Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo
Lee, Ik-Soo1; Yu, Song Yi1; Jung, Seung-Hyun1; Lee, Yu-Ri1; Lee, Yun Mi1; Kim, Joo-Hwan2; Sun, Hang3; Kim, Jin Sook1
2013-10-01
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号76期号:10页码:1881-1888
摘要Three new A-type proanthocyanidins (1-3), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin 3'-O-beta-D-glycopyranoside (1), ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (2), and ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8) -ent-epiafzelechin-(2 alpha -> O -> 7,4 alpha -> 8)-ent-afzelechin (3), and three known compounds (4-6) were isolated from the whole plant of Spenceria ramalana. The structures of the new proanthocyanidins were established by spectroscopic and chemical studies. The inhibitory effects of compounds 1-6 on the formation of advanced glycation end products were examined in vitro. Compounds 3 and 6 showed the strongest inhibition, with IC50 values of 17.4 +/- 0.5 and 14.1 +/- 1.6 mu M, respectively. The effects of these isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish were also investigated. Compound 3 reduced the dilation of HG-induced hyaloid-retinal vessels most effectively. This compound reduced the diameters of HG-induced hyaloid-retinal vessels by about 157.7% and 164.1% at 10 and 20 mu M, respectively, versus the HG-treated control group.
关键词A-type Proanthocyanidins Prunus-armeniaca Roots End-products Ages Circular-dichroism Protein Glycation Peanut Skins Flavonoids Tannins
资助信息Korea Institute of Oriental Medicine [K12040, K13040]
学科领域Plant Sciences ; Pharmacology & Pharmacy
收录类别SCI
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000326319700009
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/17425
专题中国科学院东亚植物多样性与生物地理学重点实验室
作者单位1.Korea Inst Oriental Med, Herbal Med Res Div, KM Based Herbal Drug Res Grp, Taejon 305811, South Korea
2.Gachon Univ, Dept Life Sci, Songnam 461701, Gyeonggi Do, South Korea
3.Chinese Acad Sci, Kunming Inst Bot, Lab Biodivers & Biogeog, Kunming 650204, Yunnan, Peoples R China
推荐引用方式
GB/T 7714
Lee, Ik-Soo,Yu, Song Yi,Jung, Seung-Hyun,et al. Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo[J]. JOURNAL OF NATURAL PRODUCTS,2013,76(10):1881-1888.
APA Lee, Ik-Soo.,Yu, Song Yi.,Jung, Seung-Hyun.,Lee, Yu-Ri.,Lee, Yun Mi.,...&Kim, Jin Sook.(2013).Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo.JOURNAL OF NATURAL PRODUCTS,76(10),1881-1888.
MLA Lee, Ik-Soo,et al."Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo".JOURNAL OF NATURAL PRODUCTS 76.10(2013):1881-1888.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Lee-2013-Proanthocya(397KB)期刊论文出版稿开放获取CC BY-NC-SA请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Lee, Ik-Soo]的文章
[Yu, Song Yi]的文章
[Jung, Seung-Hyun]的文章
百度学术
百度学术中相似的文章
[Lee, Ik-Soo]的文章
[Yu, Song Yi]的文章
[Jung, Seung-Hyun]的文章
必应学术
必应学术中相似的文章
[Lee, Ik-Soo]的文章
[Yu, Song Yi]的文章
[Jung, Seung-Hyun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。