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B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：220/27  |  提交时间：2019/06/24
Discovery of new dual binding TNKS inhibitors of Wnt signaling inhibition by pharmacophore modeling, molecular docking and bioassay 期刊论文
MOLECULAR BIOSYSTEMS, 2017, 卷号: 13, 期号: 2, 页码: 363-370
作者:  Pu, Yinglan;  Zhang, Shuqun;  Chang, Zhe;  Zhang, Yunqin;  Wang, Dong;  Zhang, Li;  Li, Yan;  Zuo, Zhili
浏览  |  Adobe PDF(972Kb)  |  收藏  |  浏览/下载：653/115  |  提交时间：2017/05/19
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
作者:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
浏览  |  Adobe PDF(1734Kb)  |  收藏  |  浏览/下载：162/29  |  提交时间：2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
Design, Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4 beta-Triazolopodophyllotoxin Derivatives 期刊论文
MOLECULES, 2015, 卷号: 20, 期号: 2, 页码: 3255-3280
作者:  Zi, Cheng-Ting;  Liu, Zhen-Hua;  Li, Gen-Tao;  Li, Yan;  Zhou, Jun;  Ding, Zhong-Tao;  Hu, Jiang-Miao;  Jiang, Zi-Hua;  Ding,ZT (reprint author),Yunnan Univ,Key Lab Med Chem Nat Resource,Minist Educ,Sch Chem Sci & Technol,Kunming 650091,Peoples R China.;  zict@sina.cn;  liuzhenhua@mail.kib.ac.cn;  ligentao@mail.kib.ac.cn;  liyanb@mail.kib.ac.cn;  jzhou@mail.kib.ac.cn;  ztding@ynu.edu.cn;  hujiangmiao@mail.kib.ac.cn;  zjiang@lakeheadu.ca
浏览  |  Adobe PDF(910Kb)  |  收藏  |  浏览/下载：239/56  |  提交时间：2015/06/29
New alkaloids sinomacutines A-E, and cephalonine-2-O-beta-D-glucopyranoside from rhizomes of Sinomenium acutum 期刊论文
TETRAHEDRON, 2014, 卷号: 70, 期号: 46, 页码: 8893-8899
作者:  Li, Yan-Hong;  Li, Hong-Mei;  Li, Yan;  He, Juan;  Deng, Xu;  Peng, Li-Yan;  Gao, Ling-Huan;  Zhao, Qin-Shi;  Li, Rong-Tao;  Wu, Xing-De;  Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Kunming 650500,Yunnan,Peoples R China.;  rongtaolikm@gmail.com;  wuxingde@mail.kib.ac.cn
浏览  |  Adobe PDF(673Kb)  |  收藏  |  浏览/下载：232/65  |  提交时间：2015/01/20
Sinomenium Acutum  Bistetrahydroisoquinoline Alkaloid  Acid Hydrolysis  Cytotoxicity  Anti-inflammatory Activity  
Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 20, 页码: 10140-10150
作者:  Zhou, Hongyu;  Shen, Tao;  Shang, Chaowei;  Luo, Yan;  Liu, Lei;  Yan, Juming;  Li, Yan;  Huang, Shile
浏览  |  Adobe PDF(2703Kb)  |  收藏  |  浏览/下载：185/41  |  提交时间：2015/06/17
Ciclopirox  Autophagy  Rhabdomyosarcoma  Reactive Oxygen Species  Jnk  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：656/97  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：286/59  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol