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抗癌先导化合物S-3 的衍生物合成及构效关系研究 学位论文
, 北京: 中国科学院大学, 2014
作者:  晏晨
Adobe PDF(6909Kb)  |  收藏  |  浏览/下载：138/14  |  提交时间：2016/05/31
S-3  Wnt 信号通路抑制剂  Αβ-不饱和酮  Bax /bak 双缺失细胞株  抗肿瘤  
Spiramine derivatives induce apoptosis of Bax(-/-)/Bak(-/-) cell and cancer cells 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 卷号: 24, 期号: 8, 页码: 1884-1888
作者:  Yan, Chen;  Huang, Li;  Liu, Hong-Chun;  Chen, Duo-Zhi;  Liu, Hai-Yang;  Li, Xiao-Hui;  Zhang, Yu;  Geng, Mei-Yu;  Chen, Quan;  Hao, Xiao-Jiang
Adobe PDF(1562Kb)  |  收藏  |  浏览/下载：270/41  |  提交时间：2014/06/23
Spiramine Derivative  Bax(-/-)/bak(-/-) Cells  Alpha  Apoptosis  Beta-unsaturated Ketone  Cytotoxicity  
Cordycepol C Induces Caspase-Independent Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells 期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2014, 卷号: 37, 期号: 4, 页码: 608-617
作者:  Sun, Yi-sheng;  Lv, Long-xian;  Zhao, Zhao;  He, Xian;  You, Lu;  Liu, Ji-kai;  Li, Yong-quan
Adobe PDF(3093Kb)  |  收藏  |  浏览/下载：215/53  |  提交时间：2014/05/16
Cordycepol c  Apoptosis  Bax Protein  Apoptosis-inducing Factor  Endonuclease g  
Transcriptome-Wide Mapping of Pea Seed Ageing Reveals a Pivotal Role for Genes Related to Oxidative Stress and Programmed Cell Death 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 10
作者:  Chen, Hongying;  Osuna, Daniel;  Colville, Louise;  Lorenzo, Oscar;  Graeber, Kai;  Kuester, Helge;  Leubner-Metzger, Gerhard;  Kranner, Ilse
Adobe PDF(2073Kb)  |  收藏  |  浏览/下载：473/60  |  提交时间：2014/01/13
Protein S-glutathionylation  Signal-regulating Kinase-1  Arabidopsis-thaliana  Bax Inhibitor-1  Differential Expression  Lipid-peroxidation  Induced Apoptosis  Messenger-rna  Nicotiana-benthamiana  Microarray Analysis  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：214/42  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
毛萼乙素诱导肝细胞癌细胞凋亡的实验研究 期刊论文
热带医学杂志, 2013, 期号: 5, 页码: 535-537，520
白海燕; 谢丹; 廖奕佶; 买世娟; 阳桂香; 普建新; 李朝晖
Adobe PDF(468Kb)  |  收藏  |  浏览/下载：203/56  |  提交时间：2014/04/09
毛萼乙素  肝癌  细胞凋亡  Bax  Parp  
A new anticancer compound, Oblongifolin C, inhibits tumor growth and promotes apoptosis in HeLa cells through bax activation 期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2012, 卷号: 131, 期号: 6, 页码: 1445-1454
作者:  Feng, Chao;  Zhou, Li-Ying;  Yu, Ting;  Xu, Gang;  Tian, Hong-Lei;  Xu, Jin-Jie;  Xu, Hong-Xi;  Luo, Kathy Qian
Adobe PDF(1707Kb)  |  收藏  |  浏览/下载：323/86  |  提交时间：2012/11/30
Anticancer Drug Discovery  Herbal Medicine  Oblongifolin c  Apoptosis  Bax