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Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer 期刊论文
BIOLOGY OPEN, 2019, 卷号: 8, 期号: 11, 页码: 9
作者:  Duan, Aizhu;  Kong, Lingmei;  An, Tao;  Zhou, Hongyu;  Yu, Chunlei;  Li, Yan
浏览  |  Adobe PDF(2302Kb)  |  收藏  |  浏览/下载：281/67  |  提交时间：2020/03/02
Star-PAP  TPD52  miR-449a  miR-34a  Breast cancer  
B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells 期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 18, 页码: 3371-3386
作者:  Zhou, Hongyu;  Yu, Chunlei;  Kong, Lingmei;  Xu, Xiaoliang;  Yan, Juming;  Li, Yingchao;  An, Tao;  Gong, Liang;  Gong, Yaxiao;  Zhu, Huifang;  Zhang, Hongbin;  Yang, Xiaodong;  Li, Yan
浏览  |  Adobe PDF(5225Kb)  |  收藏  |  浏览/下载：265/36  |  提交时间：2019/06/24
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model 期刊论文
CELL DEATH & DISEASE, 2017, 卷号: 8, 期号: 1, 页码: e2582
作者:  Yu, C.;  Gong, Y.;  Zhou, H.;  Wang, M.;  Kong, L.;  Liu, J.;  An, T.;  Zhu, H.;  Li, Y.
浏览  |  Adobe PDF(3022Kb)  |  收藏  |  浏览/下载：210/48  |  提交时间：2017/04/19
N-Hydroxyphthalimide exhibits antitumor activity by suppressing mTOR signaling pathway in BT-20 and LoVo cells 期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 卷号: 35
作者:  Wang, Min;  Zhou, Ankun;  An, Tao;  Kong, Lingmei;  Yu, Chunlei;  Liu, Jianmei;  Xia, Chengfeng;  Zhou, Hongyu;  Li, Yan
浏览  |  Adobe PDF(1734Kb)  |  收藏  |  浏览/下载：247/60  |  提交时间：2016/06/27
N-hydroxyphthalimide  Mtor  Inhibitor  Cancer  Mitochondrial Apoptosis  
Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase 期刊论文
PHARMACEUTICAL BIOLOGY, 2014, 卷号: 52, 期号: 1, 页码: 68-73
作者:  Wang, Fang;  Yan, Juming;  Niu, Yanfen;  Li, Yan;  Lin, Hua;  Liu, Xu;  Liu, Jikai;  Li, Ling
浏览  |  Adobe PDF(383Kb)  |  收藏  |  浏览/下载：303/67  |  提交时间：2014/04/09
Active Metabolite  Ampk  Insulin Resistance  L6 Muscle Cells  Norathyriol  
Trichothecin Induces Cell Death in NF-kappa B Constitutively Activated Human Cancer Cells via Inhibition of IKK beta Phosphorylation 期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 8, 页码: e71333
作者:  Su, Jia;  Zhao, Peiji;  Kong, Lingmei;  Li, Xingyao;  Yan, Juming;  Zeng, Ying;  Li, Yan
浏览  |  Adobe PDF(1124Kb)  |  收藏  |  浏览/下载：335/68  |  提交时间：2013/11/12
Colitis-associated Cancer  Multiple-myeloma Cells  P65 Phosphorylation  Endophytic Fungus  Kinase-activity  Tumor-growth  In-vitro  Pathway  Apoptosis  Inflammation  
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua
Adobe PDF(6299Kb)  |  收藏  |  浏览/下载：286/50  |  提交时间：2015/05/14
One Of The Major compOnents Isolated From The Traditional  2-methyl-1  Chinese Medicine Rubia Yunnanensis  3  Exhibited Inhibitory Activity On The proliferatiOn Of Several  6-trihydroxy-9  HumAn CAncer Cell Lines. The Results From An Annexin V-fitc (fluoresein-5-isothiocyAnate) Apoptosis Assay  10-anthraquinone (Mta)  And Dna Content Analysis Showed That Mta Exerted Cytotoxicity Via Apoptosis Induction And G2/m Cell Cycle  Arrest In Human Cervical carcInoma Hela Cells. Further  Mta Was Found To Induce apopTosis Of Hela Cells  Through The MITochondria-mediated Pathway. It Caused The Translocation Of Bax To The mITochondria And  Release Of Cytochrome c Into The Cytosol  Which Caused The Cleavage Of Caspase And Poly(Adp-ribose)  Polymerase And Finally Triggered The Apoptosis. furThermore  The P53/p21/cdc2-cyclin B1 Signaling Was  Found Related To The G2/m Arrest Caused By Mta. The Over-expression Of P21 And Down-expression Of  Cyclin B1 Caused By Mta Inactivated The cdc2-Cyclin B1 Complex Of G2/m Checkpoint And Finally Caused  The G2/m Arrest In Hela Cells. ThIs Study Demonstrated That Mta Is a Potential Anti-cancer Component Of  R. Yunnanensis  a Folk Anti-cancer Herb Used In Yunnan  China.