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SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae
Guo, Zhenhua2; Adomas, Aleksandra B.1; Jackson, Erin D.3; Qin, Hong3; Townsend, Jeffrey P.1
2011-06-01
发表期刊FEMS YEAST RESEARCH
卷号11期号:4页码:345-355
摘要We investigated the mechanism underlying the natural variation in longevity within natural populations using the model budding yeast, Saccharomyces cerevisiae. We analyzed whole-genome gene expression in four progeny of a natural S. cerevisiae strain that display differential replicative aging. Genes with different expression levels in short- and long-lived strains were classified disproportionately into metabolism, transport, development, transcription or cell cycle, and organelle organization (mitochondrial, chromosomal, and cytoskeletal). With several independent validating experiments, we detected 15 genes with consistent differential expression levels between the long- and the short-lived progeny. Among those 15, SIR2, HSP30, and TIM17 were upregulated in long-lived strains, which is consistent with the known effects of gene silencing, stress response, and mitochondrial function on aging. The link between SIR2 and yeast natural life span variation offers some intriguing ties to the allelic association of the human homolog SIRT1 to visceral obesity and metabolic response to lifestyle intervention.
关键词Transcriptomics Longevity Gene Expression Microarray Life Span Variation
学科领域Biotechnology & Applied Microbiology ; Microbiology ; Mycology
DOI10.1111/j.1567-1364.2011.00723.x
收录类别SCI
语种英语
WOS研究方向Biotechnology & Applied Microbiology ; Microbiology ; Mycology
WOS类目Biotechnology & Applied Microbiology ; Microbiology ; Mycology
WOS记录号WOS:000290408800004
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.kib.ac.cn/handle/151853/11219
专题中国西南野生生物种质资源库
作者单位1.Yale Univ, Dept Ecol & Evolutionary Biol, New Haven, CT 06520 USA
2.Chinese Acad Sci, Kunming Inst Bot, Germplasm Bank Wild Species, Beijing 100864, Peoples R China
3.Spelman Coll, Dept Biol, Atlanta, GA 30314 USA
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Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,et al. SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae[J]. FEMS YEAST RESEARCH,2011,11(4):345-355.
APA Guo, Zhenhua,Adomas, Aleksandra B.,Jackson, Erin D.,Qin, Hong,&Townsend, Jeffrey P..(2011).SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae.FEMS YEAST RESEARCH,11(4),345-355.
MLA Guo, Zhenhua,et al."SIR2 and other genes are abundantly expressed in long-lived natural segregants for replicative aging of the budding yeast Saccharomyces cerevisiae".FEMS YEAST RESEARCH 11.4(2011):345-355.
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