Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii
Tang, Gui-Hua1,2; Zhang, Yu1; Yuan, Chun-Mao1; Li, Yan1; Gu, Yu-Cheng3; Di, Ying-Tong1; Wang, Yue-Hu4; Zuo, Guo-Ying5; Li, Shi-Fei1,2; Li, Shun-Lin1; He, Hong-Ping1; Hao, Xiao-Jiang1
Corresponding AuthorHe, HP (reprint author), Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China.,hehongping@mail.kib.ac.cn ; haoxj@mail.kib.ac.cn
2012-11-01
Source PublicationJOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
Volume75Issue:11Pages:1962-1966
AbstractTwo new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 mu M Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 mu g/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method.
KeywordDaphnane-type Diterpenoids Chinensis Heterophyllus Reidioides Alkaloids
Subject AreaPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np3006315
Indexed BySCI ; IC
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000311461300014
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15924
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
3.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
4.Chinese Acad Sci, Kunming Inst Bot, Key Lab Econ Plants & Biotechnol, Kunming 650201, Yunnan, Peoples R China
5.Chengdu Mil Command, Kunming Gen Hosp, Sch Clin, Res Ctr Nat Med, Kunming 650032, Yunnan, Peoples R China
Recommended Citation
GB/T 7714
Tang, Gui-Hua,Zhang, Yu,Yuan, Chun-Mao,et al. Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(11):1962-1966.
APA Tang, Gui-Hua.,Zhang, Yu.,Yuan, Chun-Mao.,Li, Yan.,Gu, Yu-Cheng.,...&Hao, Xiao-Jiang.(2012).Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii.JOURNAL OF NATURAL PRODUCTS,75(11),1962-1966.
MLA Tang, Gui-Hua,et al."Trigohowilols A-G, Degraded Diterpenoids from the Stems of Trigonostemon howii".JOURNAL OF NATURAL PRODUCTS 75.11(2012):1962-1966.
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