Artemsieverolactones A-H, Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana

doi:10.1002/cjoc.202300631

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	Artemsieverolactones A-H, Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana
	Dong, Wei; Huang, Xiao-Yan; Li, Tian-Ze; Weng, Yan-Mei; Geng, Chang-An; Chen, Ji-Jun
	2024
发表期刊	CHINESE JOURNAL OF CHEMISTRY
ISSN	1001-604X
卷号	42 期号:10 页码:1084-1092
摘要	Eight new guaiane-type sesquiterpenoid trimers, artemsieverolactones A-H, possessing unprecedented scaffolds via biocatalyzed [4+2] Diels-Alder cycloaddition reactions were identified from Artemisia sieversiana. Their structures were determined by comprehensive spectroscopic data, single-crystal X-ray diffraction analyses, and ECD calculations. In terms of structure, artemsieverolactones A-H are first examples of sesquiterpenoid trimers from guaiane-type sesquiterpenoid through four different [4+2] Diels-Alder cycloaddition models. Antihepatic fibrosis assay suggested that five compounds exhibited activity against HSC-LX2 with IC50 values ranging from 37.8 to 117.1 mu mol/L. The most active artemsieverolactone B (2) displayed significant inhibitory activity against HSC-LX2 with IC50 value of 37.8 mu mol/L, which was 3 times more active than the positive drug silybin (IC50, 139.7 mu mol/L). Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen type I (Col I), human hyaluronic acid (HA), and human laminin (HL) with IC50 values of 40.4 mu mol/L (Col I), 55.1 mu mol/L (HL), 47.3 mu mol/L (HA), which was 2 to 3-fold more potent than silybin.
DOI	10.1002/cjoc.202300631
WOS记录号	WOS:001150765800001
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76342
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Dong, Wei,Huang, Xiao-Yan,Li, Tian-Ze,et al. Artemsieverolactones A-H, Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana[J]. CHINESE JOURNAL OF CHEMISTRY,2024,42(10):1084-1092.
APA	Dong, Wei,Huang, Xiao-Yan,Li, Tian-Ze,Weng, Yan-Mei,Geng, Chang-An,&Chen, Ji-Jun.(2024).Artemsieverolactones A-H, Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana.CHINESE JOURNAL OF CHEMISTRY,42(10),1084-1092.
MLA	Dong, Wei,et al."Artemsieverolactones A-H, Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana".CHINESE JOURNAL OF CHEMISTRY 42.10(2024):1084-1092.

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