| Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo | |
Lee, Ik-Soo1; Yu, Song Yi1; Jung, Seung-Hyun1; Lee, Yu-Ri1; Lee, Yun Mi1; Kim, Joo-Hwan2; Sun, Hang3 ; Kim, Jin Sook1
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| 通讯作者 | Kim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Res Grp,Taejon 305811,South Korea.,jskim@kiom.re.kr |
| 2013-10-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 76期号:10页码:1881-1888 |
| 摘要 | Three new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group. |
| 关键词 | A-type Proanthocyanidins Prunus-armeniaca Roots End-products Ages Circular-dichroism Protein Glycation Peanut Skins Flavonoids Tannins |
| 学科领域 | Plant Sciences ; Pharmacology & Pharmacy |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000326319700009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/17425 |
| 专题 | 中国科学院东亚植物多样性与生物地理学重点实验室 |
| 作者单位 | 1.Korea Inst Oriental Med, Herbal Med Res Div, KM Based Herbal Drug Res Grp, Taejon 305811, South Korea 2.Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea 3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming 650204, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lee, Ik-Soo,Yu, Song Yi,Jung, Seung-Hyun,et al. Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(10):1881-1888. |
| APA | Lee, Ik-Soo.,Yu, Song Yi.,Jung, Seung-Hyun.,Lee, Yu-Ri.,Lee, Yun Mi.,...&Kim, Jin Sook.(2013).Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo.JOURNAL OF NATURAL PRODUCTS,76(10),1881-1888. |
| MLA | Lee, Ik-Soo,et al."Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo".JOURNAL OF NATURAL PRODUCTS 76.10(2013):1881-1888. |
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