Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.

doi:10.1007/s13659-024-00479-3

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	Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.
	Wei, Yinling; Wen, Hongyan; Yang, Lian; Zhang, Bodou; Li, Xiaoyu; Li, Sheng; Dong, Jing; Liang, Zhenzhen; Zhang, Yu
	2024
发表期刊	Natural products and bioprospecting
ISSN	2192-2195
卷号	14 期号:1 页码:57-57
摘要	Four new isoquinoline alkaloids, hypecotumines A-D (1-4), were isolated and identified from the whole herbs of Hypecoum erectum L. Their structures were determined by a combination of HRESIMS, NMR, and X-ray diffraction analysis methods. Compounds 1-4 were characterized by a terminal double bond at C-9 and their plausible biosynthetic pathway was hypothesized. Since PCSK9 plays a key role in the development of cardiovascular disease (CVD), exploration of PCSK inhibitors from natural products are beneficial for drug discovery of CVD treatment. SPR and Western blot assays showed compound 4 had PCSK9 inhibition activity with KD value of 59.9M and thus elevated the LDLR level. Further molecular docking studies demonstrated that 4 and PCSK9 could form stable interactions via key hydrogen bonds.
DOI	10.1007/s13659-024-00479-3
WOS记录号	MEDLINE:39404968
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76407
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wei, Yinling,Wen, Hongyan,Yang, Lian,et al. Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.[J]. Natural products and bioprospecting,2024,14(1):57-57.
APA	Wei, Yinling.,Wen, Hongyan.,Yang, Lian.,Zhang, Bodou.,Li, Xiaoyu.,...&Zhang, Yu.(2024).Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L..Natural products and bioprospecting,14(1),57-57.
MLA	Wei, Yinling,et al."Hypecotumines A-D, new isoquinoline alkaloids with potential PCSK9 inhibition activity from Hypecoum erectum L.".Natural products and bioprospecting 14.1(2024):57-57.

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