Gold-Catalyzed Cascade Reaction of Yne-Enones with Iminooxindoles, Access to 3,2′-Pyrrolidinyl-Spirooxindole Derivatives

doi:10.1021/acs.orglett.4c01395

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	Gold-Catalyzed Cascade Reaction of Yne-Enones with Iminooxindoles, Access to 3,2′-Pyrrolidinyl-Spirooxindole Derivatives
	Liu, Yijun; Shen, Xiaojiang; Zhu, Pengyan; Hu, Jiang-Miao; Wang, Xuanjun; Ge, Shulin
	2024
发表期刊	ORGANIC LETTERS
ISSN	1523-7060
卷号	26 期号:22 页码:4654-4659
摘要	Herein, a gold-catalyzed cascade reaction of yne-enones with iminooxindoles has been developed through a cascade cycloisomerization/(3 + 2) annulation process. This approach provides a straightforward and efficient route for the synthesis of functionalized 3,2 '-pyrrolidinyl-spirooxindoles in high reactivity and broad substrate scope with excellent cis-selectivity. Moreover, the subsequent functionalization of furan units allows for the diverse synthesis of spirooxindole derivatives, which have demonstrated good antitumoral activity.
DOI	10.1021/acs.orglett.4c01395
WOS记录号	WOS:001234349700001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76381
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Liu, Yijun,Shen, Xiaojiang,Zhu, Pengyan,等. Gold-Catalyzed Cascade Reaction of Yne-Enones with Iminooxindoles, Access to 3,2′-Pyrrolidinyl-Spirooxindole Derivatives[J]. ORGANIC LETTERS,2024,26(22):4654-4659.
APA	Liu, Yijun,Shen, Xiaojiang,Zhu, Pengyan,Hu, Jiang-Miao,Wang, Xuanjun,&Ge, Shulin.(2024).Gold-Catalyzed Cascade Reaction of Yne-Enones with Iminooxindoles, Access to 3,2′-Pyrrolidinyl-Spirooxindole Derivatives.ORGANIC LETTERS,26(22),4654-4659.
MLA	Liu, Yijun,et al."Gold-Catalyzed Cascade Reaction of Yne-Enones with Iminooxindoles, Access to 3,2′-Pyrrolidinyl-Spirooxindole Derivatives".ORGANIC LETTERS 26.22(2024):4654-4659.

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