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Design, Synthesis, and Biological Activities of Vibsanin B Derivatives: A New Class of HSP90 C-Terminal Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 21, 页码: 9053-9066
作者:  Shao, Li-Dong;  Su, Jia;  Ye, Baixin;  Liu, Jiang-Xin;  Zuo, Zhi-Li;  Li, Yan;  Wang, Yue-Ying;  Xia, Chengfeng;  Zhao, Qin-Shi
浏览  |  Adobe PDF(5724Kb)  |  收藏  |  浏览/下载：397/45  |  提交时间：2017/12/18
Vibsane-type diterpenes from leaves and twigs of Viburnum odoratissimum 期刊论文
FITOTERAPIA, 2016, 卷号: 109, 页码: 224-229
作者:  He, Juan;  Peng, Li-Yan;  Tu, Lin;  Wu, Xing-De;  Dong, Liao-Bing;  Pan, Zheng-Hong;  Chen, Xuan-Qin;  Su, Jia;  Zhao, Yu;  Xu, Gang;  Cheng, Xiao;  Li, Yan;  Zhao, Qin-Shi
浏览  |  Adobe PDF(446Kb)  |  收藏  |  浏览/下载：279/93  |  提交时间：2016/08/22
Viburnum Odoratissimum  Vibsane-type Diterpenes  Vibsanols C-h  Vibsanin x  Cytotoxicity  
Identification and validation of p50 as the cellular target of eriocalyxin B 期刊论文
ONCOTARGET, 2014, 卷号: 5, 期号: 22, 页码: 11354-11364
作者:  Kong, Ling-Mei;  Deng, Xu;  Zuo, Zhi-Li;  Sun, Han-Dong;  Zhao, Qin-Shi;  Li, Yan
浏览  |  Adobe PDF(3014Kb)  |  收藏  |  浏览/下载：309/80  |  提交时间：2015/06/17
Erib  Activity-based Probes  P50  Nf-kappa b Signaling  Apoptosis  
Vincamajorines A and B, monoterpenoid indole alkaloids with new carbon skeletons from Vinca major 期刊论文
TETRAHEDRON LETTERS, 2014, 卷号: 55, 期号: 47, 页码: 6490-6494
作者:  Zhang, Zhi-Jun;  Yang, Jing;  He, Juan;  Wu, Xing-De;  Shao, Li-Dong;  Li, Yan;  Huang, Sheng-Xiong;  Li, Rong-Tao;  Zhao, Qin-Shi;  Li,RT (reprint author),Kunming Univ Sci & Technol,Fac Life Sci & Technol,Chenggong Campus,Kunming 650050,Yunnan,Peoples R China.;  rongtaolikm@163.com;  qinshizhao@mail.kib.ac.cn
浏览  |  Adobe PDF(763Kb)  |  收藏  |  浏览/下载：319/77  |  提交时间：2015/01/20
Vinca Major  Monoterpenoid Indole Alkaloids  Quantum Chemical Calculations  
Identification of two novel inhibitors of mTOR signaling pathway based on high content screening 期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2013, 卷号: 72, 期号: 4, 页码: 799-808
作者:  Yan, Juming;  Zhou, Hongyu;  Kong, Lingmei;  Zhang, Jing;  Zhao, Qinshi;  Li, Yan
浏览  |  Adobe PDF(1971Kb)  |  收藏  |  浏览/下载：696/109  |  提交时间：2013/11/12
Mtor Signaling  Inhibitor  High Content Screening  Cancer  Apoptosis  
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:  Zhao, Yu;  Su, Jia;  Goto, Masuo;  Morris-Natschke, Susan L.;  Li, Yan;  Zhao, Qin-Shi;  Yao, Zhu-Jun;  Lee, Kuo-Hsiung
浏览  |  Adobe PDF(531Kb)  |  收藏  |  浏览/下载：326/73  |  提交时间：2013/10/16
Natural-products  Biological-activity  Cancer-therapy  Paclitaxel  Taxol  Resistance  Drugs  Chemotherapy  Parthenolide  Brevifoliol  
Development of novel conformation-constrained cytotoxic derivatives of cheliensisin A by embedment of small heterocycles 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 4238-4244
作者:  Deng, Xu;  Su, Jia;  Zhao, Yu;  Peng, Li-Yan;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(450Kb)  |  收藏  |  浏览/下载：404/101  |  提交时间：2012/03/16
Cheliensisin a  Derivative  Structure-activity Relationship  Cytotoxicity  Anticancer  
Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues 期刊论文
TETRAHEDRON LETTERS, 2011, 卷号: 52, 期号: 1, 页码: 139-142
作者:  Zhao, Yu;  Zhang, Hong-Bin;  Liu, Ji-Kai;  Su, Jia;  Li, Yan;  Yao, Zhu-Jun;  Zhao, Qin-Shi
Adobe PDF(602Kb)  |  收藏  |  浏览/下载：374/124  |  提交时间：2012/04/10
Taxyunnansin a  Abeo-taxoids  Fragmentation  Abeo-paclitaxel  Anticancer