中国科学院昆明植物研究所知识管理系统(KIB OpenIR): Search Results

Collection

昆明植物所硕博研究生... [1]

Authors

Document Type

Thesis [1]

Date Issued

2010 [1]

Language

Source Publication

Funding Project

Indexed By

Funding Organization

KIB OpenIR

Browse/Search Results: 1-1 of 1

Help

Filters

Funding Project：This thesis elaborated the studies on the alkaloids from three Daphniphyllum species, the leaves and twigs of Daphniphyllum himalense (Benth.) Mull.-Arg., Daphniphyllum paxianum Rosenth., and Daphniphyllum oldhami Rosenth. along with alkaloids from root-stems of Lycoris radiate. Seventy-nine alkaloids were acquired totally from those four plants by variety of chromatographies over various materials, and their structures were identified by spectroscopic data analysis. Among them, sixteen Daphniphyllum alkaloids were new ones, including two novel ones with unprecedented skeleton.Chapter 1 Alkaloids from Daphniphyllum himalense (Benth.) Mull.-Arg.Twenty-four alkaloids, including seven new Daphniphyllum alkaloids were isolated and elucidated from the leaves of D. himalense (Benth.) Mull.-Arg. Among the seven new alkaloids, compound 1 (daphhimalenine A) was a novel one with rearranged skeleton. Biogenetically, compound 1 may originated from the two yuzurimine-type alkaloids, 2 (daphhimalenine B) and 3 (daphnezomine T), which were also isolated from the same plants. Seven alkaloids were also isolated and identified from the twigs of D. himalense (Benth.) Mull.-Arg.Chapter 2 Alkaloids from Daphniphyllum paxianum Rosenth.Investigation of alkaloid constituents of the leaves and twigs of Daphniphyllum paxianum Rosenth. has resulted in the isolation of seventeen alkaloids. And five were new ones. Among them, compound 1 (paxiphylline A) was a novel Daphniphyllum alkaloid with an unprecedented additional carbon daphnicyclidin skeleton. From a biogenetic perspective, the “extra” carbon unit may be provided by formaldehyde through aldol condensation.Chapter 3 Alkaloids from Daphniphyllum oldhami Rosenth.In this work, twelve alkaloids, including four new ones, were isolated and elucidated from the leaves of Daphniphyllum oldhami Rosenth. Among them, compound 2 (dapholdhamine B) was the third daphnezomine types of Daphniphyllum alkaloid till now.Chapter 4 Alkaloids from Lycoris radiate.Nineteen alkaloids were isolated and elucidated from rough alkaloids of the root-stems of Lycoris radiate, which was bought from Guangde Bio-tech Ltd of Kunming. The inhibition activities against HBV of these alkaloids were evaluated which indicated that some subclass of benzylphenethylamine alkaloids has high inhibition activities against DNA replication of HBV. Meanwhile, structural modification of several types of benzylphenethylamine alkaloids were in progress.Chapter 5 Review.Advances research of Mannich-like reactions in terpenoids alkaloids, including monoterpenoid indole alkaloids as the “true alkaloids”, diterpenoid alkaloids as the “pseudo alkaloids”, and the Daphniphyllum alkaloids as the “unusal alkaloids” from biosynthetic and total synthesis point of view was reviewed.

中国科学院昆明植物研究所知识管理系统

Search in the results