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Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 11
作者:  Liu, Tangjingjun;  Xia, Lei;  Yao, Yao;  Yan, Chen;  Fan, Yanhua;  Gajendran, Babu;  Yang, Jue;  Li, You-Jun;  Chen, Juan;  Filmus, Jorge;  Spaner, David E.;  Zacksenhaus, Eldad;  Hao, Xiaojiang;  Ben-David, Yaacov
浏览  |  Adobe PDF(2055Kb)  |  收藏  |  浏览/下载:287/42  |  提交时间:2019/04/15
Efficient synthesis of new phenanthridine Wnt/b-catenin signaling pathway agonists 期刊论文
European Journal of Medicinal Chemistry, 2018, 卷号: 157, 页码: 1491-1499
作者:  Duozhi Chen;  Heng Zhang;  Chenxu Jing;  Xiaoli He;  Bijuan Yang;  Jieyun Cai;  Yunfu Zhou;  Xiaoming Song;  Lin Li;  Xiaojiang Hao
浏览  |  Adobe PDF(1966Kb)  |  收藏  |  浏览/下载:243/101  |  提交时间:2019/03/27
Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A 期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7, 页码: 1
作者:  Yuan, Wen-Juan;  Ding, Xiao;  Wang, Zhe;  Yang, Bi-Juan;  Li, Xiao-Nian;  Zhang, Yu;  Chen, Duo-Zhi;  Li, Shun-Lin;  Chen, Quan;  Di, Ying-Tong;  Aisa, Haji Akber;  Hao, Xiao-Jiang
浏览  |  Adobe PDF(3375Kb)  |  收藏  |  浏览/下载:304/59  |  提交时间:2017/12/18
Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/beta-catenin transcriptional activity 期刊论文
CELL DISCOVERY, 2017, 卷号: 3, 页码: 17003
作者:  He, Xiaoli;  Zhang, Wenjuan;  Yan, Chen;  Nie, Fen;  Li, Chen;  Liu, Xiaofen;  Fei, Cong;  Li, Shengdi;  Song, Xiaomin;  Jia, Yingying;  Zeng, Rong;  Wu, Dianqing;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(3775Kb)  |  收藏  |  浏览/下载:166/43  |  提交时间:2017/12/18
Carf  Chemical Biology  Nc043  Small Molecule  Wnt Signaling  
A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis 期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2013, 卷号: 63, 期号: SI, 页码: 485-494
作者:  Liu, Jinhua;  Mu, Chenglong;  Yue, Wen;  Li, Jie;  Ma, Biao;  Zhao, Lixia;  Liu, Lei;  Chen, Quan;  Yan, Chen;  Liu, Haiyang;  Hao, Xiaojiang;  Zhu, Yushan
浏览  |  Adobe PDF(2679Kb)  |  收藏  |  浏览/下载:323/61  |  提交时间:2013/10/16
Thioredoxin Reductase  Bim  Ros  Apoptosis  Cancer  
Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction 期刊论文
NATURE CHEMICAL BIOLOGY, 2013, 卷号: 9, 期号: 9, 页码: 579-U82
作者:  Wang, Sheng;  Yin, Junlin;  Chen, Duozhi;  Nie, Fen;  Song, Xiaomin;  Fei, Cong;  Miao, Haofei;  Jing, Changbin;  Ma, Wenjing;  Wang, Lei;  Xie, Sichun;  Li, Chen;  Zeng, Rong;  Pan, Weijun;  Hao, Xiaojiang;  Li, Lin
浏览  |  Adobe PDF(1157Kb)  |  收藏  |  浏览/下载:642/133  |  提交时间:2013/10/16
Glycogen-synthase Kinase-3  Beta-catenin  Negative Regulator  Dix Domain  Stem-cells  In-vivo  Axin  Activation  Pathway  Phosphorylation