Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas
Wu, Mingyi1; Huang, Rong2; Wen, Dandan1,3; Gao, Na1; He, Jiangbo1; Li, Zi1; Zhao, Jinhua1
2012-01-04
Source PublicationCARBOHYDRATE POLYMERS
Volume87Issue:1Pages:862-868
AbstractFucosylated chondroitin sulfate (FuCS) is a glycosaminoglycan from sea cucumber, made up of alternating beta-D-glucuronic acid and N-acetyl-beta-D-galactosamine units. The beta-D-glucuronic acid residues have branches of sulfated fucose, while the fucose branches may have distinguishable patterns and proportions of sulfate substitution. The structure of the sulfated fucose branches of the fucosylated chondroitin sulfate from the sea cucumber Thelenata ananas has been characterized by mild acid hydrolysis and NMR technology. The results showed that the fucose residues are made up of 3-,4-mono-O-sulfated fucose and 2,4-di-O-sulfated fucose with about 25:22:53, respectively. The sulfated fucose branches are essential for the anticoagulant action of FuCS, and this potent effect is possibly related to the occurrence of 2,4-di-O-sulfated fucose units. Furthermore, these branches could constitute the structural requirement for the binding of the glycosaminoglycan to coagulant enzymes, such as thrombin by HCII, factor X by the intrinsic tenase complex. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
KeywordSea Cucumber Fucosylated Chondroitin Sulfate Sulfated Fucose Anticoagulant Activity
DOI10.1016/j.carbpol.2011.08.082
Indexed BySCI
Language英语
WOS IDWOS:000297389000114
Citation statistics
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/15898
Collection植物化学与西部植物资源持续利用国家重点实验室
Affiliation1.Chinese Acad Sci, Kuming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kuming, Peoples R China
2.Yunan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kuming, Peoples R China
3.Sun Yat Sen Univ, Sch Parmaceut Sci, Guangzhou, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Wu, Mingyi,Huang, Rong,Wen, Dandan,et al. Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas[J]. CARBOHYDRATE POLYMERS,2012,87(1):862-868.
APA Wu, Mingyi.,Huang, Rong.,Wen, Dandan.,Gao, Na.,He, Jiangbo.,...&Zhao, Jinhua.(2012).Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas.CARBOHYDRATE POLYMERS,87(1),862-868.
MLA Wu, Mingyi,et al."Structure and effect of sulfated fucose branches on anticoagulant activity of the fucosylated chondroitin sulfate from sea cucumber Thelenata ananas".CARBOHYDRATE POLYMERS 87.1(2012):862-868.
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