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Nematicidal quinone derivatives from three & IT;Rubia & IT; plants 期刊论文
TETRAHEDRON, 2018, 卷号: 74, 期号: 17, 页码: 2115-2120
作者:  Zhao, Si-Meng;  Kuang, Bin;  Zeng, Guang-Zhi;  Wang, Zhe;  Wang, Jia;  Chen, Xiao-Qiang;  Tan, Ning-Hua
浏览  |  Adobe PDF(696Kb)  |  收藏  |  浏览/下载：194/30  |  提交时间：2018/05/31
Rubia  Rubia Alata  Rubia Wallichiana  Rubia Schumanniana  Quinones  Nematicidal Activity  
1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans10.3390/molecules22050798 期刊论文
MOLECULES, 2017, 卷号: 22, 期号: 5, 页码: 798
作者:  Wang, Jia;  Zeng, Guangzhi;  Huang, Xiaobing;  Wang, Zhe;  Tan, Ninghua
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Plant-parasitic Nematode  Phytochemical  Nematocidal  Oxidative Stress  1  Insulin/igf Signaling Pathway  4-naphthoquinone  Caenorhabditis Elegans  
醌类化合物及其制备方法与其用作为杀线虫农药 专利
专利类型: 发明, 专利号: CN201410736175.9, 申请日期: 2014-12-05, 公开日期: 2015-03-25
发明人:  谭宁华;  曾广智;  赵思蒙;  王佳
Adobe PDF(749Kb)  |  收藏  |  浏览/下载：255/7  |  提交时间：2016/12/19
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
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One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.