×
验证码:
换一张
忘记密码?
记住我
×
登录
中文版
|
English
中国科学院昆明植物研究所知识管理系统
Knowledge Management System of Kunming Institute of Botany,CAS
登录
注册
ALL
ORCID
题名
作者
学科领域
关键词
资助项目
文献类型
出处
收录类别
出版者
发表日期
存缴日期
学科门类
学习讨论厅
图片搜索
粘贴图片网址
首页
研究单元&专题
作者
文献类型
学科分类
知识图谱
新闻&公告
研究单元&专题
中国科学院东亚植... [406]
共享文献 [314]
昆明植物所硕博研... [190]
资源植物与生物技术... [98]
中国西南野生生物种... [41]
植物化学与西部植物... [31]
更多...
作者
孙航 [92]
周浙昆 [66]
李德铢 [63]
许建初 [63]
杨祝良 [55]
邓涛 [42]
更多...
文献类型
期刊论文 [1024]
学位论文 [190]
专著 [52]
其他 [5]
会议录 [2]
会议论文 [2]
更多...
发表日期
2021 [49]
2020 [98]
2019 [87]
2018 [71]
2017 [73]
2016 [82]
更多...
语种
英语 [779]
中文 [173]
出处
FUNGAL DI... [55]
JOURNAL O... [41]
MOLECULAR... [36]
PHYTOTAXA [29]
BOTANICAL... [22]
TAXON [22]
更多...
资助项目
0.05) between wild (AR = 4.651), semi-cultivated (AR = 5.091) and cultivated (AR = 5.132) populations of C. taliensis, which suggested that the genetic background of long-lived woody plant was not easy to be changed, and there were moderate high gene flow between populations. However, there was a significant difference (P < 0.05) between wild (AR = 5.9) and cultivated (AR = 7.1) populations distributed in the same place in Yun county, Yunnan province, which may result from the hybridization and introgression of species in the tea garden and anthropogenic damages to the wild population. The hypothesis of hybrid origin of C. grandibracteata was tested by morphological and microsatellites analyses. Compared with other species, the locules in ovary of C. grandibracteata are variable, which showed a morphological intermediate and mosaic. Except one private allele, Ninety-nine percent alleles of C. grandibracteata were shared with these of C. taliensis and C. sinensis var. assamica. And C. grandibracteata was nested in the cluster of C. taliensis in the UPGMA tree. Conclusively, our results supported the hypothesis of hybrid origin of C. grandibracteata partly. The speciation of C. grandibracteata was derived from hybridization and asymmetrical introgression potentially. It is possible that C. taliensis was one of its parents, but it still needs more evidences to prove that C. sinensis var. assamica was another parent.","jscount":"1","jsurl":"/simple-search?field1=all&field=eperson.unique.id&advanced=false&query1=Western%2BNorth-america&&fq=dc.project.title_filter%3ACamellia%5C+taliensis%5C+%5C%28W.%5C+W.%5C+Smith%5C%29%5C+Melchior%2C%5C+a%5C+member%5C+of%5C+Camellia%5C+sect.%5C+Thea%2C%5C+is%5C+an%5C+indigenous%5C+species%5C+in%5C+local%5C+natural%5C+forest%5C+and%5C+has%5C+a%5C+long%5C+cultivative%5C+history%5C+in%5C+western%5C+Yunnan%5C+and%5C+its%5C+neighborhood%2C%5C+where%5C+the%5C+domestications%5C+of%5C+this%5C+species%5C+in%5C+different%5C+historical%5C+periods%5C+and%5C+in%5C+different%5C+ways%5C+can%5C+be%5C+found.%5C+C.%5C+taliensis%5C+is%5C+an%5C+important%5C+contributor%5C+to%5C+the%5C+formations%5C+of%5C+tea%5C+landraces%5C+by%5C+hybridization%5C+and%5C+introgression.%5C+In%5C+the%5C+present%5C+study%2C%5C+14%5C+microsatellite%5C+loci%5C+screened%5C+from%5C+37%5C+loci%5C+were%5C+used%5C+to%5C+explore%5C+the%5C+genetic%5C+diversity%5C+about%5C+this%5C+species%5C+with%5C+579%5C+samples%5C+from%5C+25%5C+populations%5C+%5C%2816%5C+wild%5C+populations%2C%5C+4%5C+semi%5C-cultivated%5C+populations%5C+and%5C+5%5C+cultivated%5C+populations%5C%29.%5C+At%5C+the%5C+same%5C+time%2C%5C+the%5C+potential%5C+hybrid%5C+speciation%5C+of%5C+C.%5C+grandibracteata%2C%5C+was%5C+investigated%5C+using%5C+39%5C+individuals%5C+from%5C+2%5C+populations%2C%5C+along%5C+with%5C+C.%5C+taliensis%5C+and%5C+C.%5C+sinensis%5C+var.%5C+assamica%5C+%5C%2883%5C+individuals%5C+from%5C+4%5C+populations%5C%29%5C+by%5C+the%5C+same%5C+microsatellite%5C+markers.%5C+C.%5C+taliensis%5C+had%5C+a%5C+moderate%5C+high%5C+level%5C+of%5C+genetic%5C+diversity%5C+%5C%28A%5C+%3D%5C+14.3%2C%5C+Ne%3D%5C+5.7%2C%5C+HE%5C+%3D%5C+0.666%2C%5C+I%5C+%3D%5C+1.753%2C%5C+AR%5C+%3D%5C+7.2%2C%5C+PPB%5C+%3D%5C+100%25%5C%29.%5C+This%5C+may%5C+result%5C+from%5C+several%5C+factors%5C+including%5C+K%5C-strategy%2C%5C+genetic%5C+background%2C%5C+gene%5C+flow%5C+between%5C+populations%2C%5C+hybridization%5C+and%5C+introgression%5C+among%5C+species.%5C+Between%5C+wild%5C+populations%5C+of%5C+C.%5C+taliensis%2C%5C+the%5C+gene%5C+flow%5C+was%5C+moderate%5C+high%5C+%5C%28Nm%5C+%3D%5C+1.197%5C%29%2C%5C+and%5C+genetic%5C+variation%5C+was%5C+less%5C+than%5C+20%25%5C+%5C%28GST%5C+%3D%5C+0.147%2C%5C+FST%5C+%3D%5C+0.173%5C%29%2C%5C+which%5C+was%5C+similar%5C+to%5C+other%5C+research%5C+results%5C+of%5C+long%5C-lived%5C+woody%5C+plants%2C%5C+and%5C+reflected%5C+the%5C+genetic%5C+structure%5C+of%5C+its%5C+ancestry%5C+to%5C+same%5C+extent.%5C+There%5C+was%5C+a%5C+high%5C+significant%5C+correlation%5C+between%5C+geographic%5C+distance%5C+and%5C+Nei%E2%80%99s%5C+genetic%5C+distance%5C+%5C%28r%5C+%3D%5C+0.372%2C%5C+P%5C+%3D%5C+0.001%5C%29%5C+of%5C+populations%2C%5C+which%5C+accorded%5C+with%5C+isolation%5C+by%5C+distance%5C+model.%5C+Inferring%5C+from%5C+Bayesian%5C+clustering%5C+of%5C+genotypes%2C%5C+all%5C+individuals%5C+of%5C+C.%5C+taliensis%5C+were%5C+divided%5C+into%5C+two%5C+groups%2C%5C+conflicting%5C+with%5C+the%5C+result%5C+based%5C+on%5C+Nei%E2%80%99s%5C+genetic%5C+distance%5C+and%5C+real%5C+geographic%5C+distribution%2C%5C+which%5C+suggested%5C+there%5C+were%5C+heavy%5C+and%5C+non%5C-random%5C+influences%5C+by%5C+human%5C+practices.%5C+According%5C+to%5C+allelic%5C+richness%2C%5C+there%5C+were%5C+no%5C+significant%5C+differences%5C+%5C%28P%5C+%3E%5C+0.05%5C%29%5C+between%5C+wild%5C+%5C%28AR%5C+%3D%5C+4.651%5C%29%2C%5C+semi%5C-cultivated%5C+%5C%28AR%5C+%3D%5C+5.091%5C%29%5C+and%5C+cultivated%5C+%5C%28AR%5C+%3D%5C+5.132%5C%29%5C+populations%5C+of%5C+C.%5C+taliensis%2C%5C+which%5C+suggested%5C+that%5C+the%5C+genetic%5C+background%5C+of%5C+long%5C-lived%5C+woody%5C+plant%5C+was%5C+not%5C+easy%5C+to%5C+be%5C+changed%2C%5C+and%5C+there%5C+were%5C+moderate%5C+high%5C+gene%5C+flow%5C+between%5C+populations.%5C+However%2C%5C+there%5C+was%5C+a%5C+significant%5C+difference%5C+%5C%28P%5C+%3C%5C+0.05%5C%29%5C+between%5C+wild%5C+%5C%28AR%5C+%3D%5C+5.9%5C%29%5C+and%5C+cultivated%5C+%5C%28AR%5C+%3D%5C+7.1%5C%29%5C+populations%5C+distributed%5C+in%5C+the%5C+same%5C+place%5C+in%5C+Yun%5C+county%2C%5C+Yunnan%5C+province%2C%5C+which%5C+may%5C+result%5C+from%5C+the%5C+hybridization%5C+and%5C+introgression%5C+of%5C+species%5C+in%5C+the%5C+tea%5C+garden%5C+and%5C+anthropogenic%5C+damages%5C+to%5C+the%5C+wild%5C+population.%5C+The%5C+hypothesis%5C+of%5C+hybrid%5C+origin%5C+of%5C+C.%5C+grandibracteata%5C+was%5C+tested%5C+by%5C+morphological%5C+and%5C+microsatellites%5C+analyses.%5C+Compared%5C+with%5C+other%5C+species%2C%5C+the%5C+locules%5C+in%5C+ovary%5C+of%5C+C.%5C+grandibracteata%5C+are%5C+variable%2C%5C+which%5C+showed%5C+a%5C+morphological%5C+intermediate%5C+and%5C+mosaic.%5C+Except%5C+one%5C+private%5C+allele%2C%5C+Ninety%5C-nine%5C+percent%5C+alleles%5C+of%5C+C.%5C+grandibracteata%5C+were%5C+shared%5C+with%5C+these%5C+of%5C+C.%5C+taliensis%5C+and%5C+C.%5C+sinensis%5C+var.%5C+assamica.%5C+And%5C+C.%5C+grandibracteata%5C+was%5C+nested%5C+in%5C+the%5C+cluster%5C+of%5C+C.%5C+taliensis%5C+in%5C+the%5C+UPGMA%5C+tree.%5C+Conclusively%2C%5C+our%5C+results%5C+supported%5C+the%5C+hypothesis%5C+of%5C+hybrid%5C+origin%5C+of%5C+C.%5C+grandibracteata%5C+partly.%5C+The%5C+speciation%5C+of%5C+C.%5C+grandibracteata%5C+was%5C+derived%5C+from%5C+hybridization%5C+and%5C+asymmetrical%5C+introgression%5C+potentially.%5C+It%5C+is%5C+possible%5C+that%5C+C.%5C+taliensis%5C+was%5C+one%5C+of%5C+its%5C+parents%2C%5C+but%5C+it%5C+still%5C+needs%5C+more%5C+evidences%5C+to%5C+prove%5C+that%5C+C.%5C+sinensis%5C+var.%5C+assamica%5C+was%5C+another%5C+parent."},{"jsname":"Chemical constituents and bioactivities research on Cimicifuga species have been became an international hotspot. There are abundant plant resources of this genus in China, however the step of exploitation is far fall behind the western world. In an attempt to fully utilize our domestic resources, our research group has been studying on the chemical constituents and their bioactivities, specially 9,19-cyclolanostanetriterpenes of this genus, since 2003. As a result, several cycloartane triterpenoids with potential anti-tumor activities were obtained for the first time in China. For further searching anti-tumor lead compounds with novel structures and more potent activities, in this thesis,the roots of C. yunnanensis and the aerial parts of C. foetida, which collected from Shangrila County in Yunnan Province, the roots of C. foetida, which collected from Heishitou Town in Guizhou Province and the roots of C. dahurica and C. heracleifolia, which collected from Qingyuan County in Liaoning Province were used as experimental materials and total 105 compounds were isolated and identified by different spectroscopic and chemical methods. Among these 105 compounds, there are 94 9,19-cyclolanostanetriterpenes,including 44 new constituents. All these new compounds can be categorized as Cimigenol-type, Shengmanol-type, Hydroxyshengmanol-type, Acteol-type, Dahurinol-type, Cimicidol-type, and 3,4-Seco-type, 15,16-Seco-type, which were very novel. The left 11 compounds are normal Chromones, sitosterols, oleanane triterpenes and a new Ergostane-type steoid. The isolated 9,19-cyclolanostane compounds were tested for their cytotoxicities against 15 human carcinoma cell lines, which included human hepatoma cell line HepG2, human breast carcinoma cell line MCF-7, human colorectal carcinoma cell line HT-19 and so on. 40 compounds showed activities and three of them, which isolated from C. yunnanensis exhibited as potent activities as positive control Taxol. Mechanism research indicated that these three compounds can increase the expression of p53 and bax, which led to the loss of mitochondrial potential and then resulted in the activation of caspase-7 and induced apoptosis of MCF-7. In addition, a series of compounds which isolated from the roots of C. foetida showed selective significant cytotoxicity (potent than positive controlcisplatin) against the human HepG2 cell line and a domestic patent was applied for these compounds. A conclusion of the structure-activity relationships of Cimigenol-type compounds were proposed: one of the key point for anti-tumor activities is at least one side of the compound has hydrophobic groups such as carbonyl, double bond substitute hydroxyl groups. At the end of this thesis, a comprehensive review about the distribution and utilization of the Cimicifuga genus worldwide, the structures of 9,19-cyclolanostanetriterpenes and their anti-climacteric syndrome, anti-osteoporotic and anti-tumor activities were gave.","jscount":"1","jsurl":"/simple-search?field1=all&field=eperson.unique.id&advanced=false&query1=Western%2BNorth-america&&fq=dc.project.title_filter%3AChemical%5C+constituents%5C+and%5C+bioactivities%5C+research%5C+on%5C+Cimicifuga%5C+species%5C+have%5C+been%5C+became%5C+an%5C+international%5C+hotspot.%5C+There%5C+are%5C+abundant%5C+plant%5C+resources%5C+of%5C+this%5C+genus%5C+in%5C+China%2C%5C+however%5C+the%5C+step%5C+of%5C+exploitation%5C+is%5C+far%5C+fall%5C+behind%5C+the%5C+western%5C+world.%5C+In%5C+an%5C+attempt%5C+to%5C+fully%5C+utilize%5C+our%5C+domestic%5C+resources%2C%5C+our%5C+research%5C+group%5C+has%5C+been%5C+studying%5C+on%5C+the%5C+chemical%5C+constituents%5C+and%5C+their%5C+bioactivities%2C%5C+specially%5C+9%2C19%5C-cyclolanostanetriterpenes%5C+of%5C+this%5C+genus%2C%5C+since%5C+2003.%5C+As%5C+a%5C+result%2C%5C+several%5C+cycloartane%5C+triterpenoids%5C+with%5C+potential%5C+anti%5C-tumor%5C+activities%5C+were%5C+obtained%5C+for%5C+the%5C+first%5C+time%5C+in%5C+China.%5C+For%5C+further%5C+searching%5C+anti%5C-tumor%5C+lead%5C+compounds%5C+with%5C+novel%5C+structures%5C+and%5C+more%5C+potent%5C+activities%2C%5C+in%5C+this%5C+thesis%EF%BC%8Cthe%5C+roots%5C+of%5C+C.%5C+yunnanensis%5C+and%5C+the%5C+aerial%5C+parts%5C+of%5C+C.%5C+foetida%2C%5C+which%5C+collected%5C+from%5C+Shangrila%5C+County%5C+in%5C+Yunnan%5C+Province%2C%5C+the%5C+roots%5C+of%5C+C.%5C+foetida%2C%5C+which%5C+collected%5C+from%5C+Heishitou%5C+Town%5C+in%5C+Guizhou%5C+Province%5C+and%5C+the%5C+roots%5C+of%5C+C.%5C+dahurica%5C+and%5C+C.%5C+heracleifolia%2C%5C+which%5C+collected%5C+from%5C+Qingyuan%5C+County%5C+in%5C+Liaoning%5C+Province%5C+were%5C+used%5C+as%5C+experimental%5C+materials%5C+and%5C+total%5C+105%5C+compounds%5C+were%5C+isolated%5C+and%5C+identified%5C+by%5C+different%5C+spectroscopic%5C+and%5C+chemical%5C+methods.%5C+Among%5C+these%5C+105%5C+compounds%2C%5C+there%5C+are%5C+94%5C+9%2C19%5C-cyclolanostanetriterpenes%EF%BC%8Cincluding%5C+44%5C+new%5C+constituents.%5C+All%5C+these%5C+new%5C+compounds%5C+can%5C+be%5C+categorized%5C+as%5C+Cimigenol%5C-type%2C%5C+Shengmanol%5C-type%2C%5C+Hydroxyshengmanol%5C-type%2C%5C+Acteol%5C-type%2C%5C+Dahurinol%5C-type%2C%5C+Cimicidol%5C-type%2C%5C+and%5C+3%2C4%5C-Seco%5C-type%2C%5C+15%2C16%5C-Seco%5C-type%2C%5C+which%5C+were%5C+very%5C+novel.%5C+The%5C+left%5C+11%5C+compounds%5C+are%5C+normal%5C+Chromones%2C%5C+sitosterols%2C%5C+oleanane%5C+triterpenes%5C+and%5C+a%5C+new%5C+Ergostane%5C-type%5C+steoid.%5C+The%5C+isolated%5C+9%2C19%5C-cyclolanostane%5C+compounds%5C+were%5C+tested%5C+for%5C+their%5C+cytotoxicities%5C+against%5C+15%5C+human%5C+carcinoma%5C+cell%5C+lines%2C%5C+which%5C+included%5C+human%5C+hepatoma%5C+cell%5C+line%5C+HepG2%2C%5C+human%5C+breast%5C+carcinoma%5C+cell%5C+line%5C+MCF%5C-7%2C%5C+human%5C+colorectal%5C+carcinoma%5C+cell%5C+line%5C+HT%5C-19%5C+and%5C+so%5C+on.%5C+40%5C+compounds%5C+showed%5C+activities%5C+and%5C+three%5C+of%5C+them%2C%5C+which%5C+isolated%5C+from%5C+C.%5C+yunnanensis%5C+exhibited%5C+as%5C+potent%5C+activities%5C+as%5C+positive%5C+control%5C+Taxol.%5C+Mechanism%5C+research%5C+indicated%5C+that%5C+these%5C+three%5C+compounds%5C+can%5C+increase%5C+the%5C+expression%5C+of%5C+p53%5C+and%5C+bax%2C%5C+which%5C+led%5C+to%5C+the%5C+loss%5C+of%5C+mitochondrial%5C+potential%5C+and%5C+then%5C+resulted%5C+in%5C+the%5C+activation%5C+of%5C+caspase%5C-7%5C+and%5C+induced%5C+apoptosis%5C+of%5C+MCF%5C-7.%5C+In%5C+addition%2C%5C+a%5C+series%5C+of%5C+compounds%5C+which%5C+isolated%5C+from%5C+the%5C+roots%5C+of%5C+C.%5C+foetida%5C+showed%5C+selective%5C+significant%5C+cytotoxicity%5C+%5C%28potent%5C+than%5C+positive%5C+controlcisplatin%5C%29%5C+against%5C+the%5C+human%5C+HepG2%5C+cell%5C+line%5C+and%5C+a%5C+domestic%5C+patent%5C+was%5C+applied%5C+for%5C+these%5C+compounds.%5C+A%5C+conclusion%5C+of%5C+the%5C+structure%5C-activity%5C+relationships%5C+of%5C+Cimigenol%5C-type%5C+compounds%5C+were%5C+proposed%5C%3A%5C+one%5C+of%5C+the%5C+key%5C+point%5C+for%5C+anti%5C-tumor%5C+activities%5C+is%5C+at%5C+least%5C+one%5C+side%5C+of%5C+the%5C+compound%5C+has%5C+hydrophobic%5C+groups%5C+such%5C+as%5C+carbonyl%2C%5C+double%5C+bond%5C+substitute%5C+hydroxyl%5C+groups.%5C+At%5C+the%5C+end%5C+of%5C+this%5C+thesis%2C%5C+a%5C+comprehensive%5C+review%5C+about%5C+the%5C+distribution%5C+and%5C+utilization%5C+of%5C+the%5C+Cimicifuga%5C+genus%5C+worldwide%2C%5C+the%5C+structures%5C+of%5C+9%2C19%5C-cyclolanostanetriterpenes%5C+and%5C+their%5C+anti%5C-climacteric%5C+syndrome%2C%5C+anti%5C-osteoporotic%5C+and%5C+anti%5C-tumor%5C+activities%5C+were%5C+gave."},{"jsname":"lastIndexed","jscount":"2024-08-25"}],"资助项目","dc.project.title_filter")'>
CAS Presid... [2]
Chiang Mai... [2]
Chinese Ac... [2]
Mae Fah Lu... [2]
National S... [2]
Science Re... [2]
更多...
收录类别
SCI [578]
CSCD [31]
SSCI [13]
IC [2]
ISTP [2]
资助机构
Chinese A... [13]
CAS/SAFEA ... [9]
John D. an... [8]
National N... [7]
Chinese Ac... [6]
National N... [6]
更多...
×
知识图谱
KIB OpenIR
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
分面浏览:作者
当前检索式
((ALL:Western North-america))
限定条件
无
共115条,第1-20条
孙航
92
周浙昆
66
李德铢
63
许建初
63
杨祝良
55
邓涛
42
王红
31
赵琪
19
杨永平
19
伊廷双
19
龚洵
16
高连明
16
李嵘
13
彭华
11
刘杰
10
王立松
10
葛再伟
10
贾林波
10
yang jing
10
张建文
9