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黄皮中的环肽和其它成分及其活性研究 学位论文
, 北京: 中国科学院大学, 2013
作者:  宋卫武
Adobe PDF(8403Kb)  |  收藏  |  浏览/下载：284/13  |  提交时间：2016/05/31
芸香科  黄皮  环肽  咔唑生物碱  香豆素  抗肿瘤  构效关系  作用机制  
Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.0(2,11)]undecane-Bridged System from Schisandra lancifolia 期刊论文
ORGANIC LETTERS, 2013, 卷号: 15, 期号: 19, 页码: 5068-5071
作者:  Shi, Yi-Ming;  Wang, Xin-Bo;  Li, Xiao-Nian;  Luo, Xiao;  Shen, Zi-Ying;  Wang, Yi-Ping;  Xiao, Wei-Lie;  Sun, Han-Dong
Adobe PDF(308Kb)  |  收藏  |  浏览/下载：264/70  |  提交时间：2014/01/13
Diastereoselective Total-synthesis  Lancifodilactone-g  (+/-)-schindilactone  Arisanensis  Fruits  
Phenolic constituents from Parakmeria yunnanensis and their anti-HIV-1 activity 期刊论文
ARCHIVES OF PHARMACAL RESEARCH, 2013, 卷号: 36, 期号: 10, 页码: 1223-1230
作者:  Shang, Shan-Zhai;  Chen, Huan;  Liang, Cheng-Qin;  Gao, Zhong-Hua;  Du, Xue;  Wang, Rui-Rui;  Shi, Yi-Ming;  Zheng, Yong-Tang;  Xiao, Wei-Lie;  Sun, Han-Dong
Adobe PDF(360Kb)  |  收藏  |  浏览/下载：270/65  |  提交时间：2013/11/12
Parakmeria Yunnanensis  Yunnanensins A-c  Phenolic Constituents  Anti-hiv-1  
阿司匹林抗衰老机制 学位论文
, 北京: 中国科学院大学, 2013
作者:  万钦黎
Adobe PDF(2100Kb)  |  收藏  |  浏览/下载：235/9  |  提交时间：2016/05/31
阿司匹林  衰老  节食  秀丽隐杆线虫  
两种五味子科和两种木兰科植物的化学成分及其生物活性研究 学位论文
, 北京: 中国科学院大学, 2013
作者:  尚善斋
Adobe PDF(4398Kb)  |  收藏  |  浏览/下载：129/7  |  提交时间：2016/05/31
日本南五味子  铁箍散  红花木莲  云南拟单性木兰  化学成分  生物活性  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
浏览  |  Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：211/42  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.