1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity

doi:10.1016/j.phytochem.2024.114093

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	1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity
	Wei, Yinling; Li, Sheng; Wen, Hongyan; Dong, Jing; Liang, Zhenzhen; Li, Xiaoyu; Zhang, Yu
	2024
发表期刊	PHYTOCHEMISTRY
ISSN	0031-9422
卷号	222 页码:114093
摘要	Nine 3-arylisoquinoline alkaloids including five undescribed ones, hypectumines A -E ( 1 - 5 ), were isolated from the whole herb of Hypecoum erectum L. with the guidance of 1 H-NMR. Their structures were established by a combination of 1D, 2D NMR, and HRESIMS spectrometry. Among them, hypectumines A and B possessed rare urea moieties while hypectumines C and D were characterized by 3-(methylamino)propanoic acid scaffolds. Biological assay demonstrated that alkaloids hypectumine B and 2,3-dimethoxy- N -formylcorydamine had antiinflammatory effects by inhibiting NO production on LPS-induced RAW264.7 cells with IC 50 values of 24.4 and 44.2 mu M, respectively. Furthermore, hypectumine B could reduce the expression of pro -inflammatory cytokines TNF- alpha and IL -6, suggesting it might be a potential candidate for treating inflammatory disease.
DOI	10.1016/j.phytochem.2024.114093
WOS记录号	WOS:001229887900001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kib.ac.cn/handle/151853/76315
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wei, Yinling,Li, Sheng,Wen, Hongyan,et al. 1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity[J]. PHYTOCHEMISTRY,2024,222:114093.
APA	Wei, Yinling.,Li, Sheng.,Wen, Hongyan.,Dong, Jing.,Liang, Zhenzhen.,...&Zhang, Yu.(2024).1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity.PHYTOCHEMISTRY,222,114093.
MLA	Wei, Yinling,et al."1H NMR guided isolation of 3-arylisoquinoline alkaloids from Hypecoum erectum L. and their anti-inflammation activity".PHYTOCHEMISTRY 222(2024):114093.

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