Three new diterpenoids from Leonurus japonicus
Liu, Zhi-Ke1,3; Wu, Da-Rong2; Shi, Yi-Ming1,3; Zeng, Ting4,5; Liu, Shao-Hua2; Du, Xue1; Dang, Yong-Jun4,5; Xiao, Wei-Lie1; Sun, Han-Dong1

Phytochemical investigation of the aerial parts of Leonurus japonicus led to the isolation of one unusual clerodane diterpenoid, leojaponin A (1), characterized by a C-4-C-7 oxa-bridge, and two new labdane diterpenoids, leojaponins B (2) and C (3). The structures of these new compounds were determined based on extensive 1D and 2D NMR spectroscopic data. To the best of our knowledge, compound 1 is the first clerodane diterpenoid obtained from Leonurus. japonicus. All of them were evaluated for their cytotoxicity. (C) 2014 Tong-Jun Dang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

KeywordLeonurus Japonicus Leojaponin a Leojaponin b Leojaponin c
Indexed BySCI
WOS IDWOS:000337662000006
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Affiliation1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
2.Chengdu 1 Pharmaceut Grp Co Ltd, Chengdu 610031, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Fudan Univ, Shanghai Med Coll, Minist Educ, Key Lab Mol Med, Shanghai 200032, Peoples R China
5.Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China
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GB/T 7714
Liu, Zhi-Ke,Wu, Da-Rong,Shi, Yi-Ming,et al. Three new diterpenoids from Leonurus japonicus[J]. CHINESE CHEMICAL LETTERS,2014,25(5):677-679.
APA Liu, Zhi-Ke.,Wu, Da-Rong.,Shi, Yi-Ming.,Zeng, Ting.,Liu, Shao-Hua.,...&Sun, Han-Dong.(2014).Three new diterpenoids from Leonurus japonicus.CHINESE CHEMICAL LETTERS,25(5),677-679.
MLA Liu, Zhi-Ke,et al."Three new diterpenoids from Leonurus japonicus".CHINESE CHEMICAL LETTERS 25.5(2014):677-679.
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