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中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
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6 could use lots of photosynthates, but contributed little to the accumulation of biomass. 4. Photosynthetic rate of P. armeniacum decreased a little at the noon, and the highest photosynthetic rate was observed at 10:00h in the greenhouse. The variation of photosynthetic rate was in the same trend as stomatal conductance. Higher relative humidity seemed to be the key for higher photosynthetic rate in P. armeniacum. 5. The photosynthetic capacity of C. flavum was statistically larger than that of P. armeniacum. The lower leaf photosynthetic capacity of P. armeniacum was related to its lower leaf nitrogen concentration,leaf phosphorus concentration and enzyme activities. Meanwhile, the extremely lower stomatal conductance and internal mesophyll conductance might greatly limit the photosynthetic capacity of P. armeniacum. The lower stomatal conductance and photosynthetic rate of Paphiopedilum might partially caused by the lack of chloroplasts in the guard cell of Paphiopedilum. Compared with C. flavum, P. armeniacum was more fond of shade environment.6. The short longevity leaf of Cypripedium had bigger photosynthetic capacity and greater potential for fast growth. But the longer LL of Paphiopedilum enhanced nutrient conservation which could compensate its lower photosynthetic capacity. The short longevity leaf of Cypripedium usually had higher photosynthetic rate per unit leaf mass and dark respiration rate, and photosynthetic capacity decreased fast with leaf age. However, for Paphiopedilum, the situation was the opposite. 7. Compared with Cypripedium, Paphiopedilum had higher water use efficiency and lower photosynthetic nitrogen use efficiency. 8. The leaf of Paphiopedilum had higher leaf construction cost and longer repayment time than that of Cypripedium. The leaf structures and physiological functions of Paphiopedilum and Cypripedium reflected the adaptation to their habitats. The leaf morphological and physiological evolution of Paphiopedilum was related to water and resource-conserving traits in the karst habitat. The leaf traits of Cypripedium were the adaptation to the environment rich in water and nutrients but easy to change with seasons.Our results provided evidence of divergent evolution of congeneric orchids under natural selection.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3APaphiopedilum%5C+and%5C+Cypripedium%5C+are%5C+close%5C+relatives%5C+belonging%5C+to%5C+the%5C+subfamily%5C+Cypripedioideae.%5C+However%2C%5C+they%5C+undergo%5C+considerable%5C+divergence%5C+in%5C+the%5C+aspects%5C+of%5C+life%5C+forms%2C%5C+leaf%5C+traits%5C+and%5C+habitats.%5C+In%5C+present%5C+study%2C%5C+leaf%5C+morphologies%5C+and%5C+anatomical%5C+structures%2C%5C+leaf%5C+lifespans%2C%5C+leaf%5C+mass%5C+per%5C+area%2C%5C+photosynthetic%5C+capacities%2C%5C+nutrient%5C+use%5C+efficiencies%2C%5C+leaf%5C+construction%5C+costs%2C%5C+and%5C+maintenance%5C+costs%5C+were%5C+investigated%5C+to%5C+understand%5C+the%5C+relationship%5C+between%5C+leaf%5C+traits%5C+and%5C+ecophysiological%5C+adaptability%5C+of%5C+the%5C+two%5C+types%5C+of%5C+plants%5C+and%5C+explore%5C+the%5C+related%5C+ecological%5C+and%5C+evolutionary%5C+significances.%5C+The%5C+results%5C+suggest%5C+that%5C%3A1.%5C+Compared%5C+with%5C+Cypripedium%2C%5C+Paphiopedilum%5C+was%5C+characterized%5C+by%5C+drought%5C+tolerance%5C+from%5C+its%5C+leaf%5C+anatomical%5C+structure%5C+including%5C+fleshy%5C+leaf%2C%5C+thicker%5C+surface%5C+cuticle%2C%5C+huge%5C+abaxial%5C+epidermis%5C+cells%2C%5C+differentiation%5C+of%5C+palisade%5C+and%5C+spongy%5C+mesophyll%5C+layers%2C%5C+the%5C+prominent%5C+of%5C+mucilaginous%5C+substances%2C%5C+supportable%5C+leaf%5C+main%5C+vein%2C%5C+lower%5C+total%5C+stoma%5C+area%5C+%5C%28%25%5C%29%2C%5C+sunken%5C+stomata%5C+and%5C+special%5C+stoma%5C+structure.%5C+Leaf%5C+morphologies%5C+and%5C+structures%5C+of%5C+Cypripedium%5C+were%5C+to%5C+the%5C+contrary%5C+of%5C+Paphiopedilum.%5C+Leaf%5C+morphologies%5C+and%5C+structures%5C+embodied%5C+the%5C+adaptation%5C+to%5C+the%5C+environment%5C+in%5C+both%5C+Paphiopedilum%5C+and%5C+Cypripedium.%5C+Our%5C+results%5C+also%5C+confirmed%5C+the%5C+previous%5C+observation%5C+that%5C+Paphiopedilum%5C+was%5C+the%5C+only%5C+genus%5C+that%5C+did%5C+not%5C+possess%5C+guard%5C+cell%5C+chloroplasts.2.%5C+The%5C+photosynthetic%5C+capacities%5C+of%5C+P.%5C+armeniacum%5C+leaves%5C+were%5C+different%5C+with%5C+different%5C+leaf%5C+ages.%5C+The%5C+highest%5C+photosynthetic%5C+capacity%5C+occurred%5C+in%5C+leaf%5C+age%5C+1%5C-2%5C+years%2C%5C+followed%5C+by%5C+1%5C+year%5C+and%5C+2%5C-4%5C+years.%5C+The%5C+highest%5C+photosynthetic%5C+capacity%5C+of%5C+C.%5C+flavum%5C+occurred%5C+in%5C+leaf%5C+age%5C+60%5C+days%2C%5C+followed%5C+by%5C+30%5C+days%2C%5C+90%5C+days%5C+and%5C+120%5C+days.%5C+3.%5C+Photosynthetic%5C+capacities%5C+of%5C+different%5C+leaf%5C+positions%5C+were%5C+mainly%5C+affected%5C+by%5C+leaf%5C+ages%5C+in%5C+P.%5C+armeniacum.%5C+The%5C+four%5C+leaves%5C+lying%5C+on%5C+the%5C+top%5C+did%5C+the%5C+most%5C+accumulation%5C+of%5C+the%5C+assimilation%5C+products%5C+in%5C+the%5C+whole%5C+plant.%5C+The%5C+leaves%5C+of%5C+sequence%5C+number%5C+%3E%5C+6%5C+could%5C+use%5C+lots%5C+of%5C+photosynthates%2C%5C+but%5C+contributed%5C+little%5C+to%5C+the%5C+accumulation%5C+of%5C+biomass.%5C+4.%5C+Photosynthetic%5C+rate%5C+of%5C+P.%5C+armeniacum%5C+decreased%5C+a%5C+little%5C+at%5C+the%5C+noon%2C%5C+and%5C+the%5C+highest%5C+photosynthetic%5C+rate%5C+was%5C+observed%5C+at%5C+10%5C%3A00h%5C+in%5C+the%5C+greenhouse.%5C+The%5C+variation%5C+of%5C+photosynthetic%5C+rate%5C+was%5C+in%5C+the%5C+same%5C+trend%5C+as%5C+stomatal%5C+conductance.%5C+Higher%5C+relative%5C+humidity%5C+seemed%5C+to%5C+be%5C+the%5C+key%5C+for%5C+higher%5C+photosynthetic%5C+rate%5C+in%5C+P.%5C+armeniacum.%5C+5.%5C+The%5C+photosynthetic%5C+capacity%5C+of%5C+C.%5C+flavum%5C+was%5C+statistically%5C+larger%5C+than%5C+that%5C+of%5C+P.%5C+armeniacum.%5C+The%5C+lower%5C+leaf%5C+photosynthetic%5C+capacity%5C+of%5C+P.%5C+armeniacum%5C+was%5C+related%5C+to%5C+its%5C+lower%5C+leaf%5C+nitrogen%5C+concentration%2Cleaf%5C+phosphorus%5C+concentration%5C+and%5C+enzyme%5C+activities.%5C+Meanwhile%2C%5C+the%5C+extremely%5C+lower%5C+stomatal%5C+conductance%5C+and%5C+internal%5C+mesophyll%5C+conductance%5C+might%5C+greatly%5C+limit%5C+the%5C+photosynthetic%5C+capacity%5C+of%5C+P.%5C+armeniacum.%5C+The%5C+lower%5C+stomatal%5C+conductance%5C+and%5C+photosynthetic%5C+rate%5C+of%5C+Paphiopedilum%5C+might%5C+partially%5C+caused%5C+by%5C+the%5C+lack%5C+of%5C+chloroplasts%5C+in%5C+the%5C+guard%5C+cell%5C+of%5C+Paphiopedilum.%5C+Compared%5C+with%5C+C.%5C+flavum%2C%5C+P.%5C+armeniacum%5C+was%5C+more%5C+fond%5C+of%5C+shade%5C+environment.6.%5C+The%5C+short%5C+longevity%5C+leaf%5C+of%5C+Cypripedium%5C+had%5C+bigger%5C+photosynthetic%5C+capacity%5C+and%5C+greater%5C+potential%5C+for%5C+fast%5C+growth.%5C+But%5C+the%5C+longer%5C+LL%5C+of%5C+Paphiopedilum%5C+enhanced%5C+nutrient%5C+conservation%5C+which%5C+could%5C+compensate%5C+its%5C+lower%5C+photosynthetic%5C+capacity.%5C+The%5C+short%5C+longevity%5C+leaf%5C+of%5C+Cypripedium%5C+usually%5C+had%5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secondary metabolites are a class of small molecular compounds which are not necessary for plant growth and development in nature. They have many types and different functions. The current studies about these compounds were often focused on the chemistry, pharmacology and drug development. Research about their biological effects is few. Exploration the biological effects of plant secondary metabolites is important to study their biological function and application. Scutellarin is an active pharmaceutical ingredient extracted from Erigeron breviscapus(vant) Hand Mass. It is an important plant secondary metabolite, belonging to flavonoid. Previous studies found that some flavonoids such as quercetin, naringenin were auxin transport inhibitors in plants and they were related to plant growth and development closely. As an important flavonoid, scutellarin also plays an important role in plant growth and development is unknown. In this paper, scutellarin was selected as research object. Through a series of plant physiological, biochemical and molecular techniques to explore the biological effects of scutellarin on Arabidopsis thaliana, we get the results as follows: Scutellarin had a hormone-like effect on Arabidopsis thaliana. It promoted root elongation at low concentration obviously; however the effect disappeared at high concentration. We made a further study about it and found that scutellarin had antagonism with methyl jasmonate and 2,4-dichlorophenoxy acetic acid (2,4-D) in root elongation. It also had an influence on nitrogen metabolism. Microarray results showed that the biological effects of scutellarin had a complex relationship with plant hormone and nitrogen metabolism. These were consistent with our experimental phenomenas. All these manifested that scutellarin played an important role in plant growth and development as a similar plant hormone. We tried the experiment using some other flavonoids. It was found that not all the flavonoids had the same obvious effects on root elongation like scutellarin; the biological effects of them were closely related to their chemical structures. In addition, the other two aspects of research were also carried out in the paper. One was exploring the role of phospholipase Dδ (PLDδ) under ultraviolet radiation in Arabidopsis. Our evidences suggested knockout PLDδ intensified membrane damage induced by UV radiation. The other one was lipid data collection and calculation of acyl chain lengths of lipid molecules in Arabidopsis under senescence induced by various stresses. We showed that the acyl chains of phosphoserine (PS, a head-group class of membrane glycerolipids with very long chains of fatty acids.) lengthened with the development and senescence in Arabidopsis. In contrast, the acyl chain lengths of other major head-group classes of membrane glycerolipids subtly fluctuated.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3APlant%5C+secondary%5C+metabolites%5C+are%5C+a%5C+class%5C+of%5C+small%5C+molecular%5C+compounds%5C+which%5C+are%5C+not%5C+necessary%5C+for%5C+plant%5C+growth%5C+and%5C+development%5C+in%5C+nature.%5C+They%5C+have%5C+many%5C+types%5C+and%5C+different%5C+functions.%5C+The%5C+current%5C+studies%5C+about%5C+these%5C+compounds%5C+were%5C+often%5C+focused%5C+on%5C+the%5C+chemistry%2C%5C+pharmacology%5C+and%5C+drug%5C+development.%5C+Research%5C+about%5C+their%5C+biological%5C+effects%5C+is%5C+few.%5C+Exploration%5C+the%5C+biological%5C+effects%5C+of%5C+plant%5C+secondary%5C+metabolites%5C+is%5C+important%5C+to%5C+study%5C+their%5C+biological%5C+function%5C+and%5C+application.%5C+Scutellarin%5C+is%5C+an%5C+active%5C+pharmaceutical%5C+ingredient%5C+extracted%5C+from%5C+Erigeron%5C+breviscapus%5C%28vant%5C%29%5C+Hand%5C+Mass.%5C+It%5C+is%5C+an%5C+important%5C+plant%5C+secondary%5C+metabolite%2C%5C+belonging%5C+to%5C+flavonoid.%5C+Previous%5C+studies%5C+found%5C+that%5C+some%5C+flavonoids%5C+such%5C+as%5C+quercetin%2C%5C+naringenin%5C+were%5C+auxin%5C+transport%5C+inhibitors%5C+in%5C+plants%5C+and%5C+they%5C+were%5C+related%5C+to%5C+plant%5C+growth%5C+and%5C+development%5C+closely.%5C+As%5C+an%5C+important%5C+flavonoid%2C%5C+scutellarin%5C+also%5C+plays%5C+an%5C+important%5C+role%5C+in%5C+plant%5C+growth%5C+and%5C+development%5C+is%5C+unknown.%5C+In%5C+this%5C+paper%2C%5C+scutellarin%5C+was%5C+selected%5C+as%5C+research%5C+object.%5C+Through%5C+a%5C+series%5C+of%5C+plant%5C+physiological%2C%5C+biochemical%5C+and%5C+molecular%5C+techniques%5C+to%5C+explore%5C+the%5C+biological%5C+effects%5C+of%5C+scutellarin%5C+on%5C+Arabidopsis%5C+thaliana%2C%5C+we%5C+get%5C+the%5C+results%5C+as%5C+follows%5C%3A%5C+Scutellarin%5C+had%5C+a%5C+hormone%5C-like%5C+effect%5C+on%5C+Arabidopsis%5C+thaliana.%5C+It%5C+promoted%5C+root%5C+elongation%5C+at%5C+low%5C+concentration%5C+obviously%5C%3B%5C+however%5C+the%5C+effect%5C+disappeared%5C+at%5C+high%5C+concentration.%5C+We%5C+made%5C+a%5C+further%5C+study%5C+about%5C+it%5C+and%5C+found%5C+that%5C+scutellarin%5C+had%5C+antagonism%5C+with%5C+methyl%5C+jasmonate%5C+and%5C+2%2C4%5C-dichlorophenoxy%5C+acetic%5C+acid%5C+%5C%282%2C4%5C-D%5C%29%5C+in%5C+root%5C+elongation.%5C+It%5C+also%5C+had%5C+an%5C+influence%5C+on%5C+nitrogen%5C+metabolism.%5C+Microarray%5C+results%5C+showed%5C+that%5C+the%5C+biological%5C+effects%5C+of%5C+scutellarin%5C+had%5C+a%5C+complex%5C+relationship%5C+with%5C+plant%5C+hormone%5C+and%5C+nitrogen%5C+metabolism.%5C+These%5C+were%5C+consistent%5C+with%5C+our%5C+experimental%5C+phenomenas.%5C+All%5C+these%5C+manifested%5C+that%5C+scutellarin%5C+played%5C+an%5C+important%5C+role%5C+in%5C+plant%5C+growth%5C+and%5C+development%5C+as%5C+a%5C+similar%5C+plant%5C+hormone.%5C+We%5C+tried%5C+the%5C+experiment%5C+using%5C+some%5C+other%5C+flavonoids.%5C+It%5C+was%5C+found%5C+that%5C+not%5C+all%5C+the%5C+flavonoids%5C+had%5C+the%5C+same%5C+obvious%5C+effects%5C+on%5C+root%5C+elongation%5C+like%5C+scutellarin%5C%3B%5C+the%5C+biological%5C+effects%5C+of%5C+them%5C+were%5C+closely%5C+related%5C+to%5C+their%5C+chemical%5C+structures.%5C+In%5C+addition%2C%5C+the%5C+other%5C+two%5C+aspects%5C+of%5C+research%5C+were%5C+also%5C+carried%5C+out%5C+in%5C+the%5C+paper.%5C+One%5C+was%5C+exploring%5C+the%5C+role%5C+of%5C+phospholipase%5C+D%CE%B4%5C+%5C%28PLD%CE%B4%5C%29%5C+under%5C+ultraviolet%5C+radiation%5C+in%5C+Arabidopsis.%5C+Our%5C+evidences%5C+suggested%5C+knockout%5C+PLD%CE%B4%5C+intensified%5C+membrane%5C+damage%5C+induced%5C+by%5C+UV%5C+radiation.%5C+The%5C+other%5C+one%5C+was%5C+lipid%5C+data%5C+collection%5C+and%5C+calculation%5C+of%5C+acyl%5C+chain%5C+lengths%5C+of%5C+lipid%5C+molecules%5C+in%5C+Arabidopsis%5C+under%5C+senescence%5C+induced%5C+by%5C+various%5C+stresses.%5C+We%5C+showed%5C+that%5C+the%5C+acyl%5C+chains%5C+of%5C+phosphoserine%5C+%5C%28PS%2C%5C+a%5C+head%5C-group%5C+class%5C+of%5C+membrane%5C+glycerolipids%5C+with%5C+very%5C+long%5C+chains%5C+of%5C+fatty%5C+acids.%5C%29%5C+lengthened%5C+with%5C+the%5C+development%5C+and%5C+senescence%5C+in%5C+Arabidopsis.%5C+In%5C+contrast%2C%5C+the%5C+acyl%5C+chain%5C+lengths%5C+of%5C+other%5C+major%5C+head%5C-group%5C+classes%5C+of%5C+membrane%5C+glycerolipids%5C+subtly%5C+fluctuated."},{"jsname":"Pulverolide, a new butenolide-type fungal pigment with a rare 2H-furo[3,2-b]chromen-2-one skeleton isolated from Pulveroboltus ravenelii, showed potentiating α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor activity. Therefore, it was considered to be a promising candidate treating Alzheimer’s and dysmnesia disease. Total synthesis of pulverolide together with its analogues and further investigations on its pharmacological activity are important to find new medicines for treatment of Alzhermeri’s disease.Chapter 1 elaborated the study on total synthesis of pulverolide. Three different approaches for the synthesis with same starting materials isovanillin and phenylacetic acid have been investigated. In the first synthetic route, 2,5-diphenyl-pentanoate was designed as a key intermediate via Michael addition reaction for the synthesis. In the second method, similar structure of chromene was used as an intermediate material to synthesize the target molecule. In the third approach, there are two key steps included to synthesize pulverolide. One is the development of 5-(hydroxyl(phenyl)methyl)-3-phenyl-tetromic acid aldol reaction and another is an aromatization reaction step with microwave. As a result, the first total synthesis of pulverolide has been successfully achieved through the third route, and the original proposed structure was revised. Microwave heating enhanced aromatization was the highlight. The original synthesis route has been shortened and several analogues were obtained through this manner.In Chapters 2-4, chemical constituents of seven higher fungi were studied. There are including Boletus edulis, B. aereus, Leccinum crocipodium, Polyporus ellisii, Coltricia perennis, Catathelasma ventricosum and Hygrophorus camarophyllus collected from Yunnan Province, P. R. China. More than 60 different compounds, including two news, (1S)-(4-acetylphenyl)-1,2-ethanediol and (1S)-(3-ethenylphenyl)-1,2-ethanediol, were isolated and identified. Four phenyl-1,2-ethanediols and one Al(Ⅲ) complex desferriferricrocin were isolated from B. edulis for the first time.Chapter 5 is a review on chemical constituents of Boletaceae. The paper provides 184 structurally diverse compounds published between 1975-2009, and 51 references.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3APulverolide%2C%5C+a%5C+new%5C+butenolide%5C-type%5C+fungal%5C+pigment%5C+with%5C+a%5C+rare%5C+2H%5C-furo%5C%5B3%2C2%5C-b%5C%5Dchromen%5C-2%5C-one%5C+skeleton%5C+isolated%5C+from%5C+Pulveroboltus%5C+ravenelii%2C%5C+showed%5C+potentiating%5C+%CE%B1%5C-amino%5C-3%5C-hydroxy%5C-5%5C-methyl%5C-4%5C-isoxazolepropionic%5C+acid%5C+%5C%28AMPA%5C%29%5C+receptor%5C+activity.%5C+%5C+Therefore%2C%5C+it%5C+was%5C+considered%5C+to%5C+be%5C+a%5C+promising%5C+candidate%5C+treating%5C+Alzheimer%E2%80%99s%5C+and%5C+dysmnesia%5C+disease.%5C+%5C+Total%5C+synthesis%5C+of%5C+pulverolide%5C+together%5C+with%5C+its%5C+analogues%5C+and%5C+further%5C+investigations%5C+on%5C+its%5C+pharmacological%5C+activity%5C+are%5C+important%5C+to%5C+find%5C+new%5C+medicines%5C+for%5C+treatment%5C+of%5C+Alzhermeri%E2%80%99s%5C+disease.Chapter%5C+1%5C+elaborated%5C+the%5C+study%5C+on%5C+total%5C+synthesis%5C+of%5C+pulverolide.%5C+%5C+Three%5C+different%5C+approaches%5C+for%5C+the%5C+synthesis%5C+with%5C+same%5C+starting%5C+materials%5C+isovanillin%5C+and%5C+phenylacetic%5C+acid%5C+have%5C+been%5C+investigated.%5C+%5C+In%5C+the%5C+first%5C+synthetic%5C+route%2C%5C+2%2C5%5C-diphenyl%5C-pentanoate%5C+was%5C+designed%5C+as%5C+a%5C+key%5C+intermediate%5C+via%5C+Michael%5C+addition%5C+reaction%5C+for%5C+the%5C+synthesis.%5C+%5C+In%5C+the%5C+second%5C+method%2C%5C+similar%5C+structure%5C+of%5C+chromene%5C+was%5C+used%5C+as%5C+an%5C+intermediate%5C+material%5C+to%5C+synthesize%5C+the%5C+target%5C+molecule.%5C+%5C+In%5C+the%5C+third%5C+approach%2C%5C+there%5C+are%5C+two%5C+key%5C+steps%5C+included%5C+to%5C+synthesize%5C+pulverolide.%5C+One%5C+is%5C+the%5C+development%5C+of%5C+5%5C-%5C%28hydroxyl%5C%28phenyl%5C%29methyl%5C%29%5C-3%5C-phenyl%5C-tetromic%5C+acid%5C+aldol%5C+reaction%5C+and%5C+another%5C+is%5C+an%5C+aromatization%5C+reaction%5C+step%5C+with%5C+microwave.%5C+%5C+As%5C+a%5C+result%2C%5C+the%5C+first%5C+total%5C+synthesis%5C+of%5C+pulverolide%5C+has%5C+been%5C+successfully%5C+achieved%5C+through%5C+the%5C+third%5C+route%2C%5C+and%5C+the%5C+original%5C+proposed%5C+structure%5C+was%5C+revised.%5C+%5C+Microwave%5C+heating%5C+enhanced%5C+aromatization%5C+was%5C+the%5C+highlight.%5C+%5C+The%5C+original%5C+synthesis%5C+route%5C+has%5C+been%5C+shortened%5C+and%5C+several%5C+analogues%5C+were%5C+obtained%5C+through%5C+this%5C+manner.In%5C+Chapters%5C+2%5C-4%2C%5C+chemical%5C+constituents%5C+of%5C+seven%5C+higher%5C+fungi%5C+were%5C+studied.%5C+There%5C+are%5C+including%5C+Boletus%5C+edulis%2C%5C+B.%5C+aereus%2C%5C+Leccinum%5C+crocipodium%2C%5C+Polyporus%5C+ellisii%2C%5C+Coltricia%5C+perennis%2C%5C+Catathelasma%5C+ventricosum%5C+and%5C+Hygrophorus%5C+camarophyllus%5C+collected%5C+from%5C+Yunnan%5C+Province%2C%5C+P.%5C+R.%5C+China.%5C+More%5C+than%5C+60%5C+different%5C+compounds%2C%5C+including%5C+two%5C+news%2C%5C+%5C%281S%5C%29%5C-%5C%284%5C-acetylphenyl%5C%29%5C-1%2C2%5C-ethanediol%5C+and%5C+%5C%281S%5C%29%5C-%5C%283%5C-ethenylphenyl%5C%29%5C-1%2C2%5C-ethanediol%2C%5C+were%5C+isolated%5C+and%5C+identified.%5C+%5C+Four%5C+phenyl%5C-1%2C2%5C-ethanediols%5C+and%5C+one%5C+Al%5C%28%E2%85%A2%5C%29%5C+complex%5C+desferriferricrocin%5C+were%5C+isolated%5C+from%5C+B.%5C+edulis%5C+for%5C+the%5C+first%5C+time.Chapter%5C+5%5C+is%5C+a%5C+review%5C+on%5C+chemical%5C+constituents%5C+of%5C+Boletaceae.%5C+%5C+The%5C+paper%5C+provides%5C+184%5C+structurally%5C+diverse%5C+compounds%5C+published%5C+between%5C+1975%5C-2009%2C%5C+and%5C+51%5C+references."},{"jsname":"Seeds contain the entire genetic information of plants, which enable to develop the technology of seed preservation for the conservation of plant diversity. The mechanism of cell death in seeds, which are induced by ageing of orthodox seeds and desiccation of recalcitrant and intermediate seeds are two important areas in seed biology but poorly understood.Those two areas were investigated in this dissertation, and Pisum sativum, Camellia sinensis var. assamica, Castanea mollissima were chosen to represent orthodox, intermediate and recalcitrant seeds respectively as studied models. Biophysical, biochemical and molecular methods were employed to investigate the cell death mechanism during seeds ageing and desiccation.First of all, Ageing induced porgrammed cell death in seeds.The morphology change, nucleic acid integrity, and gene expression during ageing of Pisum sativum seeds were investigated.The data above confirmed that PCD is an underlying mechanism of seed mortality. Moreover, glutathione played an important function during seeds ageing.An increase in glutathione redox potential (EGSSG/2GSH) while seed lost viability was discovered during ageing of P. sativum seeds. Seed viability decreased 50% when EGSSG/2GSH attained values of -180 to -160 mV, which proved that EGSSG/2GSH was a marker for seeds viability. Secondely,Reactive oxygen species plays different roles in the seed germination after desiccation. After different desiccation treatments on the tea (C. sinensis var. assamica) seeds, the relationship between ROS dose and the viability of seeds after desication treatment was investigated. The results demonstrated that the presence of ROS could released the damage of desiccation on the tea seeds. Thridly,the composition of membrane lipid species and the change during desiccation in seeds with different storage behavior. Cell membrane is very sensitive to environment, and adjust the composition of lipid molecules is one of the main methord for cell to response the environmental changes. There is a rule that phosphatidic acid (PA), with special structure, is very sensitive to temperature and water stress, and the increase of PA content indicates the damage of the cell membrane. ESI/MS-MS technology was used to analysis and compare the composition and changes membrane lipid species during desiccation treatments of Pisum sativum, Camellia sinensis var. assamica, Castanea mollissima seeds which represented orthodox, intermediate and recalcitrant seeds respectively. The results showed that the responses of PA to dehydration in embryonic axis of orhtordox and recalcitrant seeds were different. The percentage increasement of PA in orthodox seed during desiccation was not incredible and the level of PA decreased and achieved the same level as controled, while PA level increased dramatically without showing any decrease trend in recalcitrant seed, which indicated that the damage to membrane of recalcitrant seeds was inevitable. Those results indicted that the dehydration might induced reversible memebrane damage in the orthodox seed, which may result in no affect on the seed viability, while it might induced irreversible membrane damage to the recalcitrant seed, which inducned the dramatically reduce of viabiligy and cell death in the end. It was the first time to investigate and analysis systematically the composition and changes of membrane lipids of different storage behavior seeds during desiccation. It was first time to report the relationship between PA and the seeds storeage and the change of PA level in seeds could be used as the marker to diagnose.the property of seeds for desiccation sensitivity or desiccation tolerance","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3ASeeds%5C+contain%5C+the%5C+entire%5C+genetic%5C+information%5C+of%5C+plants%2C%5C+which%5C+enable%5C+to%5C+develop%5C+the%5C+technology%5C+of%5C+seed%5C+preservation%5C+for%5C+the%5C+conservation%5C+of%5C+plant%5C+diversity.%5C+The%5C+mechanism%5C+of%5C+cell%5C+death%5C+in%5C+seeds%2C%5C+which%5C+are%5C+induced%5C+by%5C+ageing%5C+of%5C+orthodox%5C+seeds%5C+and%5C+desiccation%5C+of%5C+recalcitrant%5C+and%5C+intermediate%5C+seeds%5C+are%5C+two%5C+important%5C+areas%5C+in%5C+seed%5C+biology%5C+but%5C+poorly%5C+understood.Those%5C+two%5C+areas%5C+were%5C+investigated%5C+in%5C+this%5C+dissertation%2C%5C+and%5C+Pisum%5C+sativum%2C%5C+Camellia%5C+sinensis%5C+var.%5C+assamica%2C%5C+Castanea%5C+mollissima%5C+were%5C+chosen%5C+to%5C+represent%5C+orthodox%2C%5C+intermediate%5C+and%5C+recalcitrant%5C+seeds%5C+respectively%5C+as%5C+studied%5C+models.%5C+Biophysical%2C%5C+biochemical%5C+and%5C+molecular%5C+methods%5C+were%5C+employed%5C+to%5C+investigate%5C+the%5C+cell%5C+death%5C+mechanism%5C+during%5C+seeds%5C+ageing%5C+and%5C+desiccation.First%5C+of%5C+all%2C%5C+Ageing%5C+induced%5C+porgrammed%5C+cell%5C+death%5C+in%5C+seeds.The%5C+morphology%5C+change%2C%5C+nucleic%5C+acid%5C+integrity%2C%5C+and%5C+gene%5C+expression%5C+during%5C+ageing%5C+of%5C+Pisum%5C+sativum%5C+seeds%5C+were%5C+investigated.The%5C+data%5C+above%5C+confirmed%5C+that%5C+PCD%5C+is%5C+an%5C+underlying%5C+mechanism%5C+of%5C+seed%5C+mortality.%5C+Moreover%2C%5C+glutathione%5C+played%5C+an%5C+important%5C+function%5C+during%5C+seeds%5C+ageing.An%5C+increase%5C+in%5C+glutathione%5C+redox%5C+potential%5C+%5C%28EGSSG%5C%2F2GSH%5C%29%5C+while%5C+seed%5C+lost%5C+viability%5C+was%5C+discovered%5C+during%5C+ageing%5C+of%5C+P.%5C+sativum%5C+seeds.%5C+Seed%5C+viability%5C+decreased%5C+50%25%5C+when%5C+EGSSG%5C%2F2GSH%5C+attained%5C+values%5C+of%5C+%5C-180%5C+to%5C+%5C-160%5C+mV%2C%5C+which%5C+proved%5C+that%5C+EGSSG%5C%2F2GSH%5C+was%5C+a%5C+marker%5C+for%5C+seeds%5C+viability.%5C+Secondely%2CReactive%5C+oxygen%5C+species%5C+plays%5C+different%5C+roles%5C+in%5C+the%5C+seed%5C+germination%5C+after%5C+desiccation.%5C+After%5C+different%5C+desiccation%5C+treatments%5C+on%5C+the%5C+tea%5C+%5C%28C.%5C+sinensis%5C+var.%5C+assamica%5C%29%5C+seeds%2C%5C+the%5C+relationship%5C+between%5C+ROS%5C+dose%5C+and%5C+the%5C+viability%5C+of%5C+seeds%5C+after%5C+desication%5C+treatment%5C+was%5C+investigated.%5C+The%5C+results%5C+demonstrated%5C+that%5C+the%5C+presence%5C+of%5C+ROS%5C+could%5C+released%5C+the%5C+damage%5C+of%5C+desiccation%5C+on%5C+the%5C+tea%5C+seeds.%5C+Thridly%2Cthe%5C+composition%5C+of%5C+membrane%5C+lipid%5C+species%5C+and%5C+the%5C+change%5C+during%5C+desiccation%5C+in%5C+seeds%5C+with%5C+different%5C+storage%5C+behavior.%5C+Cell%5C+membrane%5C+is%5C+very%5C+sensitive%5C+to%5C+environment%2C%5C+and%5C+adjust%5C+the%5C+composition%5C+of%5C+lipid%5C+molecules%5C+is%5C+one%5C+of%5C+the%5C+main%5C+methord%5C+for%5C+cell%5C+to%5C+response%5C+the%5C+environmental%5C+changes.%5C+There%5C+is%5C+a%5C+rule%5C+that%5C+phosphatidic%5C+acid%5C+%5C%28PA%5C%29%2C%5C+with%5C+special%5C+structure%2C%5C+is%5C+very%5C+sensitive%5C+to%5C+temperature%5C+and%5C+water%5C+stress%2C%5C+and%5C+the%5C+increase%5C+of%5C+PA%5C+content%5C+indicates%5C+the%5C+damage%5C+of%5C+the%5C+cell%5C+membrane.%5C+ESI%5C%2FMS%5C-MS%5C+technology%5C+was%5C+used%5C+to%5C+analysis%5C+and%5C+compare%5C+the%5C+composition%5C+and%5C+changes%C2%A0membrane%5C+lipid%5C+species%5C+during%5C+desiccation%5C+treatments%5C+of%5C+Pisum%5C+sativum%2C%5C+Camellia%5C+sinensis%5C+var.%5C+assamica%2C%5C+Castanea%5C+mollissima%5C+seeds%5C+which%5C+represented%5C+orthodox%2C%5C+intermediate%5C+and%5C+recalcitrant%5C+seeds%5C+respectively.%5C+The%5C+results%5C+showed%5C+that%5C+the%5C+responses%5C+of%5C+PA%5C+to%5C+dehydration%5C+in%5C+embryonic%5C+axis%5C+of%5C+orhtordox%5C+and%5C+recalcitrant%5C+seeds%5C+were%5C+different.%5C+The%5C+percentage%5C+increasement%5C+of%5C+PA%5C+in%5C+orthodox%5C+seed%5C+during%5C+desiccation%5C+was%5C+not%5C+incredible%5C+and%5C+the%5C+level%5C+of%5C+PA%5C+decreased%5C+and%5C+achieved%5C+the%5C+same%5C+level%5C+as%5C+controled%2C%5C+while%5C+PA%5C+level%5C+increased%5C+dramatically%5C+without%5C+showing%5C+any%5C+decrease%5C+trend%5C+in%5C+recalcitrant%5C+seed%2C%5C+which%5C+indicated%5C+that%5C+the%5C+damage%5C+to%5C+membrane%5C+of%5C+recalcitrant%5C+seeds%5C+was%5C+inevitable.%C2%A0Those%5C+results%5C+indicted%5C+that%5C+the%5C+dehydration%5C+might%5C+induced%5C+reversible%5C+memebrane%5C+damage%5C+in%5C+the%5C+orthodox%5C+seed%2C%5C+which%5C+may%5C+result%5C+in%5C+no%5C+affect%5C+on%5C+the%5C+seed%5C+viability%2C%5C+while%5C+it%5C+might%5C+induced%5C+irreversible%5C+membrane%5C+damage%5C+to%5C+the%5C+recalcitrant%5C+seed%2C%5C+which%5C+inducned%5C+the%5C+d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Master degree thesis studied on the chemical constituents and bioactivities of Azadirachta indica and Jatropha curcas which both have insecticidal activity. 58 compounds, including four new ones, were isolated and identified from this two species by various chromatographic processes. The cytotoxicities of some compounds obtained from Azadirachta indica were evaluated. Finally, this thesis also made a review on the chemical constituents and bioactivities from plants of genus Melia. Chapter 1 Chemical constituents and bioactivities of Azadirachta indica，From the methanol extract of branches and leaves of Azadirachta indicia, 53 compounds, including four new ones, were isolated and identified based on spectral techniques. These compounds referred to sesquiterpenoids, triterpenoids, steroids and flavonoids. Two of the new compounds were C30 triterpenoids and the other two were tetranortriterpenoids. 26 compounds were evaluated for their cytotoxicities and some were found to have potential cytotoxicities. The abundant constituent, nimbolide, showed strong cytotoxicities against all the tested cell lines. Chapter 2 Chemical constituents of Jatropha curcas，Nine known compounds were isolated from the methanol extract of branches and leaves of J. curcas. Chapter 3 Review on chemical constituents and bioactivities of genus Melia，This chapter made a review on the chemical constituents and bioactivities of genus Melia based on the literatures which were reported before 2010.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3AThe%5C+Master%5C+degree%5C+thesis%5C+studied%5C+on%5C+the%5C+chemical%5C+constituents%5C+and%5C+bioactivities%5C+of%5C+Azadirachta%5C+indica%5C+and%5C+Jatropha%5C+curcas%5C+which%5C+both%5C+have%5C+insecticidal%5C+activity.%5C+58%5C+compounds%2C%5C+including%5C+four%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+this%5C+two%5C+species%5C+by%5C+various%5C+chromatographic%5C+processes.%5C+The%5C+cytotoxicities%5C+of%5C+some%5C+compounds%5C+obtained%5C+from%5C+Azadirachta%5C+indica%5C+were%5C+evaluated.%5C+Finally%2C%5C+this%5C+thesis%5C+also%5C+made%5C+a%5C+review%5C+on%5C+the%5C+chemical%5C+constituents%5C+and%5C+bioactivities%5C+from%5C+plants%5C+of%5C+genus%5C+Melia.%5C+Chapter%5C+1%5C+Chemical%5C+constituents%5C+and%5C+bioactivities%5C+of%5C+Azadirachta%5C+indica%EF%BC%8CFrom%5C+the%5C+methanol%5C+extract%5C+of%5C+branches%5C+and%5C+leaves%5C+of%5C+Azadirachta%5C+indicia%2C%5C+53%5C+compounds%2C%5C+including%5C+four%5C+new%5C+ones%2C%5C+were%5C+isolated%5C+and%5C+identified%5C+based%5C+on%5C+spectral%5C+techniques.%5C+These%5C+compounds%5C+referred%5C+to%5C+sesquiterpenoids%2C%5C+triterpenoids%2C%5C+steroids%5C+and%5C+flavonoids.%5C+Two%5C+of%5C+the%5C+new%5C+compounds%5C+were%5C+C30%5C+triterpenoids%5C+and%5C+the%5C+other%5C+two%5C+were%5C+tetranortriterpenoids.%5C+26%5C+compounds%5C+were%5C+evaluated%5C+for%5C+their%5C+cytotoxicities%5C+and%5C+some%5C+were%5C+found%5C+to%5C+have%5C+potential%5C+cytotoxicities.%5C+The%5C+abundant%5C+constituent%2C%5C+nimbolide%2C%5C+showed%5C+strong%5C+cytotoxicities%5C+against%5C+all%5C+the%5C+tested%5C+cell%5C+lines.%5C+Chapter%5C+2%5C+Chemical%5C+constituents%5C+of%5C+Jatropha%5C+curcas%EF%BC%8CNine%5C+known%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+methanol%5C+extract%5C+of%5C+branches%5C+and%5C+leaves%5C+of%5C+J.%5C+curcas.%5C+Chapter%5C+3%5C+Review%5C+on%5C+chemical%5C+constituents%5C+and%5C+bioactivities%5C+of%5C+genus%5C+Melia%EF%BC%8CThis%5C+chapter%5C+made%5C+a%5C+review%5C+on%5C+the%5C+chemical%5C+constituents%5C+and%5C+bioactivities%5C+of%5C+genus%5C+Melia%5C+based%5C+on%5C+the%5C+literatures%5C+which%5C+were%5C+reported%5C+before%5C+2010."},{"jsname":"The chemical constituents of eight higher fungi and one medicinal plant were investigated. The fungi included Trametes corrugate, Campanella junghuhnii, Craterellus cornucopioides, Phlebia radiate, Laccaria amethystea, Hydnochaete sp., Nidula sp. and Rhodophyllus ater, which are all collected from Yunnan province, P. R. China. The leaves of Cynara scolymus L. (Artichoke) were collected from south of Vietnam. 119 compounds, including 91 different compounds and 9 new ones, have been obtained using varied chromatographic methods, and the structures of new metabolites were elucidated on the basis of extensive spectroscopic analysis including IR, UV, MS, 1D- and 2D-NMR experiments.Two unusual diterpenes (13-14) with neodolastane skeletons were isolated and identified from the culture broth of Trametes corrugate. This type of diterpene was obtained for the first time from higer fungi. A new tricyclo[6.3.1.02,5]dodecane sesquiterpene (1) was isolated from the culture broth of Campanella junghuhnii. Three new keto esters (65-67) and a series of illudine sesquiterpenes (4-10) were isolated and identified from the culture broth of the basidiomycete Craterellus cornucopioides. A new fatty acid ester (48) was isolated from the culture broth of Phlebia radiate.A new isoprenyl phenyl ether riboside (68) was isolated from culture broth of Laccaria amethystea. During our studies on chemical constituents of the culture broth of Hydnochaete sp., a conjugate lactone (71) was obtained. Preliminary biological assay showed that the lactone exhibited inhibitory activity against the11b-hydroxysteroid dehydrogenase (11β-HSD1) of human and mouse with IC50 value of 53.338 mg/mL and 95.950 mg/mL, respectively. A new guaiane-type sesquiterpene lactone (2) and a new phenolic glucoside gallate (69) were isolated and identified from the leaves of Cynara scolymus (Artichoke). A review summarized their structures, biological activities, and the producing species of naturally occurring triterpenes from higher fungi. The paper provides 433 structurally diverse compounds published between 1985~2010, and 114 references.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3AThe%5C+chemical%5C+constituents%5C+of%5C+eight%5C+higher%5C+fungi%5C+and%5C+one%5C+medicinal%5C+plant%5C+were%5C+investigated.%5C+The%5C+fungi%5C+included%5C+Trametes%5C+corrugate%2C%5C+Campanella%5C+junghuhnii%2C%5C+Craterellus%5C+cornucopioides%2C%5C+Phlebia%5C+radiate%2C%5C+Laccaria%5C+amethystea%2C%5C+Hydnochaete%5C+sp.%2C%5C+Nidula%5C+sp.%5C+and%5C+Rhodophyllus%5C+ater%2C%5C+which%5C+are%5C+all%5C+collected%5C+from%5C+Yunnan%5C+province%2C%5C+P.%5C+R.%5C+China.%5C+The%5C+leaves%5C+of%5C+Cynara%5C+scolymus%5C+L.%5C+%5C%28Artichoke%5C%29%5C+were%5C+collected%5C+from%5C+south%5C+of%5C+Vietnam.%5C+119%5C+compounds%2C%5C+including%5C+91%5C+different%5C+compounds%5C+and%5C+9%5C+new%5C+ones%2C%5C+have%5C+been%5C+obtained%5C+using%5C+varied%5C+chromatographic%5C+methods%2C%5C+and%5C+the%5C+structures%5C+of%5C+new%5C+metabolites%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis%5C+including%5C+IR%2C%5C+UV%2C%5C+MS%2C%5C+1D%5C-%5C+and%5C+2D%5C-NMR%5C+experiments.Two%5C+unusual%5C+diterpenes%5C+%5C%2813%5C-14%5C%29%5C+with%5C+neodolastane%5C+skeletons%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Trametes%5C+corrugate.%5C+This%5C+type%5C+of%5C+diterpene%5C+was%5C+obtained%5C+for%5C+the%5C+first%5C+time%5C+from%5C+higer%5C+fungi.%5C+A%5C+new%5C+tricyclo%5C%5B6.3.1.02%2C5%5C%5Ddodecane%5C+sesquiterpene%5C+%5C%281%5C%29%5C+was%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Campanella%5C+junghuhnii.%5C+Three%5C+new%5C+keto%5C+esters%5C+%5C%2865%5C-67%5C%29%5C+and%5C+a%5C+series%5C+of%5C+illudine%5C+sesquiterpenes%5C+%5C%284%5C-10%5C%29%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+the%5C+basidiomycete%5C+Craterellus%5C+cornucopioides.%5C+A%5C+new%5C+fatty%5C+acid%5C+ester%5C+%5C%2848%5C%29%5C+was%5C+isolated%5C+from%5C+the%5C+culture%5C+broth%5C+of%5C+Phlebia%5C+radiate.A%5C+new%5C+isoprenyl%5C+phenyl%5C+ether%5C+riboside%5C+%5C%2868%5C%29%5C+was%5C+isolated%5C+from%5C+culture%5C+broth%5C+of%5C+Laccaria%5C+amethystea.%5C+During%5C+our%5C+studies%5C+on%5C+chemical%5C+constituents%5C+of%5C+the%5C+culture%5C+broth%5C+of%5C+Hydnochaete%5C+sp.%2C%5C+a%5C+conjugate%5C+lactone%5C+%5C%2871%5C%29%5C+was%5C+obtained.%5C+Preliminary%5C+biological%5C+assay%5C+showed%5C+that%5C+the%5C+lactone%5C+exhibited%5C+inhibitory%5C+activity%5C+against%5C+the11b%5C-hydroxysteroid%5C+dehydrogenase%5C+%5C%2811%CE%B2%5C-HSD1%5C%29%5C+of%5C+human%5C+and%5C+mouse%5C+with%5C+IC50%5C+value%5C+of%5C+53.338%5C+mg%5C%2FmL%5C+and%5C+95.950%5C+mg%5C%2FmL%2C%5C+respectively.%5C+A%5C+new%5C+guaiane%5C-type%5C+sesquiterpene%5C+lactone%5C+%5C%282%5C%29%5C+and%5C+a%5C+new%5C+phenolic%5C+glucoside%5C+gallate%5C+%5C%2869%5C%29%5C+were%5C+isolated%5C+and%5C+identified%5C+from%5C+the%5C+leaves%5C+of%5C+Cynara%5C+scolymus%5C+%5C%28Artichoke%5C%29.%5C+A%5C+review%5C+summarized%5C+their%5C+structures%2C%5C+biological%5C+activities%2C%5C+and%5C+the%5C+producing%5C+species%5C+of%5C+naturally%5C+occurring%5C+triterpenes%5C+from%5C+higher%5C+fungi.%5C+The%5C+paper%5C+provides%5C+433%5C+structurally%5C+diverse%5C+compounds%5C+published%5C+between%5C+1985%5C%7E2010%2C%5C+and%5C+114%5C+references."},{"jsname":"The chemical constituents of six higher fungi including Gomphus floccosus, Marasmius maximus Hongo, Paxillus panuoides, Tylopilus felleus, Cantharellus cibarius and Grifola frondosa collected from Yunnan Province, P. R. China, and a medicinal plant Hypericum reptans, were investigated.43 Compounds including 3 new ones have been obtained by chromatographic methods, and their structures were elucidated on the basis of spectroscopic data (1D NMR, 2D NMR, MS, HR-MS, UV/Vis) in combination with single-crystal X-ray diffraction analysis.Two new furanone derivatives, (E)-3-(1,3-butadienyl)-4-(3-oxopentyl)-2(5H)-furanone (1), 3-((S,E)-3,4-dihydroxy-butylenyl)-4-((S,E)-3-hydroxy-pentenyl)-2(5H)-furanone (2) which had a large conjugated systemGomphus floccosus. The absolute configurations of 2 were determined based on the modified Moshers method after selectively protected the primary alcohol group in the 1,2-primary/secondary diol. in the structures, were isolated from the culture of the basidiomycete. A new compound based on a dibenzodioxinone skeleton was isolated from the medical plant Hypericum reptans. The plane structure and relative configurations of the new compound was elucidated by spectroscopic data and further confirmed by single-crystal X-ray diffraction.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3AThe%5C+chemical%5C+constituents%5C+of%5C+six%5C+higher%5C+fungi%5C+including%5C+Gomphus%5C+floccosus%2C%5C+Marasmius%5C+maximus%5C+Hongo%2C%5C+Paxillus%5C+panuoides%2C%5C+Tylopilus%5C+felleus%2C%5C+Cantharellus%5C+cibarius%5C+and%5C+Grifola%5C+frondosa%5C+collected%5C+from%5C+Yunnan%5C+Province%2C%5C+P.%5C+R.%5C+China%2C%5C+and%5C+a%5C+medicinal%5C+plant%5C+Hypericum%5C+reptans%2C%5C+were%5C+investigated.43%5C+Compounds%5C+including%5C+3%5C+new%5C+ones%5C+have%5C+been%5C+obtained%5C+by%5C+chromatographic%5C+methods%2C%5C+and%5C+their%5C+structures%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+spectroscopic%5C+data%5C+%5C%281D%5C+NMR%2C%5C+2D%5C+NMR%2C%5C+MS%2C%5C+HR%5C-MS%2C%5C+UV%5C%2FVis%5C%29%5C+in%5C+combination%5C+with%5C+single%5C-crystal%5C+X%5C-ray%5C+diffraction%5C+analysis.Two%5C+new%5C+furanone%5C+derivatives%2C%5C+%5C%28E%5C%29%5C-3%5C-%5C%281%2C3%5C-butadienyl%5C%29%5C-4%5C-%5C%283%5C-oxopentyl%5C%29%5C-2%5C%285H%5C%29%5C-furanone%5C+%5C%281%5C%29%2C%5C+3%5C-%5C%28%5C%28S%2CE%5C%29%5C-3%2C4%5C-dihydroxy%5C-butylenyl%5C%29%5C-4%5C-%5C%28%5C%28S%2CE%5C%29%5C-3%5C-hydroxy%5C-pentenyl%5C%29%5C-2%5C%285H%5C%29%5C-furanone%5C+%5C%282%5C%29%5C+which%5C+had%5C+a%5C+large%5C+conjugated%5C+systemGomphus%5C+floccosus.%5C+The%5C+absolute%5C+configurations%5C+of%5C+2%5C+were%5C+determined%5C+based%5C+on%5C+the%5C+modified%5C+Moshers%5C+method%5C+after%5C+selectively%5C+protected%5C+the%5C+primary%5C+alcohol%5C+group%5C+in%5C+the%5C+1%2C2%5C-primary%5C%2Fsecondary%5C+diol.%5C+in%5C+the%5C+structures%2C%5C+were%5C+isolated%5C+from%5C+the%5C+culture%5C+of%5C+the%5C+basidiomycete.%5C+A%5C+new%5C+compound%5C+based%5C+on%5C+a%5C+dibenzodioxinone%5C+skeleton%5C+was%5C+isolated%5C+from%5C+the%5C+medical%5C+plant%5C+Hypericum%5C+reptans.%5C+The%5C+plane%5C+structure%5C+and%5C+relative%5C+configurations%5C+of%5C+the%5C+new%5C+compound%5C+was%5C+elucidated%5C+by%5C+spectroscopic%5C+data%5C+and%5C+further%5C+confirmed%5C+by%5C+single%5C-crystal%5C+X%5C-ray%5C+diffraction."},{"jsname":"The chemistry constitutes and their anti-tobacco mosic virus activity from two species of Simaroubeaceae, namely Brucea javanica (L) Merr. and Harrisonia perforata (Blanco) Merr have been investigated.. By variety of chromatographies over various materials, Eighty-seven compounds were isolated from the two plants and eighty of them were identified， of which twenty-two were new compounds and one of them was a novel nortriterpenoids with unprecedented skeleton and another showed the polymorphism. A series of C-20 quassinoids with potent anti-tobacco mosic virus (TMV) activity was found by the bioassay-guided isolation of the seed of Brucea javanica. The characteristic secondary metabolites of Simaroubeaceae--quassinoids were reviewed. Chapter 1, phytochemistry investigation on the seed of Brucea javanica (L) Merr. has led to isolation of 41 compounds, and 34 of them were identified, including 17 quassinoids with anti-TMV activity. Among them compounds 1 and 2 were new quassinoids. Others were alkaloids, ligands, sequiterpenoids, and so on. Chapter 2, tobacco mosic virus inhibiting activity of quassinoids from Brucea javanica (L) Merr. From bioassay-guide isolation 17 quassinoids with potent anti-TMV activities were isolated from the seeds of Brucea javanica (L) Merr. Based on the results of in vivo and in vitro experiments, it was showed that those compounds can both inhibit virus infection and multiplication of TMV. The anti-TMV structure activity relationships were also discussed. Chapter 3, phytochemistry investigation on the leaves and branches of H. perforata has lead to isolation of 32 compounds and 31 were identified, including 20 new limonoids. Among them 1 was a novel limonoids with unprecedented skeleton, and another showed the polymorphism. Besides, 14 compounds, including 8 limonoids along with some triterpenoids, ligands and flavonoids were isolated from the fruit of H. perforata. Among the 14 compounds 1-3 were novel limonoids which have been isolated from the leaves and branches of this species. The limonoids isolated from H. perforata showed structure similarity with those from the Ptaeroxylaceae and Cneoraceae. Furthermore, most of them were the key intermediates of the biogenetic pathway previously proposed by Dr. Xin Fang of our research group. Based on the biogenetic pathway and structure similarity of limonoids it was suggested that the genus of Harrisonia has a very close relationship with Ptaeroxylaceae and Cneoraceae. Chapter 4, reviewed the progress on the phytochemistry study of the quassinoids of Simaroubaceae. The bioactivities along with proposed biogenetic pathway involving quassinoids reported from the Simaroubeaceae were systemically.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3AThe%5C+chemistry%5C+constitutes%5C+and%5C+their%5C+anti%5C-tobacco%5C+mosic%5C+virus%5C+activity%5C+from%5C+two%5C+species%5C+of%5C+Simaroubeaceae%2C%5C+namely%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+and%5C+Harrisonia%5C+perforata%5C+%5C%28Blanco%5C%29%5C+Merr%5C+have%5C+been%5C+investigated..%5C+By%5C+variety%5C+of%5C+chromatographies%5C+over%5C+various%5C+materials%2C%5C+Eighty%5C-seven%5C+compounds%5C+were%5C+isolated%5C+from%5C+the%5C+two%5C+plants%5C+and%5C+eighty%5C+of%5C+them%5C+were%5C+identified%EF%BC%8C%5C+of%5C+which%5C+twenty%5C-two%5C+were%5C+new%5C+compounds%5C+and%5C+one%5C+of%5C+them%5C+was%5C+a%5C+novel%5C+nortriterpenoids%5C+with%5C+unprecedented%5C+skeleton%5C+and%5C+another%5C+showed%5C+the%5C+polymorphism.%5C+A%5C+series%5C+of%5C+C%5C-20%5C+quassinoids%5C+with%5C+potent%5C+anti%5C-tobacco%5C+mosic%5C+virus%5C+%5C%28TMV%5C%29%5C+activity%5C+was%5C+found%5C+by%5C+the%5C+bioassay%5C-guided%5C+isolation%5C+of%5C+the%5C+seed%5C+of%5C+Brucea%5C+javanica.%5C+The%5C+characteristic%5C+secondary%5C+metabolites%5C+of%5C+Simaroubeaceae%5C-%5C-quassinoids%5C+were%5C+reviewed.%5C+Chapter%5C+1%2C%5C+phytochemistry%5C+investigation%5C+on%5C+the%5C+seed%5C+of%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+has%5C+led%5C+to%5C+isolation%5C+of%5C+41%5C+compounds%2C%5C+and%5C+34%5C+of%5C+them%5C+were%5C+identified%2C%5C+including%5C+17%5C+quassinoids%5C+with%5C+anti%5C-TMV%5C+activity.%5C+Among%5C+them%5C+compounds%5C+1%5C+and%5C+2%5C+were%5C+new%5C+quassinoids.%5C+Others%5C+were%5C+alkaloids%2C%5C+ligands%2C%5C+sequiterpenoids%2C%5C+and%5C+so%5C+on.%5C+Chapter%5C+2%2C%5C+tobacco%5C+mosic%5C+virus%5C+inhibiting%5C+activity%5C+of%5C+quassinoids%5C+from%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+From%5C+bioassay%5C-guide%5C+isolation%5C+17%5C+quassinoids%5C+with%5C+potent%5C+anti%5C-TMV%5C+activities%5C+were%5C+isolated%5C+from%5C+the%5C+seeds%5C+of%5C+Brucea%5C+javanica%5C+%5C%28L%5C%29%5C+Merr.%5C+Based%5C+on%5C+the%5C+results%5C+of%5C+in%5C+vivo%5C+and%5C+in%5C+vitro%5C+experiments%2C%5C+it%5C+was%5C+showed%5C+that%5C+those%5C+compounds%5C+can%5C+both%5C+inhibit%5C+virus%5C+infection%5C+and%5C+multiplication%5C+of%5C+TMV.%5C+The%5C+anti%5C-TMV%5C+structure%5C+activity%5C+relationships%5C+were%5C+also%5C+discussed.%5C+Chapter%5C+3%2C%5C+phytochemistry%5C+investigation%5C+on%5C+the%5C+leaves%5C+and%5C+branches%5C+of%5C+H.%5C+perforata%5C+has%5C+lead%5C+to%5C+isolation%5C+of%5C+32%5C+compounds%5C+and%5C+31%5C+were%5C+identified%2C%5C+including%5C+20%5C+new%5C+limonoids.%5C+Among%5C+them%5C+1%5C+was%5C+a%5C+novel%5C+limonoids%5C+with%5C+unprecedented%5C+skeleton%2C%5C+and%5C+another%5C+showed%5C+the%5C+polymorphism.%5C+Besides%2C%5C+14%5C+compounds%2C%5C+including%5C+8%5C+limonoids%5C+along%5C+with%5C+some%5C+triterpenoids%2C%5C+ligands%5C+and%5C+flavonoids%5C+were%5C+isolated%5C+from%5C+the%5C+fruit%5C+of%5C+H.%5C+perforata.%5C+Among%5C+the%5C+14%5C+compounds%5C+1%5C-3%5C+were%5C+novel%5C+limonoids%5C+which%5C+have%5C+been%5C+isolated%5C+from%5C+the%5C+leaves%5C+and%5C+branches%5C+of%5C+this%5C+species.%5C+The%5C+limonoids%5C+isolated%5C+from%5C+H.%5C+perforata%5C+showed%5C+structure%5C+similarity%5C+with%5C+those%5C+from%5C+the%5C+Ptaeroxylaceae%5C+and%5C+Cneoraceae.%5C+Furthermore%2C%5C+most%5C+of%5C+them%5C+were%5C+the%5C+key%5C+intermediates%5C+of%5C+the%5C+biogenetic%5C+pathway%5C+previously%5C+proposed%5C+by%5C+Dr.%5C+Xin%5C+Fang%5C+of%5C+our%5C+research%5C+group.%5C+Based%5C+on%5C+the%5C+biogenetic%5C+pathway%5C+and%5C+structure%5C+similarity%5C+of%5C+limonoids%5C+it%5C+was%5C+suggested%5C+that%5C+the%5C+genus%5C+of%5C+Harrisonia%5C+has%5C+a%5C+very%5C+close%5C+relationship%5C+with%5C+Ptaeroxylaceae%5C+and%5C+Cneoraceae.%5C+Chapter%5C+4%2C%5C+reviewed%5C+the%5C+progress%5C+on%5C+the%5C+phytochemistry%5C+study%5C+of%5C+the%5C+quassinoids%5C+of%5C+Simaroubaceae.%5C+The%5C+bioactivities%5C+along%5C+with%5C+proposed%5C+biogenetic%5C+pathway%5C+involving%5C+quassinoids%5C+reported%5C+from%5C+the%5C+Simaroubeaceae%5C+were%5C+systemically."},{"jsname":"The dissertation deals with the chemical constituents of six plants, Brainea insignis, Dipteris chinensis, Lygodium japonicum, Hypericum lagarocladum, Hypericum androsaemum, and Uncaria macrophylla. More than 100 compounds, including 18 new ones, were obtained using varied chromatography methods, and the structures of them were elucidated on the basis of extensive spectroscopic analysis. The classifications of new compounds include flavonoids, diterpenoids, polycyclic polyprenylated acylphloroglucinols (PPAPs), and oxindole alkaloids, etc. Brainicin was an unusual flavan derivative with a linkage between C-4 of epicatechin and the side chain of a phenylpropyl unit isolated from B. insignis. The type of linkage was found for the first time in nature. A series of new polycyclic polyprenylated acylphloroglucinols (PPAPs) possessing a spirocyclic skeleton, were found in H. lagarocladum. Hyperandrone A, a complex adamantyl derivative was the first example of PPAPs from H. androsaemum. Macrophyllionium, the first example of a zwitterionic oxindole alkaloid was isolated from the aerial parts of U. macrophylla. It extended the structural variety of the known betaines. Macrophyllines A and B were a pair of isomers with acetonyl in skeleton compared with other analogues, and they were proved to be natural products. In addition, some compounds were evaluated for their cytotoxicity against five human cancer cell lines and vasodilative effects on KCl-/phenylephrine (PE)-induced contraction. As a result, corynantheidine exhibited cytotoxicity against HL-60 and SW480 cells with IC50 values of 13.96 and 23.28 μM, respectively; macrophylline A, isorhynchophylline, and dihydrocorynantheine showed strong inhibitory action on KCl-/PE-induced contraction. It was noteworthy that dihydrocorynantheine almost inhibited completely PE-induced contraction in rats thoracic aorta at 30 μg/ml. In contrast to the relatively smaller inhibitory effects of verapamil on PE-induced contraction at 3 and 10 μg/ml, dihydrocorynantheine showed significant inhibitory actions. It was shown to be a potent vasorelaxant of aorta. Finally, a review titled advances of chemistry and pharmacology of the genus Uncaria is presented.","jscount":"1","jsurl":"/simple-search?field1=all&rpp=10&accurate=false&advanced=false&sort_by=2&isNonaffiliated=false&search_type=-1&query1=%25E8%2591%25A1%25E8%2590%2584%25E7%25B3%2596&order=desc&&fq=dc.project.title_filter%3AThe%5C+dissertation%5C+deals%5C+with%5C+the%5C+chemical%5C+constituents%5C+of%5C+six%5C+plants%2C%5C+Brainea%5C+insignis%2C%5C+Dipteris%5C+chinensis%2C%5C+Lygodium%5C+japonicum%2C%5C+Hypericum%5C+lagarocladum%2C%5C+Hypericum%5C+androsaemum%2C%5C+and%5C+Uncaria%5C+macrophylla.%5C+More%5C+than%5C+100%5C+compounds%2C%5C+including%5C+18%5C+new%5C+ones%2C%5C+were%5C+obtained%5C+using%5C+varied%5C+chromatography%5C+methods%2C%5C+and%5C+the%5C+structures%5C+of%5C+them%5C+were%5C+elucidated%5C+on%5C+the%5C+basis%5C+of%5C+extensive%5C+spectroscopic%5C+analysis.%5C+The%5C+classifications%5C+of%5C+new%5C+compounds%5C+include%5C+flavonoids%2C%5C+diterpenoids%2C%5C+polycyclic%5C+polyprenylated%5C+acylphloroglucinols%5C+%5C%28PPAPs%5C%29%2C%5C+and%5C+oxindole%5C+alkaloids%2C%5C+etc.%5C+Brainicin%5C+was%5C+an%5C+unusual%5C+flavan%5C+derivative%5C+with%5C+a%5C+linkage%5C+between%5C+C%5C-4%5C+of%5C+epicatechin%5C+and%5C+the%5C+side%5C+chain%5C+of%5C+a%5C+phenylpropyl%5C+unit%5C+isolated%5C+from%5C+B.%5C+insignis.%5C+The%5C+type%5C+of%5C+linkage%5C+was%5C+found%5C+for%5C+the%5C+first%5C+time%5C+in%5C+nature.%C2%A0A%5C+series%5C+of%5C+new%5C+polycyclic%5C+polyprenylated%5C+acylphloroglucinols%5C+%5C%28PPAPs%5C%29%5C+possessing%5C+a%5C+spirocyclic%5C+skeleton%2C%5C+were%5C+found%5C+in%5C+H.%5C+lagarocladum.%5C+Hyperandrone%5C+A%2C%5C+a%5C+complex%5C+adamantyl%5C+derivative%5C+was%5C+the%5C+first%5C+example%5C+of%5C+PPAPs%5C+from%5C+H.%5C+androsaemum.%5C+Macrophyllionium%2C%5C+the%5C+first%5C+example%5C+of%5C+a%5C+zwitterionic%5C+oxindole%5C+alkaloid%5C+was%5C+isolated%5C+from%5C+the%5C+aerial%5C+parts%5C+of%5C+U.%5C+macrophylla.%5C+It%5C+extended%5C+the%5C+structural%5C+variety%5C+of%5C+the%5C+known%5C+betaines.%5C+Macrophyllines%5C+A%5C+and%5C+B%5C+were%5C+a%5C+pair%5C+of%5C+isomers%5C+with%5C+acetonyl%5C+in%5C+skeleton%5C+compared%5C+with%5C+other%5C+analogues%2C%5C+and%5C+they%5C+were%5C+proved%5C+to%5C+be%5C+natural%5C+products.%5C+In%5C+addition%2C%5C+some%5C+compounds%5C+were%5C+evaluated%5C+for%5C+their%5C+cytotoxicity%5C+against%5C+five%5C+human%5C+cancer%5C+cell%5C+lines%5C+and%5C+vasodilative%5C+effects%5C+on%5C+KCl%5C-%5C%2Fphenylephrine%5C+%5C%28PE%5C%29%5C-induced%5C+contraction.%5C+As%5C+a%5C+result%2C%5C+corynantheidine%5C+exhibited%5C+cytotoxicity%5C+against%5C+HL%5C-60%5C+and%5C+SW480%5C+cells%5C+with%5C+IC50%5C+values%5C+of%5C+13.96%5C+and%5C+23.28%5C+%CE%BCM%2C%5C+respectively%5C%3B%5C+macrophylline%5C+A%2C%5C+isorhynchophylline%2C%5C+and%5C+dihydrocorynantheine%5C+showed%5C+strong%5C+inhibitory%5C+action%5C+on%5C+KCl%5C-%5C%2FPE%5C-induced%5C+contraction.%5C+It%5C+was%5C+noteworthy%5C+that%5C+dihydrocorynantheine%5C+almost%5C+inhibited%5C+completely%5C+PE%5C-induced%5C+contraction%5C+in%5C+rats%5C+thoracic%5C+aorta%5C+at%5C+30%5C+%CE%BCg%5C%2Fml.%5C+In%5C+contrast%5C+to%5C+the%5C+relatively%5C+smaller%5C+inhibitory%5C+effects%5C+of%5C+verapamil%5C+on%5C+PE%5C-induced%5C+contraction%5C+at%5C+3%5C+and%5C+10%5C+%CE%BCg%5C%2Fml%2C%5C+dihydrocorynantheine%5C+showed%5C+significant%5C+inhibitory%5C+actions.%5C+It%5C+was%5C+shown%5C+to%5C+be%5C+a%5C+potent%5C+vasorelaxant%5C+of%5C+aorta.%5C+Finally%2C%5C+a%5C+review%5C+titled%5C+advances%5C+of%5C+chemistry%5C+and%5C+pharmacology%5C+of%5C+the%5C+genus%5C+Uncaria%5C+is%5C+presented."},{"jsname":"lastIndexed","jscount":"2024-06-11"}],"资助项目","dc.project.title_filter")'>
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紫花碎米荠的化学成分研究
期刊论文
出版物, 3111, 期号: 0, 页码: 1—7
作者:
紫花碎米荠
;
化学成分
;
黄酮
Adobe PDF(1085Kb)
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浏览/下载：236/2
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提交时间：2017/07/24
灯台叶总生物碱中鸭脚树叶碱及瓦莱萨明碱大鼠在体肠吸收特性
期刊论文
出版物, 3111, 期号: 0, 页码: 1—5
作者:
贺俊杰
;
刘璇
;
陈彦
;
曹伟
;
袁菱
Adobe PDF(372Kb)
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提交时间：2017/07/24
灯台叶
鸭脚树叶碱
瓦莱萨明碱
在体肠灌流
吸收
为建设自主创新体系提供科技信息支撑
期刊论文
出版物, 3111, 期号: 0, 页码: 1—2
作者:
作者
Adobe PDF(328Kb)
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提交时间：2017/07/21
可作药用的花卉（下）
期刊论文
华中农业大学图书馆, 3111, 页码: 23
作者:
何永进
Adobe PDF(71Kb)
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提交时间：2017/07/19
顽拗性种子种质保存现象
期刊论文
出版物, 3111, 页码: 37-40
作者:
陆旺金
;
傅家瑞
Adobe PDF(147Kb)
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提交时间：2017/07/19
类谷氨酸受体GLR3.3和GLR3.6调控拟南芥系统性抗虫响应 的机理研究
学位论文
: 中国科学院大学, 2022
作者:
薛娜
Adobe PDF(9018Kb)
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浏览/下载：28/0
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提交时间：2024/05/14
类谷氨酸受体，系统性信号，桃蚜，斜纹夜蛾
Glutamate receptor-like genes, Systemic signaling, Myzus persicae, Spodoptera litura
蜜环菌遗传转化体系的构建及应用
学位论文
: 中国科学院大学, 2022
作者:
粟忠祥
Adobe PDF(19175Kb)
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提交时间：2024/05/14
蜜环菌,遗传转化,转基因技术,RNAi
Armillaria,Genetic transformation,Transgenic technology,RNAi
墨西哥海参(Holothuria mexicane)糖胺聚糖结构分析与抗P-选择素活性评价
学位论文
: 中国科学院大学, 2022
作者:
潘颖
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提交时间：2024/05/14
墨西哥海参，岩藻糖化硫酸软骨素，结构分析，二糖侧链，P-选择素
Holothuria mexicane, Fucosylated chondroitin sulfate, Structure analysis, Disaccharide branch, P-selectin
海菜花的化学成分及其生物活性研究
学位论文
: 中国科学院大学, 2022
作者:
刘洪星
Adobe PDF(6132Kb)
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提交时间：2024/05/14
海菜花，Ottelione，二芳基庚烷，糖尿病，抗肿瘤
Ottelia acuminata, Ottelione, Diarylheptanoids, DM, Antitumor
西印度醋栗果实的化学成分研究
学位论文
: 中国科学院大学, 2022
作者:
胥佳
Adobe PDF(5962Kb)
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浏览/下载：13/0
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提交时间：2024/05/14
大戟科，西印度醋栗，化学成分，生物活性，营养分析
Euphorbiaceae, Phyllanthus acidus (L.) Skeels, Chemical constituents, Biological activity, Nutritional analysis
