Harnessing the potential of chemical defenses from antimicrobial activities

doi:10.1002/bies.20060

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	Harnessing the potential of chemical defenses from antimicrobial activities
	Lu, CH ; Shen, YM
通讯作者	yshen@mail.kib.ac.cn
	2004-07-01
发表期刊	BIOESSAYS
ISSN	0265-9247
卷号	26 期号:7 页码:808-813
摘要	Resistance to the drugs used in the treatment of many infectious diseases is increasing, while microbial infections are being found to be responsible for more life-threatening diseases than previously thought. Despite a large investment in the invention and application of high-throughput screening techniques involving miniaturization and automation, and a diverse array of strategies for designing and constructing various chemical libraries, relatively few new drugs have resulted. Natural products, however, have been a majorsource of drugs for centuries. Since some of them are produced by organisms as a result of selection in favour of improved defense against competing deleterious microorganisms, in principle they would be less likely to incur resistance. Furthermore, the production of those defensive secondary metabolites is inducible because their original function is a response to environmental challenges. Moreover, symbioses, cohabitation associations between two or more different species of organisms, are universal in nature, and the production of secondary metabolites by symbiotic microbes may be an important adaptation allowing microbes to affect their hosts. Therefore, co-culture strategies, using combinations of plant cell-pathogenic microbes, plant cell-endophytes (or symbionts), and symbiont-pathogenic microbes, based on the principles of chemical defense and the known mechanisms of organism interactions, may be an efficient general approach in the search for new anti-microbial drugs. (C) 2004 Wiley Periodicals, Inc.
学科领域	Biochemistry & Molecular Biology ; Biology
DOI	10.1002/bies.20060
收录类别	SCI
语种	英语
WOS记录号	WOS:000222494300014
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13527
专题	离退休
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, Stae Key Lab Phytochem & Plant Resources W China, Kunming 650204, Yunnan, Peoples R China 2.Xiamen Univ, Sch Life Sci, Xiamen, Peoples R China
推荐引用方式 GB/T 7714	Lu, CH,Shen, YM. Harnessing the potential of chemical defenses from antimicrobial activities[J]. BIOESSAYS,2004,26(7):808-813.
APA	Lu, CH,&Shen, YM.(2004).Harnessing the potential of chemical defenses from antimicrobial activities.BIOESSAYS,26(7),808-813.
MLA	Lu, CH,et al."Harnessing the potential of chemical defenses from antimicrobial activities".BIOESSAYS 26.7(2004):808-813.

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