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题名: Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System
作者: Chen, Hao1, 2; Jin, Min1, 2; Wang, Yi-Fen3; Wang, Yong-Qing2; Meng, Ling2; Li, Rong3; Wang, Jia-Ping3; Gao, Li3; Kong, Yi1; Wei, Ji-Fu2
刊名: BIOMED RESEARCH INTERNATIONAL
关键词: PLATELET-AGGREGATION ; THROMBIN ; HONGHUA
英文摘要: Toona microcarpa Harms is a tonic, antiperiodic, antirheumatic, and antithrombotic agent in China and India and an astringent and tonic for treating diarrhea, dysentery, and other intestinal infections in Indonesia. In this study, we prepared ethyl-acetate extract from the air-dried leaves of Toona microcarpa Harms and investigated the anticoagulant activities in vitro by performing activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) assays. Antiplatelet aggregation activity of the extract was examined using adenosine diphosphate (ADP), collagen, and thrombin as agonists, and the inhibitions of factor Xa and thrombin were also investigated. Bleeding and clotting times in mice were used to determine its anticoagulant activities in vivo. It is found that Toona microcarpa Harms leaf extract (TMHE) prolonged APTT, PT, and TT clotting times in a dose-dependent manner and significantly inhibited platelet aggregation induced by thrombin, but not ADP or collagen. Clotting time and bleeding time assays showed that TMHE significantly prolonged clotting and bleeding times in vivo. In addition, at the concentration of 1 mg/mL, TMHE inhibited human thrombin activity by 73.98 +/- 2.78%. This is the first report to demonstrate that THME exhibits potent anticoagulant effects, possibly via inhibition of thrombin activity.
出版日期: 2014
页码: 615363
DOI标识: 10.1155/2014/615363
语种: 英语
ISSN号: 2314-6133
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/18163
Appears in Collections:中国西南野生生物种质资源库_期刊论文

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作者单位: 1.China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China
2.Nanjing Med Univ, Affiliated Hosp 1, Res Div Clin Pharmacol, Nanjing 210029, Jiangsu, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Heilongtan 650201, Kunming, Peoples R China

Recommended Citation:
Chen,Hao;Jin,Min;Wang,Yi-Fen;Wang,Yong-Qing;Meng,Ling;Li,Rong;Wang,Jia-Ping;Gao,Li;Kong,Yi;Wei,Ji-Fu.Effect of Toona microcarpa Harms Leaf Extract on the Coagulation System,BIOMED RESEARCH INTERNATIONAL,2014,():615363
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