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题名: SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
作者: null(郭振华)2; Adomas, Aleksandra B.1; Jackson, Erin D.3; Qin, Hong3; Townsend, Jeffrey P.1
刊名: FEMS YEAST RESEARCH
关键词: transcriptomics ; longevity ; gene expression ; microarray ; life span ; variation
英文摘要: We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention.
出版日期: 2011-06-01
卷号: 11, 期号:4, 页码:345-355
语种: 英语
收录类别: SCI
学科分类: Biotechnology & Applied Microbiology; Microbiology; Mycology
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.kib.ac.cn/handle/151853/11219
Appears in Collections:中国西南野生生物种质资源库_期刊论文

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作者单位: 1.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA
2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Beijing 100864, Peoples R China
3.Spelman Coll, Dept Biol, Atlanta, GA 30314 USA

Recommended Citation:
Guo, ZH; Adomas, AB; Jackson, ED; Qin, H; Townsend, JP.SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae,FEMS YEAST RESEARCH,2011,11(4):345-355
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