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SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
Guo, Zhenhua2; Adomas, Aleksandra B.1; Jackson, Erin D.3; Qin, Hong3; Townsend, Jeffrey P.1
2011-06-01
Source PublicationFEMS YEAST RESEARCH
Volume11Issue:4Pages:345-355
AbstractWe investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention.
KeywordTranscriptomics Longevity Gene Expression Microarray Life Span Variation
Subject AreaBiotechnology & Applied Microbiology ; Microbiology ; Mycology
DOI10.1111/j.1567-1364.2011.00723.x
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Microbiology ; Mycology
WOS SubjectBiotechnology & Applied Microbiology ; Microbiology ; Mycology
WOS IDWOS:000290408800004
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.kib.ac.cn/handle/151853/11219
Collection中国西南野生生物种质资源库
Affiliation1.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA
2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Beijing 100864, Peoples R China
3.Spelman Coll, Dept Biol, Atlanta, GA 30314 USA
Recommended Citation
GB/T 7714
Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,et al. SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae[J]. FEMS YEAST RESEARCH,2011,11(4):345-355.
APA Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,Qin, Hong,&Townsend, Jeffrey P..(2011).SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.FEMS YEAST RESEARCH,11(4),345-355.
MLA Guo, Zhenhua,et al."SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae".FEMS YEAST RESEARCH 11.4(2011):345-355.
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