中国科学院昆明植物研究所知识管理系统(KIB OpenIR): 检索

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资助项目：The chemical constituents of eight higher fungi and one medicinal plant were investigated. The fungi included Trametes corrugate, Campanella junghuhnii, Craterellus cornucopioides, Phlebia radiate, Laccaria amethystea, Hydnochaete sp., Nidula sp. and Rhodophyllus ater, which are all collected from Yunnan province, P. R. China. The leaves of Cynara scolymus L. (Artichoke) were collected from south of Vietnam. 119 compounds, including 91 different compounds and 9 new ones, have been obtained using varied chromatographic methods, and the structures of new metabolites were elucidated on the basis of extensive spectroscopic analysis including IR, UV, MS, 1D- and 2D-NMR experiments.Two unusual diterpenes (13-14) with neodolastane skeletons were isolated and identified from the culture broth of Trametes corrugate. This type of diterpene was obtained for the first time from higer fungi. A new tricyclo[6.3.1.02,5]dodecane sesquiterpene (1) was isolated from the culture broth of Campanella junghuhnii. Three new keto esters (65-67) and a series of illudine sesquiterpenes (4-10) were isolated and identified from the culture broth of the basidiomycete Craterellus cornucopioides. A new fatty acid ester (48) was isolated from the culture broth of Phlebia radiate.A new isoprenyl phenyl ether riboside (68) was isolated from culture broth of Laccaria amethystea. During our studies on chemical constituents of the culture broth of Hydnochaete sp., a conjugate lactone (71) was obtained. Preliminary biological assay showed that the lactone exhibited inhibitory activity against the11b-hydroxysteroid dehydrogenase (11β-HSD1) of human and mouse with IC50 value of 53.338 mg/mL and 95.950 mg/mL, respectively. A new guaiane-type sesquiterpene lactone (2) and a new phenolic glucoside gallate (69) were isolated and identified from the leaves of Cynara scolymus (Artichoke). A review summarized their structures, biological activities, and the producing species of naturally occurring triterpenes from higher fungi. The paper provides 433 structurally diverse compounds published between 1985~2010, and 114 references

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