Further investigation on the leaves of Isodon sculponeatus afforded two new ent-kaurane diterpenoids, sculponeatins J and K. Their structures were elucidated on the basis of their spectral properties, as well as X-ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC50 values less than 1.0 mug/ mL.
1.Acad Sinica, State Key Lab Physochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China 2.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China 3.Dali Coll, Dept Pharmaceut, Dali 671000, Yunnan, Peoples R China
Recommended Citation:
Jiang, B; Mei, SX; Zhao, AH; Sun, HD; Lu, Y; Zhang, QT.Diterpenoids from Isodon sculponeatus,CHINESE JOURNAL OF CHEMISTRY,2002,20(9):887-890
