Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis

doi:10.1002/cbdv.202400980

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	Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis
	Jia, Jian-Ke; Yang, Jun; Yang, Xing-Zhi; Luo, Ji-Feng; Duan, Xiao-Yan; Yang, Ying-Li; Wan, Jin-Fu; Wang, Yue-Hu
	2024
发表期刊	CHEMISTRY & BIODIVERSITY
ISSN	1612-1872
卷号	21 期号:7 页码:-
摘要	Three new polyhydroxylated spirostanol steroidal saponins, dulongenosides B-D (2-4), along with 14 known compounds, dulongenoside A (1), padelaoside B (5), parisyunnanoside G (6), polyphyllin D (7), ophiopogonin C ' (8), formosanin C (9), dioscin (10), paris saponin VII (11), paris H (12), parisyunnanoside I (13), protodioscin (14), proprotogracillin (15), crustecdysone (16), and stigmasterol-3-O-beta-d-glucopyranoside (17), were isolated from the rhizomes of Paris dulongensis (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. The isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B by the MTS test. Compounds 7-12 and 14 showed cytotoxic activity, with IC50 values ranging from 0.20 to 4.35 mu M. Proprotogracillin selectively inhibited A549 (IC50=0.58 mu M) and A549/Taxol (IC50=0.74 mu M) cells, with no significant cytotoxic activity against HL-60, SW480, MDA-MB-231, or BEAS-2B cells, with IC50 values greater than 40 mu M.
DOI	10.1002/cbdv.202400980
WOS记录号	WOS:001254036100001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76341
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Jia, Jian-Ke,Yang, Jun,Yang, Xing-Zhi,et al. Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis[J]. CHEMISTRY & BIODIVERSITY,2024,21(7):-.
APA	Jia, Jian-Ke.,Yang, Jun.,Yang, Xing-Zhi.,Luo, Ji-Feng.,Duan, Xiao-Yan.,...&Wang, Yue-Hu.(2024).Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis.CHEMISTRY & BIODIVERSITY,21(7),-.
MLA	Jia, Jian-Ke,et al."Polyhydroxylated Spirostanol Saponins from the Rhizomes of Paris dulongensis".CHEMISTRY & BIODIVERSITY 21.7(2024):-.

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