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An efficient and concise synthesis of a selective small molecule non-peptide inhibitor of cathepsin L: KGP94 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105317
作者:  Munikishore,Rachakunta;  Wang,Liang-Liang;  Zhang,Shuqun;  Zhao,Qin-Shi;  Zuo,Zhili
Adobe PDF(523Kb)  |  收藏  |  浏览/下载：55/14  |  提交时间：2022/04/02
Cathepsin L  small-molecule inhibitor  gram-scale synthesis  KGP94  cancer  FUNCTIONALIZED BENZOPHENONE  BIOLOGICAL EVALUATION  TUMOR PROGRESSION  CELL INVASION  EXPRESSION  ANALOGS  SUPPRESSION  DERIVATIVES  ACID  
Discovery of novel inhibitors against main protease (Mpro) of SARS-CoV-2 via virtual screening and biochemical evaluation 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 110, 页码: 104767
作者:  Guo,Sheng;  Xie,Hang;  Lei,Yu;  Liu,Bin;  Zhang,Li;  Xu,Yechun;  Zuo,Zhili
Adobe PDF(3181Kb)  |  收藏  |  浏览/下载：64/28  |  提交时间：2022/04/02
SARS-CoV-2  Main protease  Virtual screening  Biochemical evaluation  
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis 期刊论文
PHARMACOLOGICAL RESEARCH, 2021, 卷号: 166, 页码: 105527
作者:  Zhou,Lutan;  Yin,Ronghua;  Gao,Na;  Sun,Huifang;  Chen,Dingyuan;  Cai,Ying;  Ren,Lin;  Yang,Lian;  Zuo,Zhili;  Zhang,Hongbin;  Zhao,Jinhua
浏览  |  Adobe PDF(8336Kb)  |  收藏  |  浏览/下载：61/10  |  提交时间：2022/04/02
Oligosaccharides  Heparanase  Angiogenesis  Metastasis  FIBROBLAST-GROWTH-FACTOR  TUMOR-GROWTH  SULFATE PROTEOGLYCANS  MAMMALIAN HEPARANASE  COMBINATION  MECHANISMS  DISCOVERY  BINDING  TARGET  PI-88  
Discovery of novel modulators targeting human TRPC5: Docking-based virtual screening, molecular dynamics simulation and binding af fi nity predication 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 102, 页码: 107795
作者:  Liu,Bin;  Zhang,Wei;  Guo,Sheng;  Zuo,Zhili
浏览  |  Adobe PDF(4277Kb)  |  收藏  |  浏览/下载：57/10  |  提交时间：2022/04/02
hTRPC5  Homology modeling  Molecular docking  Molecular dynamics simulation  Virtual screening  INHIBITOR  CHANNELS  GROMACS  POTENT  AMBER  IDENTIFICATION  CONSTRAINTS  INTEGRATION  AMYGDALA  
Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor 期刊论文
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2021, 卷号: 105, 页码: 107893
作者:  Guo,Sheng;  Yang,Jing;  Lei,Yu;  Liu,Bin;  Zhang,Wei;  Zhang,Li;  Zuo,Zhili
浏览  |  Adobe PDF(3681Kb)  |  收藏  |  浏览/下载：58/11  |  提交时间：2022/04/02
SARS-CoV-2  COVID-19  Homology modeling  Molecular dynamics simulation  Binding free energy  CORONAVIRUS SPIKE PROTEIN  ACTIVATION  GROMACS  ENTRY  
Unveiling the Disaccharide-Branched Glycosaminoglycan and Anticoagulant Potential of Its Derivatives 期刊论文
BIOMACROMOLECULES, 2021, 卷号: 22, 期号: 3, 页码: 1244-1255
作者:  Yin,Ronghua;  Zhou,Lutan;  Gao,Na;  Lin,Lisha;  Sun,Huifang;  Chen,Dingyuan;  Cai,Ying;  Zuo,Zhili;  Hu,Kaifeng;  Huang,Shengxiong;  Liu,Jikai;  Zhao,Jinhua
浏览  |  Adobe PDF(4401Kb)  |  收藏  |  浏览/下载：86/24  |  提交时间：2022/04/02
FUCOSYLATED CHONDROITIN SULFATE  DEPOLYMERIZED HOLOTHURIAN GLYCOSAMINOGLYCAN  INTRINSIC TENASE COMPLEX  SEA-CUCUMBER  FUCOSE BRANCHES  BODY-WALL  INDEPENDENT INHIBITION  POLYSACCHARIDE ACCOUNT  FACTOR XASE  HEPARIN  
Identification of Novel TRPC5 Inhibitors by Pharmacophore-Based and Structure-Based Approaches 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020
作者:  Li, Shuxiang;  Zhang, Shuqun;  Chen, Dingyuan;  Jiang, Xuan;  Liu, Bin;  Zhang, Hongbin;  Rachakunta, Munikishore;  Zuo, Zhili
浏览  |  Adobe PDF(4261Kb)  |  收藏  |  浏览/下载：100/31  |  提交时间：2021/01/05
Computational simulation studies on the binding selectivity of Wee1 and Checkpoint kinase 1 by molecular dynamics simulation combined with free energy calculations 期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020
作者:  Li, Yaping;  Liu, Xingyong;  Zhang, Shuqun;  Wang, Liangliang;  Zhang, Li;  Zuo, Zhili
浏览  |  Adobe PDF(2066Kb)  |  收藏  |  浏览/下载：106/17  |  提交时间：2021/01/05
NMR characterization and anticoagulant activity of the oligosaccharides from the fucosylated glycosaminoglycan isolated from Holothuria coluber 期刊论文
CARBOHYDRATE POLYMERS, 2020
作者:  Yang, Wenjiao;  Chen, Dingyuan;  He, Zhicheng;  Zhou, Lutan;  Cai, Ying;  Mao, Hui;  Gao, Na;  Zuo, Zhili;  Yin, Ronghua;  Zhao, Jinhua
浏览  |  Adobe PDF(2127Kb)  |  收藏  |  浏览/下载：137/66  |  提交时间：2021/01/05
Discovery of highly functionalized 5,6-seco-grayanane diterpenoids as potent competitive PTP1B inhibitors 期刊论文
ORGANIC CHEMISTRY FRONTIERS, 2020
作者:  Zhou, Junfei;  Zuo, Zhili;  Liu, Junjun;  Zhang, Hanqi;  Zheng, Guijuan;  Yao, Guangmin
浏览  |  Adobe PDF(1539Kb)  |  收藏  |  浏览/下载：102/21  |  提交时间：2021/01/05