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题名: CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS
作者: YUE, XF ; HAN, JX ; SHEN, ZM ; YANG, WY ; LU, LJ ; LI, BJ ; WANG, C ; XU, XK
刊名: ACTA PHARMACOLOGICA SINICA
关键词: TREWIASINE ; MAYTANSINE ; CULTURED TUMOR CELLS ; EXPERIMENTAL NEOPLASMS ; PHYTOGENIC ANTINEOPLASTIC AGENTS
英文摘要: Trewiasine (TWS) is a mytansinoid compound. It possessed a significant cytotoxic activity against various human cancer cell lines in vitro. U937 cells, which were more sensitive to the TWS, required TWS 1-mu-g . ml-1 to inhibit cell growth over 90% (P < 0.01). TWS also showed activities against murine tumors in vivo, such as the ascitic tumors S180, hepatoma, U14, and solid tumor Lewis lung carcinoma. Depression of leukocytes was not seen when mice were given ip TWS 10 or 50-mu-g . kg-1 . d-1 x 7 d. TWS 0.1-1-mu-g . ml-1 caused no sister chromatid exchange induction in Chinese hamster cell line V79.
出版日期: 1992
卷号: 13, 期号:3, 页码:252-255
语种: 英语
收录类别: sci
学科分类: Chemistry, Multidisciplinary; Pharmacology & Pharmacy
ISSN号: 0253-9756
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/14377
Appears in Collections:离退休_期刊论文

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Recommended Citation:
YUE, XF; HAN, JX; SHEN, ZM; YANG, WY; LU, LJ; LI, BJ; WANG, C; XU, XK.CYTOTOXIC ACTIVITY OF TREWIASINE IN 4 HUMAN CANCER CELL-LINES AND 5 MURINE TUMORS,ACTA PHARMACOLOGICA SINICA,1992,13(3):252-255
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