Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance

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	Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance
	Gao, GH ; Liu, W ; Dai, JX ; Wang, JF ; Hu, Z ; Zhang, Y; Wang, DC
	2001-12-10
发表期刊	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN	0141-8130
卷号	29 期号:4-5 页码:251-258
摘要	The antifungal peptide from seeds of Phytolacca Americana (Pokeweed), designated PAFP-S hereinafter, is a recently found cationic peptide which consists of 38 amino acid residues and exihibites a broad spectrum of antifungal activity, including inhibition of certain saprophytic fungi and some plant pathogens. The secondary structure and three cysteine pairings have been investigated by H-1 NMR analysis. The results show that the molecular scaffold of PAFP-S features a triple-stranded antiparallel beta -sheet knotted by a typical disulfide bridge motif, which characterizes the knottin fold. CD spectroscopy indicates a high stability of the molecule in solution. Therefore, PAFP-S should be a new member of the knottin structural family and the first antifungal peptide that adopts the knottin-like fold. (C) 2001 Elsevier Science B.V. All rights reserved.
关键词	Antifungal Peptides Secondary Structure Cysteine Pairing Knottin-like Peptide
学科领域	Biochemistry & Molecular Biology
收录类别	SCI
语种	英语
WOS记录号	WOS:000172670700005
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/14227
专题	离退休
作者单位	1.Acad Sinica, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Acad Sinica, Inst Biophys, Lab Mol Biophys, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Gao, GH,Liu, W,Dai, JX,et al. Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2001,29(4-5):251-258.
APA	Gao, GH.,Liu, W.,Dai, JX.,Wang, JF.,Hu, Z.,...&Wang, DC.(2001).Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,29(4-5),251-258.
MLA	Gao, GH,et al."Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 29.4-5(2001):251-258.

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