| Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii | |
Tang, Gui-Hua1,2 ; Zhang, Yu1; Yuan, Chun-Mao1; Li, Yan1; Gu, Yu-Cheng3; Di, Ying-Tong1; Wang, Yue-Hu4; Zuo, Guo-Ying5; Li, Shi-Fei1,2; Li, Shun-Lin1; He, Hong-Ping1; Hao, Xiao-Jiang1
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| 通讯作者 | He, HP (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China.,hehongping@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn |
| 2012-11-01 | |
| 发表期刊 | JOURNAL OF NATURAL PRODUCTS
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| ISSN | 0163-3864 |
| 卷号 | 75期号:11页码:1962-1966 |
| 摘要 | Two new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 mu M Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 mu g/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method. |
| 关键词 | Daphnane-type Diterpenoids Chinensis Heterophyllus Reidioides Alkaloids |
| 学科领域 | Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
| DOI | 10.1021/np3006315 |
| 收录类别 | SCI ; IC |
| 语种 | 英语 |
| WOS记录号 | WOS:000311461300014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kib.ac.cn/handle/151853/15924 |
| 专题 | 植物化学与西部植物资源持续利用国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China 5.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Gui-Hua,Zhang, Yu,Yuan, Chun-Mao,et al. Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1962-1966. |
| APA | Tang, Gui-Hua.,Zhang, Yu.,Yuan, Chun-Mao.,Li, Yan.,Gu, Yu-Cheng.,...&Hao, Xiao-Jiang.(2012).Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii.JOURNAL OF NATURAL PRODUCTS,75(11),1962-1966. |
| MLA | Tang, Gui-Hua,et al."Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1962-1966. |
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