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题名: Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum
作者: Wang, CY; Wang, BG; Wiryowidagdo, S; Wray, V; van Soest, R; Steube, KG; Guan, HS; Proksch, P; Ebel, R
刊名: JOURNAL OF NATURAL PRODUCTS
英文摘要: Thirteen new metabolites, melophlins C-O (1-13), were identified from the marine sponge Melophlus sarassinorum. Compounds 1-13 represent tetramic acid derivatives that differ with regard to the nature of their alkyl side chains. The structures of the new compounds were elucidated on the basis of comprehensive spectral analysis (H-1, C-13, H-1-H-1 COSY, HMQC, and HMBC NMR, as well as low- and high-resolution ESIMS and EIMS). The absolute configurations of 1, 8, 10, 11, 12, and 13 were determined by ESI LC/MS analysis of chiral derivatives obtained upon oxidation and hydrolysis of the respective parent compounds. Melophlin C (1) displayed pronounced antibacterial activity against Bacillus subtilis and Staphylococcus aureus, together with antifungal activity against Candida albicans.
出版日期: 2003
卷号: 66, 期号:1, 页码:51-56
DOI标识: 10.1021/np0202778
语种: 英语
ISSN号: 0163-3864
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内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/13465
Appears in Collections:离退休_期刊论文

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作者单位: 1.Univ Dusseldorf, Inst Pharmazeut Biol, D-40225 Dusseldorf, Germany
2.Univ Indonesia, Ctr Marine Studies, Depok 16424, Indonesia
3.Gesell Biotechnol Forsch mbH, D-38124 Braunschweig, Germany
4.Univ Amsterdam, Zool Museum, NL-1092 AD Amsterdam, Netherlands
5.Deutsch Sammlung Mikroorganismen & Zellkulturen G, D-38124 Braunschweig, Germany
6.Ocean Univ Qingdao, Marine Drug & Food Inst, Qingdao 266003, Peoples R China
7.Chinese Acad Sci, Lab Phytochem, Kunming Inst Bot, Kunming 650204, Peoples R China

Recommended Citation:
Wang, CY; Wang, BG; Wiryowidagdo, S; Wray, V; van Soest, R; Steube, KG; Guan, HS; Proksch, P; Ebel, R.Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum,JOURNAL OF NATURAL PRODUCTS,2003,66(1):51-56
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