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Design, synthesis and structure-activity relationship optimization of phenanthridine derivatives as new Wnt/beta-catenin signalling pathway agonists 期刊论文
BIOORGANIC CHEMISTRY, 2019, 卷号: 84, 页码: 285-294
Authors:  Chen, Duo-zhi;  Yang, Bi-juan;  He, Xiao-li;  Fan, Shi-rui;  Cai, Jie-yun;  Jing, Chen-xu;  Zhang, Heng;  Zhang, Yu;  Li, Lin;  Hao, Xiao-jiang
Favorite  |  View/Download:106/0  |  Submit date:2019/03/18
Wnt/beta-catenin signalling pathway agonist  Phenanthridine derivatives  Structural optimization  Structure-activity relationships (SARs)  
Efficient synthesis of new phenanthridine Wnt/beta-catenin signaling pathway agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 1491-1499
Authors:  Chen, Duozhi;  Zhang, Heng;  Jing, Chenxu;  He, Xiaoli;  Yang, Bijuan;  Cai, Jieyun;  Zhou, Yunfu;  Song, Xiaoming;  Li, Lin;  Hao, Xiaojiang
Favorite  |  View/Download:297/0  |  Submit date:2018/11/12
Wnt/beta-catenin signaling agonist  Phenanthridine derivatives  Structural optimization  
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
Authors:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
View  |  Adobe PDF(1966Kb)  |  Favorite  |  View/Download:75/32  |  Submit date:2019/03/27
Natural and Semisynthetic Tigliane Diterpenoids with New Carbon Skeletons from Euphorbia dracunculoides as a Wnt Signaling Pathway Inhibitor 期刊论文
ORGANIC LETTERS, 2017, 卷号: 19, 期号: 14, 页码: 3911-3914
Authors:  Wang, Li;  Yang, Jing;  Kong, Ling-Mei;  Deng, Jun;  Xiong, Zijun;  Huang, Jianping;  Luo, Jianping;  Yan, Yijun;  Hu, Yikao;  Li, Xiao-Nian;  Li, Yan;  Zhao, Yong;  Huang, Sheng-Xiong
View  |  Adobe PDF(1338Kb)  |  Favorite  |  View/Download:133/37  |  Submit date:2017/10/23
Protein-kinase-c  Phorbol Esters  Biological Evaluation  Biosynthesis  (+)-phorbol  Analogs  Cancer  Seeds  
GLA 靶向Wnt 信号通路抑制结直肠肿瘤的研究 学位论文
: 中国科学院大学, 2017
Authors:  龚雅潇
Adobe PDF(6597Kb)  |  Favorite  |  View/Download:26/6  |  Submit date:2019/06/14
USP7 作为结直肠肿瘤治疗靶点的研究 学位论文
: 中国科学院大学, 2017
Authors:  安涛
Adobe PDF(4516Kb)  |  Favorite  |  View/Download:25/4  |  Submit date:2019/06/14
USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2017, 卷号: 131, 期号: 1, 页码: 29-39
Authors:  An, Tao;  Gong, Yaxiao;  Li, Xue;  Kong, Lingmei;  Ma, Pengcheng;  Gong, Liang;  Zhu, Huifang;  Yu, Chunlei;  Liu, Jianmei;  Zhou, Hongyu;  Mao, Bingyu;  Li, Yan
View  |  Adobe PDF(3138Kb)  |  Favorite  |  View/Download:640/105  |  Submit date:2017/04/06
Usp7 Inhibitor  Wnt Signaling  Colorectal Cancer  
Rapid synthesis of ismine, a bioactive amaryllidaceae alkaloid 期刊论文
JOURNAL OF CHEMICAL RESEARCH, 2017, 期号: 4, 页码: 202-204
Authors:  Guo, Jing-jing;  Yang, Bi-juan;  Jing, Chen-xu;  Chen, Duo-zhi;  Hao, Xiao-jiang
View  |  Adobe PDF(192Kb)  |  Favorite  |  View/Download:36/2  |  Submit date:2018/05/08
Amaryllidaceae Alkaloid  Palladium Catalyst  Aryl-aryl Coupling  N-aryl Coupling  
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
Authors:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
View  |  Adobe PDF(3775Kb)  |  Favorite  |  View/Download:49/3  |  Submit date:2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
Z86 靶向肿瘤干细胞及Star-PAP 抑制乳腺癌的机制研究 学位论文
: 中国科学院大学, 2016
Authors:  于春雷
Adobe PDF(11449Kb)  |  Favorite  |  View/Download:18/4  |  Submit date:2019/06/14