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Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum
Wang, CY; Wang, BG; Wiryowidagdo, S; Wray, V; van Soest, R; Steube, KG; Guan, HS; Proksch, P; Ebel, R
2003
发表期刊JOURNAL OF NATURAL PRODUCTS
ISSN0163-3864
卷号66期号:1页码:51-56
摘要Thirteen new metabolites, melophlins C-O (1-13), were identified from the marine sponge Melophlus sarassinorum. Compounds 1-13 represent tetramic acid derivatives that differ with regard to the nature of their alkyl side chains. The structures of the new compounds were elucidated on the basis of comprehensive spectral analysis (H-1, C-13, H-1-H-1 COSY, HMQC, and HMBC NMR, as well as low- and high-resolution ESIMS and EIMS). The absolute configurations of 1, 8, 10, 11, 12, and 13 were determined by ESI LC/MS analysis of chiral derivatives obtained upon oxidation and hydrolysis of the respective parent compounds. Melophlin C (1) displayed pronounced antibacterial activity against Bacillus subtilis and Staphylococcus aureus, together with antifungal activity against Candida albicans.
学科领域Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
DOI10.1021/np0202778
收录类别SCI ; IC
语种英语
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
WOS类目Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS记录号WOS:000180623400012
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/13465
专题离退休
作者单位1.Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany
2.Univ Indonesia, Ctr Marine Studies, Depok 16424, Indonesia
3.Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
4.Univ Amsterdam, Zool Museum, NL-1092 AD Amsterdam, Netherlands
5.Deutsch Sammlung Mikroorganismen & Zellkulturen G, D-38124 Braunschweig, Germany
6.Ocean Univ Qingdao, Marine Drug & Food Inst, Qingdao 266003, Peoples R China
7.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China
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Wang, CY,Wang, BG,Wiryowidagdo, S,et al. Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum[J]. JOURNAL OF NATURAL PRODUCTS,2003,66(1):51-56.
APA Wang, CY.,Wang, BG.,Wiryowidagdo, S.,Wray, V.,van Soest, R.,...&Ebel, R.(2003).Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum.JOURNAL OF NATURAL PRODUCTS,66(1),51-56.
MLA Wang, CY,et al."Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum".JOURNAL OF NATURAL PRODUCTS 66.1(2003):51-56.
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