Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum

doi:10.1021/np0202778

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	Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum
	Wang, CY ; Wang, BG ; Wiryowidagdo, S ; Wray, V ; van Soest, R ; Steube, KG ; Guan, HS ; Proksch, P ; Ebel, R
通讯作者	ebel@uni-duesseldorf.de
	2003
发表期刊	JOURNAL OF NATURAL PRODUCTS
ISSN	0163-3864
卷号	66 期号:1 页码:51-56
摘要	Thirteen new metabolites, melophlins C-O (1-13), were identified from the marine sponge Melophlus sarassinorum. Compounds 1-13 represent tetramic acid derivatives that differ with regard to the nature of their alkyl side chains. The structures of the new compounds were elucidated on the basis of comprehensive spectral analysis (H-1, C-13, H-1-H-1 COSY, HMQC, and HMBC NMR, as well as low- and high-resolution ESIMS and EIMS). The absolute configurations of 1, 8, 10, 11, 12, and 13 were determined by ESI LC/MS analysis of chiral derivatives obtained upon oxidation and hydrolysis of the respective parent compounds. Melophlin C (1) displayed pronounced antibacterial activity against Bacillus subtilis and Staphylococcus aureus, together with antifungal activity against Candida albicans.
学科领域	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI	10.1021/np0202778
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000180623400012
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/13465
专题	离退休
作者单位	1.Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany 2.Univ Indonesia, Ctr Marine Studies, Depok 16424, Indonesia 3.Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany 4.Univ Amsterdam, Zool Museum, NL-1092 AD Amsterdam, Netherlands 5.Deutsch Sammlung Mikroorganismen & Zellkulturen G, D-38124 Braunschweig, Germany 6.Ocean Univ Qingdao, Marine Drug & Food Inst, Qingdao 266003, Peoples R China 7.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, CY,Wang, BG,Wiryowidagdo, S,et al. Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum[J]. JOURNAL OF NATURAL PRODUCTS,2003,66(1):51-56.
APA	Wang, CY.,Wang, BG.,Wiryowidagdo, S.,Wray, V.,van Soest, R.,...&Ebel, R.(2003).Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum.JOURNAL OF NATURAL PRODUCTS,66(1),51-56.
MLA	Wang, CY,et al."Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum".JOURNAL OF NATURAL PRODUCTS 66.1(2003):51-56.

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