| 毛钉菇等6种高等真菌化学成分研究 |
| 牛芸
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| 学位类型 | 硕士
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| 导师 | 刘吉开
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| 2010-05
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| 学位授予单位 | 中国科学院研究生院
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| 学位专业 | 植物学
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| 摘要 | 本文研究了6种采自云南的高等真菌发酵液及一种植物的化学成分，他们包括毛钉菇(Gomphus floccosus)、大皮伞(Marasmius maximus Hongo)、耳状网褶菌(Paxillus panuoides)、苦粉孢牛肝菌(Tylopilus felleus)、鸡油菌(Cantharellus cibarius)、灰树花(Grifola frondosa)以及植物匍枝金丝桃(Hypericum reptans)。运用多种分离与分析方法（CC、TLC、prep. TLC、MPLC、HPLC 等）以及波谱学技术（1D NMR、2D NMR、MS、HR-MS、UV/Vis 等）并借助必要的化学手段和X-晶体衍射手段，共分离鉴定43个化合物，其中38个各不相同的化合物，新化合物3个。从毛钉菇(Gomphus floccosus)发酵液中分离得到了呋喃酮类衍生物，其中2个为新化合物，分子结构中存在较大的共轭系统，被分别确定为(E)-3-(1,3-butadienyl)-4-(3-oxopentyl)-2(5H)-furanone (1)、3-((S,E)-3,4-dihydroxy-butylenyl)-4-((S,E)-3-hydroxy-pentenyl)-2(5H)-furanone (2)。其中的化合物2通过化学方法选择性保护邻二羟基中的伯醇羟基，进而通过改进的Mosher方法确定其支链上手性碳的绝对构型。对植物匍枝金丝桃(Hypericum reptans)进行了阶段性研究，已分离得到一个结构新颖的以二苯并二氧杂苯为骨架的化合物，通过X-晶体衍射确定其分子结构和相对构型。 |
| 资助项目 | The chemical constituents of six higher fungi including Gomphus floccosus, Marasmius maximus Hongo, Paxillus panuoides, Tylopilus felleus, Cantharellus cibarius and Grifola frondosa collected from Yunnan Province, P. R. China, and a medicinal plant Hypericum reptans, were investigated.43 Compounds including 3 new ones have been obtained by chromatographic methods, and their structures were elucidated on the basis of spectroscopic data (1D NMR, 2D NMR, MS, HR-MS, UV/Vis) in combination with single-crystal X-ray diffraction analysis.Two new furanone derivatives, (E)-3-(1,3-butadienyl)-4-(3-oxopentyl)-2(5H)-furanone (1), 3-((S,E)-3,4-dihydroxy-butylenyl)-4-((S,E)-3-hydroxy-pentenyl)-2(5H)-furanone (2) which had a large conjugated systemGomphus floccosus. The absolute configurations of 2 were determined based on the modified Moshers method after selectively protected the primary alcohol group in the 1,2-primary/secondary diol. in the structures, were isolated from the culture of the basidiomycete. A new compound based on a dibenzodioxinone skeleton was isolated from the medical plant Hypericum reptans. The plane structure and relative configurations of the new compound was elucidated by spectroscopic data and further confirmed by single-crystal X-ray diffraction.
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| 语种 | 中文
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| 文献类型 | 学位论文
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| 条目标识符 | http://ir.kib.ac.cn/handle/151853/16066
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| 专题 | 昆明植物所硕博研究生毕业学位论文
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推荐引用方式
GB/T 7714 |
牛芸. 毛钉菇等6种高等真菌化学成分研究[D]. 中国科学院研究生院,2010.
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