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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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资助项目:In order to investigate the bio-diversity of chemical constituents in Cimicifuga foetida L. from Southwest China, to explore the constituents with anti-cancer activity in Traditional Chinese Medicine Cimicifugae Rhizomes, we analyzed the chemical constiturents from the rhizomes of C. foetida L. collected from Sichuan, Guizhou and Yunnan. The in vitro and in vivo test were also carried out. We will discuss about the research thoroughly in this Ph. D. dissertation. The dissertation contains three chapters. The phytochemical studies of four Cimicifuga foetida L. from different habitat in Southwest China are discussed in Chapter 1-The Chemical Constituents of Cimicifuga foetida L. from Different Habitat in Southwest China. The separation and identification of 57 compounds including 22 new ones from C. foetida L.were written in detail. Among the new compounds, there are 20 triterpenoids, most of which are cycloartane type, one 2-quinolone based compound and a chrome glycoside. A series of triterpenen bisglycosides with free side chain were isolated from the n-BuOH portion of Cimicifuga foetida L. from Lijiang, which haven’t had any report in this genus before. Chapter 2-Inhibitory Effect of Constituents in Cimicifuga foetida L. on Cancer deals with the results of anti-cancer assay of compounds from Cimicifuga foetida L., most of which are new compounds. The results indicated the compounds with cytotoxicity focalized in a part with paticular polarity. Besides, inhibitory effect of two main constituents of C. foetida L., Actein and 23-epi-26-deoxyactein, on immunodeficiency nu/nu mice carrying human breast cancer BCap-37 tumers were studied. Their inhibitory effects were even stronger than the positive control tamoxifen [Tumor Inhibitory rate (%):57.7 (A: 9 mg/kg) & 54.8 (DA: 27 mg/kg) vs 33.6 (TAM: 2 mg/kg)].Chapter 3-Review of pharmacological studies on Cimicifuga and its constituents in the decade is an review of pharmacological studies about extracts and compounds in Cimicifuga genus in the decade. There are reports of activities of anticancer, menopausal syndrome amelioration, antiosteoporosis, anti-inflammatory, immunosupression on extracts, triterpenoids, cinnamic derivatives and a 5-HT derivative of Cimicifuga genus. The results indicated that the major triterpenoids constituents in C. foetida L. is stable, especially the triterpenoids with the midium polarity, whereas the compounds yielded from the small and large polarity change due to the different habitat. Fortunately, the anti-cancer triterpenoids assemble in the stable midium polarity part. We can extract them for the better treatment in the future