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常用中药紫菀和王不留行的环肽和其他成分及其生物活性研究 学位论文
, 北京: 中国科学院大学, 2013
作者:  徐会敏
Adobe PDF(14311Kb)  |  收藏  |  浏览/下载：257/9  |  提交时间：2016/05/31
紫菀  王不留行  环肽王不留行  环肽  三萜皂苷  黄酮环肽全合成  免疫抑制活性和作用机制  
Processing and chemical constituents of Pu-erh tea: A review 期刊论文
FOOD RESEARCH INTERNATIONAL, 2013, 卷号: 53, 期号: 2, 页码: 608-618
作者:  Lv, Hai-peng;  Zhang, Ying-jun;  Lin, Zhi;  Liang, Yue-rong
Adobe PDF(1642Kb)  |  收藏  |  浏览/下载：1758/538  |  提交时间：2013/11/12
Pu-erh Tea  Chemical Constituents  Processing  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：209/42  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.  
Plant cyclopeptide RA-V kills human breast cancer cells by inducing mitochondria-mediated apoptosis through blocking PDK1-AKT interaction 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 卷号: 267, 期号: 1, 页码: 95-103
作者:  Fang, Xian-Ying;  Chen, Wei;  Fan, Jun-Ting;  Song, Ran;  Wang, Lu;  Gu, Yan-Hong;  Zeng, Guang-Zhi;  Shen, Yan;  Wu, Xue-Feng;  Tan, Ning-Hua;  Xu, Qiang;  Sun, Yang
浏览  |  Adobe PDF(1855Kb)  |  收藏  |  浏览/下载：719/122  |  提交时间：2013/03/18
Ra-v  Cyclopeptide  Mitochondrial Apoptosis Pathway  Pi3k/akt  Breast Cancer  
Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 59, 页码: 243-252
作者:  Yue, Grace G. L.;  Chan, Ben C. L.;  Kwok, Hin-Fai;  Wong, Yuk-Lau;  Leung, Hoi-Wing;  Ji, Chang-Jiu;  Fung, Kwok-Pui;  Leung, Ping-Chung;  Tan, Ning-Hua;  Lau, Clara B. S.
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Bigelovin  Inula Helianthus-aquatica  Angiogenesis  Zebrafish  Hmec-1  Cell Adhesion Molecules