| Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo | |
Yu, Song Yi1; Lee, Ik-Soo1; Jung, Seung-Hyun1; Lee, Yun Mi1; Lee, Yu-Ri1; Kim, Joo-Hwan2; Sun, Hang3 ; Kim, Jin Sook1
| |
| 通讯作者 | Kim,JS (reprint author),Korea Inst Oriental Med,KM Based Herbal Drug Dev Grp,Herbal Med Res Div,Taejon 305811,South Korea. |
| 2013-12-01 | |
| 发表期刊 | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| 卷号 | 79期号:18页码:1705-1709 |
| 摘要 | In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-5) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation and rat lens aldose reductase activity. All tested compounds exhibited significant inhibition of advanced glycation end product formationwith IC50 values of 4.6-25.7 mu M, compared with those of aminoguanidine (IC50 = 1056 mu M) and quercetin (IC50 = 28.4 mu M) as positive controls. In the rat lens aldose reductase assay, acteoside, isoacteoside, and poliumoside exhibited greater inhibitory effects on rat lens aldose reductase with IC50 values of 0.83, 0.83, and 0.85 mu M, respectively, than those of the positive controls, 3,3-tetramethyleneglutaric acid (IC50= 4.03 mu M) and quercetin (IC50 = 7.2 mu M). In addition, the ef-fect of acteoside on the dilation of hyaloid-retinal vessels induced by high glucose in larval zebrafish was investigated. Acteoside reduced the diameters of high glucose-induced hyaloid-retinal vessels by 69% at 10 mu Mand 81% at 20 mu M, compared to the high glucose-treated control group. These results suggest that B. hancei and its active components might be beneficial in the treatment and prevention of diabetic vascular complications. |
| 关键词 | Brandisia Hancei Scrophulariaceae Phenylpropanoid Glycoside Advanced Glycation End-product Rat Lens Aldose Reductase Zebrafish Diabetic Vascular Complications |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000328696600003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17512 |
| 专题 | 中国科学院东亚植物多样性与生物地理学重点实验室 |
| 作者单位 | 1.Korea Inst Oriental Med, KM Based Herbal Drug Dev Grp, Herbal Med Res Div, Taejon 305811, South Korea 2.Kyungwon Univ, Dept Life Sci, Songnam, South Korea 3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Song Yi,Lee, Ik-Soo,Jung, Seung-Hyun,et al. Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo[J]. PLANTA MEDICA,2013,79(18):1705-1709. |
| APA | Yu, Song Yi.,Lee, Ik-Soo.,Jung, Seung-Hyun.,Lee, Yun Mi.,Lee, Yu-Ri.,...&Kim, Jin Sook.(2013).Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo.PLANTA MEDICA,79(18),1705-1709. |
| MLA | Yu, Song Yi,et al."Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo".PLANTA MEDICA 79.18(2013):1705-1709. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Caffeoylated Phenylp（143KB） | 开放获取 | CC BY-NC-SA | 浏览 下载 | |||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论