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New Labdane diterpenes from Hedychium yunnanense with cytotoxicity and inhibitory effects on nitric oxide production 期刊论文
NATURAL PRODUCT RESEARCH, 2016, 卷号: 30, 期号: 23, 页码: 2669-2674
作者:  Li, Yu-Peng;  Zhao, Si-Meng;  Xu, Jun-Ju;  Zeng, Guang-Zhi;  Li, Yan;  Tan, Ning-Hua;  Yang, Ye
浏览  |  Adobe PDF(900Kb)  |  收藏  |  浏览/下载：217/46  |  提交时间：2017/01/05
Zingiberaceae  Hedychium Yunnanense  Labdane Diterpenes  Inhibition Of No Production  Cytotoxicity  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：211/42  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Rubiyunnanins A and B, two novel cyclic hexapeptides from Rubia yunnanensis 期刊论文
TETRAHEDRON LETTERS, 2010, 卷号: 51, 期号: 52, 页码: 6810-6813
作者:  Fan, Jun-Ting;  Chen, Yi-Shan;  Xu, Wen-Yan;  Du, Liangcheng;  Zeng, Guang-Zhi;  Zhang, Yu-Mei;  Su, Jia;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(444Kb)  |  收藏  |  浏览/下载：338/128  |  提交时间：2012/03/21
Rubia Yunnanensis  Rubiyunnanin a  Rubiyunnanin b  Cyclopeptides  Cytotoxicity  Inhibition Of No Production  
Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-kappa B activation 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2010, 卷号: 18, 期号: 23, 页码: 8226-8234
作者:  Fan, Jun-Ting;  Su, Jia;  Peng, Yan-Min;  Li, Yan;  Li, Jia;  Zhou, Yu-Bo;  Zeng, Guang-Zhi;  Yan, He;  Tan, Ning-Hua
Adobe PDF(424Kb)  |  收藏  |  浏览/下载：370/161  |  提交时间：2012/03/21
Rubia Yunnanensis  Rubiyunnanins C-h  Cyclopeptides  Cytotoxicity  Inhibition Of No Production  Nf-kappa b Pathway Inhibitors