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Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance
Gao, GH; Liu, W; Dai, JX; Wang, JF; Hu, Z; Zhang, Y; Wang, DC
2001-12-10
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume29Issue:4-5Pages:251-258
AbstractThe antifungal peptide from seeds of Phytolacca Americana (Pokeweed), designated PAFP-S hereinafter, is a recently found cationic peptide which consists of 38 amino acid residues and exihibites a broad spectrum of antifungal activity, including inhibition of certain saprophytic fungi and some plant pathogens. The secondary structure and three cysteine pairings have been investigated by H-1 NMR analysis. The results show that the molecular scaffold of PAFP-S features a triple-stranded antiparallel beta -sheet knotted by a typical disulfide bridge motif, which characterizes the knottin fold. CD spectroscopy indicates a high stability of the molecule in solution. Therefore, PAFP-S should be a new member of the knottin structural family and the first antifungal peptide that adopts the knottin-like fold. (C) 2001 Elsevier Science B.V. All rights reserved.
KeywordAntifungal Peptides Secondary Structure Cysteine Pairing Knottin-like Peptide
Subject AreaBiochemistry & Molecular Biology
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology
WOS SubjectBiochemistry & Molecular Biology
WOS IDWOS:000172670700005
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/14227
Collection离退休
Affiliation1.Acad Sinica, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
2.Acad Sinica, Inst Biophys, Lab Mol Biophys, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Peoples R China
Recommended Citation
GB/T 7714
Gao, GH,Liu, W,Dai, JX,et al. Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2001,29(4-5):251-258.
APA Gao, GH.,Liu, W.,Dai, JX.,Wang, JF.,Hu, Z.,...&Wang, DC.(2001).Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,29(4-5),251-258.
MLA Gao, GH,et al."Molecular scaffold of a new pokeweed antifungal peptide deduced by H-1 nuclear magnetic resonance".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 29.4-5(2001):251-258.
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