Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
Lee, Ik-Soo1; Yu, Song Yi1; Jung, Seung-Hyun1; Lee, Yu-Ri1; Lee, Yun Mi1; Kim, Joo-Hwan2; Sun, Hang3; Kim, Jin Sook1
Corresponding AuthorKim,JS (reprint author),Korea Inst Oriental Med,Herbal Med Res Div,KM Based Herbal Drug Res Grp,Taejon 305811,South Korea.,jskim@kiom.re.kr
2013-10-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume76Issue:10Pages:1881-1888
AbstractThree new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group.
KeywordA-type Proanthocyanidins Prunus-armeniaca Roots End-products Ages Circular-dichroism Protein Glycation Peanut Skins Flavonoids Tannins
Subject AreaPlant Sciences ; Pharmacology & Pharmacy
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000326319700009
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/17425
Collection中国科学院东亚植物多样性与生物地理学重点实验室
Affiliation1.Korea Inst Oriental Med, Herbal Med Res Div, KM Based Herbal Drug Res Grp, Taejon 305811, South Korea
2.Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea
3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming 650204, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Lee, Ik-Soo,Yu, Song Yi,Jung, Seung-Hyun,et al. Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(10):1881-1888.
APA Lee, Ik-Soo.,Yu, Song Yi.,Jung, Seung-Hyun.,Lee, Yu-Ri.,Lee, Yun Mi.,...&Kim, Jin Sook.(2013).Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo.JOURNAL OF NATURAL PRODUCTS,76(10),1881-1888.
MLA Lee, Ik-Soo,et al."Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo".JOURNAL OF NATURAL PRODUCTS 76.10(2013):1881-1888.
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