of HCP5, SPATA2, TNIP1, TNFAIP3 and COG6 with psoriasis in Chinese population,INTERNATIONAL JOURNAL OF IMMUNOGENETICS,2015,187(1):4137
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