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题名: Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo
作者: Yu, Song Yi1; Lee, Ik-Soo1; Jung, Seung-Hyun1; Lee, Yun Mi1; Lee, Yu-Ri1; Kim, Joo-Hwan2; Sun Hang(孙航)3; Kim, Jin Sook1
刊名: PLANTA MEDICA
关键词: Brandisia hancei ; Scrophulariaceae ; phenylpropanoid glycoside ; advanced glycation end-product ; rat lens aldose reductase ; zebrafish ; diabetic vascular complications
英文摘要: In our continuing efforts to identify effective naturally sourced agents for diabetic complications, five caffeoylated phenylpropanoid glycosides, acteoside (1), isoacteoside (2), poliumoside (3), brandioside (4), and pheliposide (5) were isolated from the 80% EtOH extract of Brandisia hancei stems and leaves. These isolates (1-5) were subjected to an in vitro bioassay evaluating their inhibitory activity on advanced glycation end product formation and rat lens aldose reductase activity. All tested compounds exhibited significant inhibition of advanced glycation end product formationwith IC50 values of 4.6-25.7 mu M, compared with those of aminoguanidine (IC50 = 1056 mu M) and quercetin (IC50 = 28.4 mu M) as positive controls. In the rat lens aldose reductase assay, acteoside, isoacteoside, and poliumoside exhibited greater inhibitory effects on rat lens aldose reductase with IC50 values of 0.83, 0.83, and 0.85 mu M, respectively, than those of the positive controls, 3,3-tetramethyleneglutaric acid (IC50= 4.03 mu M) and quercetin (IC50 = 7.2 mu M). In addition, the ef-fect of acteoside on the dilation of hyaloid-retinal vessels induced by high glucose in larval zebrafish was investigated. Acteoside reduced the diameters of high glucose-induced hyaloid-retinal vessels by 69% at 10 mu Mand 81% at 20 mu M, compared to the high glucose-treated control group. These results suggest that B. hancei and its active components might be beneficial in the treatment and prevention of diabetic vascular complications.
出版日期: 2013-12-01
卷号: 79, 期号:18, 页码:1705-1709
语种: 英语
ISSN号: 0032-0943
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/17512
Appears in Collections:中国科学院东亚植物多样性与生物地理学重点实验室_期刊论文

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作者单位: 1.Korea Inst Oriental Med, KM Based Herbal Drug Dev Grp, Herbal Med Res Div, Taejon 305811, South Korea
2.Kyungwon Univ, Dept Life Sci, Songnam, South Korea
3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming, Yunnan, Peoples R China
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文件名: Caffeoylated Phenylpropanoid Glycosides from Brandisia hancei Inhibit Advanced Glycation End Product Formation and Aldose Reductase in Vitro and Vessel Dilation in Larval Zebrafish in Vivo.pdf
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